A filter design approach to maximize ampacity of cables in nonsinusoidal power systems

This paper presents an optimal design of the C-type passive filters for the effective utilization of the power cables under nonsinusoidal conditions based on maximization of the harmonic derating factor (HDF) of a power cable, where maintaining the load true power factor at an acceptable range is desired. According to IEEE Standard 519, the total harmonic distortions of the voltage and current measured at the point of common coupling are taken into account as main constraints of the proposed approach. The presented numerical results show that the proposed approach provides higher current carrying capacity, or ampacity of the cables under nonsinusoidal conditions when compared to the traditional approaches based on minimization of the current total harmonic distortion and maximization of the true load power factor. A numerical case study is presented to demonstrate the proposed approach

Exact Results of the 1D 1/r21/r^2 Supersymmetric t-J Model without Translational Invariance

In this work, we continue the study of the supersymmetric t-J model with 1/r^2 hopping and exchange without translational invariance. A set of Jastrow wavefunctions are obtained for the system, with eigenenergies explicitly calculated. The ground state of the t-J model is included in this set of wavefunctions. The spectrum of this t-J model consists of equal-distant energy levels which are highly degenerate.Comment: 14 pages, Late

Antioxidant activity of phenolic extracts from olive mill wastewater and their influence on virgin olive oil stability

Fresh olive oil mill wastewaters (OMW) were collected in northern Morocco from industrial mills operating with three extraction systems (dual [C2] and triple phase [C3] centrifugation decanters and super-pressure system [SP]) during the 2017 growing season. Physicochemical and microbiological characteristics of these effluents were examined. OMW phenolic extracts were prepared and their antioxidant activities were evaluated. Moreover, the improvement of virgin olive oil stability by the addition of OMW phenolic extracts (at 100, 300 and 500 ppm) was investigated. Results from the present work confirmed the pollutant load of these effluents characterized by an acidic pH, strong organic content, and considerable amounts of mineral matter. Concerning the microbiological counts, yeasts and molds were the most abundant. Among extraction system, C2 displayed OMW with the high levels for all measured parameters, except for total phenols that were more abundant in C3. Findings from DPPH and FRAP tests showed a good antiradical potential and an important reducing power capacity and were both concentration-dependent. For the two tests, antioxidant activity of OMW phenolic extracts from C2 was the most important. The addition of phenolic extracts to virgin olive oil, stocked at 60°C, resulted in lower values of PV, K232 and K270 compared to the control, indicating a good protective effect against oil oxidation. The great antioxidant effect of OMW extracts was at 500 ppm, similar to that of ascorbic acid

Luminal leptin inhibits L-glutamine transport in rat small intestine: involvement of ASCT2 and B0AT1.

L-glutamine is the primary metabolic fuel for enterocytes. Glutamine from the diet is transported into the absorptive cells by two sodium-dependent neutral amino acid transporters present at the apical membrane: ASCT2/SLC1A5 and B(0)AT1/SLC6A19. We have demonstrated that leptin is secreted into the stomach lumen after a meal and modulates the transport of sugars after binding to its receptors located at the brush border of the enterocytes. The present study was designed to address the effect of luminal leptin on Na(+)-dependent glutamine (Gln) transport in rat intestine and identify the transporters involved. We found that 0.2 nM leptin inhibited uptake of Gln and phenylalanine (Phe) (substrate of B(0)AT1) using everted intestinal rings. In Ussing chambers, 10 mM Gln absorption followed as Na(+)-induced short-circuit current was inhibited by leptin in a dose-dependent manner (maximum inhibition at 10 nM; I(C50) = approximately 0.1 nM). Phe absorption was also decreased by leptin. Western blot analysis after 3-min incubation of the intestinal loops with 10 mM Gln, showed marked increase of ASCT2 and B(0)AT1 protein in the brush-border membrane that was reduced by rapid preincubation of the intestinal lumen with 1 nM leptin. Similarly, the increase in ASCT2 and B(0)AT1 gene expression induced by 60-min incubation of the intestine with 10 mM Gln was strongly reduced after a short preincubation period with leptin. Altogether these data demonstrate that, in rat, leptin controls the active Gln entry through reduction of both B(0)AT1 and ASCT2 proteins traffic to the apical plasma membrane and modulation of their gene expression

