11 research outputs found
Squamous cell carcinoma of the maxillary sinus: A Tata Memorial Hospital experience
Background: The optimal treatment of maxillary sinus carcinoma remains
to be defined and there is a paucity of Indian studies on the subject.
Aims: To present experience of management of squamous cell carcinoma
of the maxillary sinus treated with curative intent at a single
institution. Settings and Design:Retrospective study of patients with
squamous cell carcinoma of the maxillary sinus who presented between
1994 to 1999. Materials and Methods:The records of 73 patients with
squamous cell carcinoma of the maxillary sinus were analyzed. Sixty-two
patients were evaluable. Forty patients (65%) were treated with surgery
followed by postoperative radiotherapy, five patients (8%) were treated
with radiotherapy alone, five patients (8%) were treated with surgery
alone; 12 patients (19%) received chemotherapy. Statistical analysis
used: Statistical analysis was done using Kaplan-Meier method.
Results: The majority of patients presented with locally advanced
disease (52, 84%); nodal involvement was observed in five patients
(8%). The most common site of recurrence was at the primary site, which
was observed in 28 patients (45%) and regional failures occurred in 10
(16%). The 3 and 5-year overall survival was 38% and 35% and the
disease free survival was 29% and 26% respectively. The 5-year overall
survival after surgery and postoperative radiotherapy was 42%.
Conclusions:The majority of patients present with advanced disease
resulting in poor outcomes to conventional treatment modalities.
Locoregional tumor progression remains a significant pattern of
failure. New approaches such as neoadjuvant or concomitant
chemoradiotherapy with aggressive surgery need to be considered and
evaluated in prospective studies
Case Report - Hemangioma of base of tongue
Although vascular malformations of the tongue comprise a significant
portion of head and neck angiodysplastic lesions, hemangioma of base of
tongue is rare. We report a case of hemangioma of base of tongue
extending to the supraglottis, which necessitated an extended
supraglottic laryngectomy. Patient had an uneventful recovery and at
three year, follow-up has a normal speech and no difficulty in
swallowing or aspiration. More importantly, there was no recurrence of
hemangioma or bleeding. Although hemangiomas may be treated by various
conservative methods, occasionally patient may require surgical
excision as in the present case due to the repeated bleeding episode
and difficult access. A high index of suspicion and radiological
investigations should be performed if the clinical presentation is
atypical for malignancy, as in our case
Desmoplastic small round cell tumor of the pancreas: An unusual primary site for an uncommon tumor
Pancreas is a rare location for desmoplastic small round cell tumor. The present case highlights the dilemma in diagnosis and ascertaining the site of tumor origin. Morphologic and immunohistochemical features were complemented with the molecular markers and tumor origin which was initially nebulous was subsequently confirmed on exploratory laparotomy