軟組織による外耳道閉鎖症例での軟骨伝導

A hearing aid using cartilage conduction (CC) has been proposed as an alternative to bone conduction (BC) hearing aids. The transducer developed for this application is lightweight, requires a much smaller fixation force than a BC hearing aid, and is more convenient to use. CC can be of great benefit to patients with fibrotic aural atresia. Fibrotic tissue connected to the ossicles provides an additional pathway (termed fibrotic tissue pathway) for sound to reach the cochlea by means of CC. To address the function of fibrotic tissue pathway, BC and CC thresholds were measured in six ears with fibrotic aural atresia. The relationship between the CC thresholds and the results of computed tomography was investigated. In the ears with the presence of a fibrotic tissue pathway, the CC thresholds were lower than the BC thresholds at 0.5 and 1.0 kHz. At 2.0 kHz, no significant difference was observed between the BC and CC thresholds. The current findings suggest that sound in the low to middle frequency range is transmitted more efficiently by CC via a fibrotic tissue pathway than BC. The development of hearing devices using CC can contribute to rehabilitation, particularly in patients with fibrotic aural atresia.博士（医学）・甲621号・平成26年3月17

Data mining tools for the Saccharomyces cerevisiae morphological database

For comprehensive understanding of precise morphological changes resulting from loss-of-function mutagenesis, a large collection of 1 899 247 cell images was assembled from 91 271 micrographs of 4782 budding yeast disruptants of non-lethal genes. All the cell images were processed computationally to measure ∼500 morphological parameters in individual mutants. We have recently made this morphological quantitative data available to the public through the Saccharomyces cerevisiae Morphological Database (SCMD). Inspecting the significance of morphological discrepancies between the wild type and the mutants is expected to provide clues to uncover genes that are relevant to the biological processes producing a particular morphology. To facilitate such intensive data mining, a suite of new software tools for visualizing parameter value distributions was developed to present mutants with significant changes in easily understandable forms. In addition, for a given group of mutants associated with a particular function, the system automatically identifies a combination of multiple morphological parameters that discriminates a mutant group from others significantly, thereby characterizing the function effectively. These data mining functions are available through the World Wide Web at

CCR7 Signals Are Essential for Cortex–Medulla Migration of Developing Thymocytes

Upon TCR-mediated positive selection, developing thymocytes relocate within the thymus from the cortex to the medulla for further differentiation and selection. However, it is unknown how this cortex–medulla migration of thymocytes is controlled and how it controls T cell development. Here we show that in mice deficient for CCR7 or its ligands mature single-positive thymocytes are arrested in the cortex and do not accumulate in the medulla. These mutant mice are defective in forming the medullary region of the thymus. Thymic export of T cells in these mice is compromised during the neonatal period but not in adulthood. Thymocytes in these mice show no defects in maturation, survival, and negative selection to ubiquitous antigens. TCR engagement of immature cortical thymocytes elevates the cell surface expression of CCR7. These results indicate that CCR7 signals are essential for the migration of positively selected thymocytes from the cortex to the medulla. CCR7-dependent cortex–medulla migration of thymocytes plays a crucial role in medulla formation and neonatal T cell export but is not essential for maturation, survival, negative selection, and adult export of thymocytes

ある精神障害者の社会参加への過程：作業適応の視点から当事者の手記を分析する

研究報告Original Articles　精神障害を持った人が健康感を持って社会に参加するためには何が必要なのか，統合失調症者の西純一氏（仮名）の手記「精神障害を乗り越えて 40 歳ピアヘルパーの誕生」を読み，Schultz & Schkade の「作業適応過程モデル」を参考に回復段階ごとの日常生活の作業経験を分析した．本研究はナラティブ分析による質的研究である．Schultz & Schkade は，人は環境との交流の中で，「出来るようになりたい」と願い環境に働きかけ（習熟願望），環境は人に「できるように」期待，要求する（習熟要請）と述べた．その結果，その環境との交流で，人は作業に従事して環境に挑戦し，役割を得ると指摘した．西氏の場合，症状の強い段階では彼の環境は制限され，心身の保護とセルフケアが生活の主要な作業であったが，回復に従って環境からの要請が生産的なものへと移り変わり，それに応えて社会的な作業を通して環境に働きかけることで西氏は社会参加を実現させた．作業療法においては，健康感を持って社会に参加するように援助するためには，最大限の適応反応を導くことができる環境を見極めることが必要であることが示唆された．　The purpose of this study is to investigate how a person with mental problems participates in society and does or does not live with a sense of health and well-being.　“The Birth of The 40-year-old Peer Helper Who Overcame a Mental Disorder” written by Mr. Junichi Nishi (pseudonym). A man with schizophrenia was studied using narrative analysis to understand his occupational experience in everyday life and in every recovery stage, using Schultz and Schkade’s occupational adaptation process model. Schultz and Schkade proposed that the person reaches out to the environment and has a desire for mastery in interactions with it (desire for mastery). In turn, the social environment expects or demands the person to master this skill (demand for mastery). As a result, Schultz and Schkade stressed that the person is challenging the environment while engaging in his or her occupation, gaining an occupational role.　In the case of Mr. Nishi, in the symptomatic stage of the disease, his occupational demand from the social environment was limited, and mental and physical protection and self-care was his major focus in everyday life. However, for the sake of recovery, his occupational demand from his social environment expanded to include productive tasks. Thus, he challenged the environment, and realized social participation by performing tasks related to social work.　In occupational therapy, in order to help the patient become an active participant in society, and gain a sense of health and well-being, it is necessary to determine the kind of environment that can lead to maximal adaptive responses

