Features of construction of the training process skiers aged 17-18 years to compete in different styles of skiing

The work is devoted to the improvement of precompetitive preparation of skiers, taking into account the need to participate in competitions of different styles of skiing. The experiment included 20 athletes aged 17-18 years. Isolated model characteristics of athletes who successfully perform classic and skating style of movement. The range of indicators of physical fitness of athletes, which is the norm for this level of qualification. The technique of constructing precompetitive preparation of athletes on the basis of a combination of style of movement. It was established experimentally that the combination of training sessions during the day improves athletic performance in racing classic and skating style. In this case, primary and secondary occupation to carry out a different style of skiing with a change of their rotation on the next day

Targeting of Rad51-dependent homologous recombination: implications for the radiation sensitivity of human lung cancer cell lines

The aim of the present work was to study the role of Rad51-dependent homologous recombination in the radiation response of non-small-cell lung cancer (NSCLC) cell lines. A dose- and time-dependent increase in the formation of Rad51 and γ-H2AX foci with a maximum at about 4 and 1 h after irradiation, followed by a decrease, has been found. The relative fraction of cells with persisting Rad51 foci was 20–30% in radioresistant and 60–80% in radiosensitive cell lines. In comparison, a higher fraction of residual Dsb was evident in cell lines with nonfunctional p53. Transfection with As-Rad51 significantly downregulates radiation-induced formation of Rad51 foci and increases apoptosis, but did not influence the rejoining of DNA double-strand breaks. Interestingly, wortmannin, a well-known inhibitor of nonhomologous end-joining, also inhibits Rad51 foci formation. In general, there was no correlation between the clonogenic survival at 2 Gy and the percentage of initial Rad51 or γ-H2AX foci after ionising radiation (IR). The most reliable predictive factor for radiosensitivity of NSCLC cell lines was the relative fraction of Rad51 foci remaining at 24 h after IR. Although most of the Rad51 foci are co-localised with γ-H2AX foci, no correlation of the relative fraction of persisting γ-H2AX foci and SF2 is evident

Особливості кровопостачання вентрального відділу хребта при різних за тривалістю динамічних фізичних навантаженнях

A change blood supply of bodies of vertebrae and intervertebral disks in the conditions of the dynamic loads is studied. Work is executed on 90 white rats-males which hurried with the electronic meter of length at run during 20 and 90 days. It is shown, that protracted running in the in the decreasing of the level of blood supply of subchondral part of vertebrae bodies, boundary with disks. Changes are accompanied activating of processes of resorption of bone structures of vertebrae, growing in the disks of vessels and violation of their structural integrity. The moderate dynamic loadings, opposite, activated blood supply of vertebrae at the maintainance of structure of disksИзучено изменение уровня кровоснабжения тел позвонков и межпозвонковых дисков в условиях динамических нагрузок. Работа выполнена на 90 белых крысах-самцах, которые бежали с электронным счетчиком длины бега в течение 20-ти и 90-та дней. Показано, что длительный бег способствует снижению уровня кровоснабжения отделов тел позвонков, пограничных с дисками. Изменения сопровождаются активацией процессов резорбции костных структур позвонков, врастанием в диски сосудов и нарушением их структурной целостности. Умеренные динамические нагрузки, напротив, активировали кровоснабжение позвонков при сохранении структуры дисковВивчена зміна рівня кровопостачання тіл хребців і міжхребцевих дисків в умовах динамічних навантажень. Роботу виконано на 90 білих щурах-самцях, які бігли в лінійному тредбані з електронним лічильником бігу протягом 20-ти і 90-та днів. Показано, що тривалий біг сприяє зниженню рівня кровопостачання відділів тіл хребців, прикордонних з дисками. Зміни супроводжуються активацією процесів резорбції кісткових структур хребців, вростанню в диски судин і порушенням їх структурної цілісності. Помірні динамічні навантаження, навпаки, активували кровопостачання хребців при збереженні структури дисків

Autologous anti-SOX2 antibody responses reflect intensity but not frequency of antigen expression in small cell lung cancer