Harnessing bacterial power in microscale actuation

This paper presents a systematic analysis of the motion of microscale structures actuated by flagellated bacteria. We perform the study both experimentally and theoretically. We use a blotting procedure to attach flagellated bacteria to a buoyancy-neutral plate called a microbarge. The motion of the plate depends on the distribution of the cells on the plate and the stimuli from the environment. We construct a stochastic mathematical model for the system, based on the assumption that the behavior of each bacterium is random and independent of that of its neighbors. The main finding of the paper is that the motion of the barge plus bacteria system is a function of a very small set of parameters. This reduced-dimensional model can be easily estimated using experimental data. We show that the simulation results obtained from the model show an excellent match with the experimentally-observed motion of the barge

Global social challenges for development studies in the Crisis in the Anthropocene

This panel discussion session explores some of the central dimensions of the Crisis in the Anthropocene that constitute global social challenges in the context of development studies. The conference theme highlighted the profound human impact on our blue-green-brown planet, that is already breaching planetary boundaries and pushing us beyond the roughly 1.5°C tipping point. This threatens liveability and sustainability in many localities and regions and may well rapidly be ‘off the scale’ of imaginability and survivability. Inevitably, as mounting empirical evidence and increasingly clear projections by the IPCC and other authoritative bodies show, these impacts are unevenly spread, both socially and spatially, both now and over the coming decades. The urgency of appropriate action is undeniable and we already know many dimensions of the required adaptations and transformations. Yet progress mostly remains too slow. These challenges are vital to the development studies community – heterogenous as it is – with our concerns for tackling poverty, inequality, deprivation and environmental degradation globally and locally. Hence this symposium asks what the crisis means for development theory, policy and practice and what development studies can and should be contributing to – and, indeed, whether it is capable of – addressing some key dimensions that warrant greater attention

Positive Regulatory Control Loop between Gut Leptin and Intestinal GLUT2/GLUT5 Transporters Links to Hepatic Metabolic Functions in Rodents

International audienceBACKGROUND AND AIMS: The small intestine is the major site of absorption of dietary sugars. The rate at which they enter and exit the intestine has a major effect on blood glucose homeostasis. In this study, we determine the effects of luminal leptin on activity/expression of GLUT2 and GLUT5 transporters in response to sugars intake and analyse their physiological consequences. METHODOLOGY: Wistar rats, wild type and AMPKalpha(2) (-/-) mice were used. In vitro and in vivo isolated jejunal loops were used to quantify transport of fructose and galactose in the absence and the presence of leptin. The effects of fructose and galactose on gastric leptin release were determined. The effects of leptin given orally without or with fructose were determined on the expression of GLUT2/5, on some gluconeogenesis and lipogenic enzymes in the intestine and the liver. PRINCIPAL FINDINGS: First, in vitro luminal leptin activating its receptors coupled to PKCbetaII and AMPKalpha, increased insertion of GLUT2/5 into the brush-border membrane leading to enhanced galactose and fructose transport. Second in vivo, oral fructose but not galactose induced in mice a rapid and potent release of gastric leptin in gastric juice without significant changes in plasma leptin levels. Moreover, leptin given orally at a dose reproducing comparable levels to those induced by fructose, stimulated GLUT5-fructose transport, and potentiated fructose-induced: i) increase in blood glucose and mRNA levels of key gluconeogenesis enzymes; ii) increase in blood triglycerides and reduction of mRNA levels of intestinal and hepatic Fasting-induced adipocyte factor (Fiaf) and iii) increase in SREBP-1c, ACC-1, FAS mRNA levels and dephosphorylation/activation of ACC-1 in liver. CONCLUSION/SIGNIFICANCE: These data identify for the first time a positive regulatory control loop between gut leptin and fructose in which fructose triggers release of gastric leptin which, in turn, up-regulates GLUT5 and concurrently modulates metabolic functions in the liver. This loop appears to be a new mechanism (possibly pathogenic) by which fructose consumption rapidly becomes highly lipogenic and deleterious