Central concentration of warm and dense molecular gas in a strongly lensed submillimeter galaxy at z=6

We report the detection of the CO(12-11) line emission toward G09-83808 (or H-ATLAS J090045.4+004125), a strongly-lensed submillimeter galaxy at $z = 6.02$, with Atacama Large Millimeter/submillimeter Array observations. Combining previously detected [O III]$\,88\:\mathrm{\mu m}$, [N II]$\,205\:\mathrm{\mu m}$, and dust continuum at 0.6$\:$mm and 1.5$\:$mm, we investigate the physical properties of the multi-phase interstellar medium in G09-83808. A source-plane reconstruction reveals that the region of the CO(12-11) emission is compact ($R_\mathrm{{e, CO}}=0.49^{+0.29}_{-0.19}\,\mathrm{kpc}$) and roughly coincides with that of the dust continuum. Non-local thermodynamic equilibrium radiative transfer modeling of CO spectral-line energy distribution reveals that most of the CO(12-11) emission comes from a warm (kinetic temperature of $T_{\mathrm{kin}}=320\pm170\:$K) and dense ($\log(n_{\mathrm{H2}}/\mathrm{cm^{-3}})=5.4\pm0.6$) gas, indicating that the warm and dense molecular gas is concentrated in the central 0.5-kpc region. The luminosity ratio in G09-83808 is estimated to be $L_\mathrm{{CO(12-11)}} / L_\mathrm{{CO(6-5)}}=1.1\pm0.2$. The high ratio is consistent with those in local active galactic nuclei (AGNs) and $6<z<7$ quasars, the fact of which implies that G09-83808 would be a good target to explore dust-obscured AGNs in the epoch of reionization. In the reconstructed [O III]$\,88\:\mathrm{\mu m}$ and [N II]$\,205\:\mathrm{\mu m}$ cubes, we also find that a monotonic velocity gradient is extending over the central starburst region by a factor of two and that star-forming sub-components exist. High-resolution observations of bright [C II]$\,158\:\mathrm{\mu m}$ line emissions will enable us to characterize the kinematics of a possible rotating disk and the nature of the sub-components.Comment: 13 pages, 11 figures, accepted for publication in PAS

Photometry and Polarimetry of 2010 XC15_{15}: Observational Confirmation of E-type Near-Earth Asteroid Pair

Asteroid systems such as binaries and pairs are indicative of physical properties and dynamical histories of the Small Solar System Bodies. Although numerous observational and theoretical studies have been carried out, the formation mechanism of asteroid pairs is still unclear, especially for near-Earth asteroid (NEA) pairs. We conducted a series of optical photometric and polarimetric observations of a small NEA 2010 XC$_{15}$ in 2022 December to investigate its surface properties. The rotation period of 2010 XC$_{15}$ is possibly a few to several dozen hours and color indices of 2010 XC$_{15}$ are derived as $g-r=0.435\pm0.008$, $r-i=0.158\pm0.017$, and $r-z=0.186\pm0.009$ in the Pan-STARRS system. The linear polarization degrees of 2010 XC$_{15}$ are a few percent at the phase angle range of 58$^{\circ}$ to 114$^{\circ}$. We found that 2010 XC$_{15}$ is a rare E-type NEA on the basis of its photometric and polarimetric properties. Taking the similarity of not only physical properties but also dynamical integrals and the rarity of E-type NEAs into account, we suppose that 2010 XC$_{15}$ and 1998 WT$_{24}$ are of common origin (i.e., asteroid pair). These two NEAs are the sixth NEA pair and first E-type NEA pair ever confirmed, possibly formed by rotational fission. We conjecture that the parent body of 2010 XC$_{15}$ and 1998 WT$_{24}$ was transported from the main-belt through the $\nu_6$ resonance or Hungaria region.Comment: Resubmitted to AAS Journals. Any comments are welcom

Metastatic Renal Cell Carcinoma to the Left Sphenoid Sinus: A Case Report in Light of the Literature

A 79-year-old Japanese woman presented with a rare case of metastatic renal cell carcinoma to the left sphenoid sinus with left nasal bleeding. She had previously had right radical nephrectomy for renal cell carcinoma at the age of 64 years and brain and spinal cord infarction at 74 years. Endoscopic examination revealed no mass in the nasal cavity. CT and MRI revealed a tumor in the left sphenoid sinus. The size of the tumor increased gradually from 12 to 15 years after the radical nephrectomy. Complete resection with endoscopic surgery was performed without preoperative embolization. The tumor cells had clear cytoplasm and were arranged in a trabecular pattern lined by a layer of endothelial cells. These findings were identical to the pathological findings of the surgical specimen of the renal cell carcinoma from 15 years previous. A pathological diagnosis of metastatic renal cell carcinoma of clear cell type (grade 1) was made. PET-CT demonstrated no metastasis. The patient’s condition was successfully managed with excision of the tumor, and she remains well with no evidence of recurrence and metastasis 36 months after treatment. Metastatic renal cell carcinoma to the sphenoid sinus is rare, but it might be considered in the differential diagnosis of masses in the paranasal sinus even long after initial treatment of renal cancer