Cataloged from PDF version of article.Background: Anti-SOX2 antibody responses are observed in about 10 to 20% of small cell lung cancer (SCLC) patients. The aim of this study was to determine whether such responses reflect a particular pattern of SOX2 protein expression in the tumor and whether this pattern associates with clinical outcome. Methods. Paraffin embedded tumor tissues, obtained from SCLC patients who had no evidence of paraneoplastic autoimmune degeneration, were evaluated for SOX2 expression by immunohistochemistry for both intensity and extent of staining. Sera from the same patients were tested for autologous antibodies against recombinant SOX2 by enzyme-linked immunosorbent assay (ELISA). Correlates between overall survival and various clinical parameters including SOX2 staining and serology were determined. Results: SOX2 protein expression was observed in tumor tissue in 89% of patients. Seventeen patients (29%) were seropositive for SOX2 antibodies and, in contrast to SOX2 staining, the presence of antibody correlated with limited disease stage (p = 0.05). SOX2 seropositivity showed a significant association with the intensity of SOX2 staining in the tumor (p = 0.02) but not with the frequency of SOX2 expressing cells. Conclusion: Anti-SOX2 antibodies associate with better prognosis (limited stage disease) while SOX2 protein expression does not; similar to reports from some earlier studies. Our data provides an explanation for this seemingly contrasting data for the first time as SOX2 antibodies can be observed in patients whose tumors contain relatively few but strongly staining cells, thus supporting the possible presence of active immune-surveillance and immune-editing targeting SOX2 protein in this tumor type. © 2014 Atakan et al.; licensee BioMed Central Ltd

On stability of the three-dimensional fixed point in a model with three coupling constants from the ϵ\epsilon expansion: Three-loop results

The structure of the renormalization-group flows in a model with three quartic coupling constants is studied within the $\epsilon$-expansion method up to three-loop order. Twofold degeneracy of the eigenvalue exponents for the three-dimensionally stable fixed point is observed and the possibility for powers in $\sqrt{\epsilon}$ to appear in the series is investigated. Reliability and effectiveness of the $\epsilon$-expansion method for the given model is discussed.Comment: 14 pages, LaTeX, no figures. To be published in Phys. Rev. B, V.57 (1998

Flow Equations for U_k and Z_k

By considering the gradient expansion for the wilsonian effective action S_k of a single component scalar field theory truncated to the first two terms, the potential U_k and the kinetic term Z_k, I show that the recent claim that different expansion of the fluctuation determinant give rise to different renormalization group equations for Z_k is incorrect. The correct procedure to derive this equation is presented and the set of coupled differential equations for U_k and Z_k is definitely established.Comment: 5 page

Autologous anti-SOX2 antibody responses reflect intensity but not frequency of antigen expression in small cell lung cancer

Background: Anti-SOX2 antibody responses are observed in about 10 to 20% of small cell lung cancer (SCLC) patients. The aim of this study was to determine whether such responses reflect a particular pattern of SOX2 protein expression in the tumor and whether this pattern associates with clinical outcome. Methods. Paraffin embedded tumor tissues, obtained from SCLC patients who had no evidence of paraneoplastic autoimmune degeneration, were evaluated for SOX2 expression by immunohistochemistry for both intensity and extent of staining. Sera from the same patients were tested for autologous antibodies against recombinant SOX2 by enzyme-linked immunosorbent assay (ELISA). Correlates between overall survival and various clinical parameters including SOX2 staining and serology were determined. Results: SOX2 protein expression was observed in tumor tissue in 89% of patients. Seventeen patients (29%) were seropositive for SOX2 antibodies and, in contrast to SOX2 staining, the presence of antibody correlated with limited disease stage (p = 0.05). SOX2 seropositivity showed a significant association with the intensity of SOX2 staining in the tumor (p = 0.02) but not with the frequency of SOX2 expressing cells. Conclusion: Anti-SOX2 antibodies associate with better prognosis (limited stage disease) while SOX2 protein expression does not; similar to reports from some earlier studies. Our data provides an explanation for this seemingly contrasting data for the first time as SOX2 antibodies can be observed in patients whose tumors contain relatively few but strongly staining cells, thus supporting the possible presence of active immune-surveillance and immune-editing targeting SOX2 protein in this tumor type. © 2014 Atakan et al.; licensee BioMed Central Ltd

Critical behavior of three-dimensional magnets with complicated ordering from three-loop renormalization-group expansions

The critical behavior of a model describing phase transitions in 3D antiferromagnets with 2N-component real order parameters is studied within the renormalization-group (RG) approach. The RG functions are calculated in the three-loop order and resummed by the generalized Pade-Borel procedure preserving the specific symmetry properties of the model. An anisotropic stable fixed point is found to exist in the RG flow diagram for N > 1 and lies near the Bose fixed point; corresponding critical exponents are close to those of the XY model. The accuracy of the results obtained is discussed and estimated.Comment: 10 pages, LaTeX, revised version published in Phys. Rev.

Економіка підприємства: методичні вказівки до проведення лабораторних занять

Методичні вказівки містять загальні вказівки до виконання лабораторних робіт, поради щодо визначення показників виробничо-господарської діяльності підприємства, вихідні дані для лабораторних робіт, список рекомендованої літератури