Formation and optogenetic control of engineered 3D skeletal muscle bioactuators

Densely arrayed skeletal myotubes are activated individually and as a group using precise optical stimulation with high spatiotemporal resolution. Skeletal muscle myoblasts are genetically encoded to express a light-activated cation channel, Channelrhodopsin-2, which allows for spatiotemporal coordination of a multitude of skeletal myotubes that contract in response to pulsed blue light. Furthermore, ensembles of mature, functional 3D muscle microtissues have been formed from the optogenetically encoded myoblasts using a high-throughput device. The device, called “skeletal muscle on a chip”, not only provides the myoblasts with controlled stress and constraints necessary for muscle alignment, fusion and maturation, but also facilitates the measurement of forces and characterization of the muscle tissue. We measured the specific static and dynamic stresses generated by the microtissues and characterized the morphology and alignment of the myotubes within the constructs. The device allows testing of the effect of a wide range of parameters (cell source, matrix composition, microtissue geometry, auxotonic load, growth factors and exercise) on the maturation, structure and function of the engineered muscle tissues in a combinatorial manner. Our studies integrate tools from optogenetics and microelectromechanical systems (MEMS) technology with skeletal muscle tissue engineering to open up opportunities to generate soft robots actuated by a multitude of spatiotemporally coordinated 3D skeletal muscle microtissues.National Science Foundation (U.S.) (Science and Technology Center—Emergent Behaviors of Integrated Cellular Systems (EBICS) grant No. CBET-0939511)National Institutes of Health (U.S.) (EB00262)National Science Foundation (U.S.) (GM74048)National Science Foundation (U.S.) (HL90747)National Institute for Biomedical Imaging and Bioengineering (U.S.) (RESBIO, Integrapted Technologies for Polymeric Biomaterial)University of Pennsylvania. Center for Engineering Cells and RegenerationSingapore-MIT Alliance for Research and Technolog

Leptin regulates sugar and amino acids transport in the human intestinal cell line Caco-2

Aim: Studies in rodents have shown that leptin controls sugars and glutamine entry in the enterocytes by regulating membrane transporters. Here, we have examined the effect of leptin on sugar and amino acids absorption in the human model of intestinal cells Caco-2 and investigated the transporters involved. Methods: Substrate uptake experiments were performed in Caco-2 cells, grown on plates, in the presence and the absence of leptin and the expression of the different transporters in brush border membrane vesicles was analysed by Western blot. Results: Leptin inhibited 0.1 mM α-methyl-D-glucoside uptake after 5 or 30 min treatment, and decreased SGLT1 protein abundance in the apical membrane. Uptake of 20 µM glutamine and 0.1 mM phenylalanine was also inhibited by leptin, indicating sensitivity to the hormone of the Na+-dependent neutral amino acid transporters ASCT2 and B0AT1. This inhibition was accompanied by a reduction of the transporters expression at the brush-border membrane. Leptin also inhibited 1 mM proline and β-alanine uptake in Na+ medium at pH 6, conditions for optimal activity of the H+-dependent neutral amino acid transporter PAT1. In this case, abundance of PAT1 in the brush-border membrane after leptin treatment was not modified. Interestingly, leptin inhibitory effect on β-alanine uptake was reversed by the PKA inhibitor H-89 suggesting involvement of PKA pathway in leptin´s regulation of PAT1 activity. Conclusion: These data show in human intestinal cells that leptin can rapidly control the activity of physiologically relevant transporters for rich-energy molecules, i.e D-glucose (SGLT1) and amino acids (ASCT2, B0AT1 and PAT1)