36 research outputs found
Human movement patterns of farmers and forest workers from the Thailand-Myanmar border
Background: Human travel patterns play an important role in infectious disease epidemiology and ecology. Movement into geographic spaces with high transmission can lead to increased risk of acquiring infections. Pathogens can also be distributed across the landscape via human travel. Most fine scale studies of human travel patterns have been done in urban settings in wealthy nations. Research into human travel patterns in rural areas of low- and middle-income nations are useful for understanding the human components of epidemiological systems for malaria or other diseases of the rural poor. The goal of this research was to assess the feasibility of using GPS loggers to empirically measure human travel patterns in this setting, as well as to quantify differing travel patterns by age, gender, and seasonality.
Methods: In this pilot study we recruited 50 rural villagers from along the Myanmar-Thailand border to carry GPS loggers for the duration of a year. The GPS loggers were programmed to take a time-stamped reading every 30 minutes. We calculated daily movement ranges and multi-day trips by age and gender. We incorporated remote sensing data to assess patterns of days and nights spent in forested or farm areas, also by age and gender.
Results: Our study showed that it is feasible to use GPS devices to measure travel patterns, though we had difficulty recruiting women and management of the project was relatively intensive. We found that older adults traveled farther distances than younger adults and adult males spent more nights in farms or forests.
Conclusion: The results of this study suggest that further work along these lines would be feasible in this region. Furthermore, the results from this study are useful for individual-based models of disease transmission and land use
Looking Back, Looking Forward: Progress and Prospect for Spatial Demography
In 2011 a specialist meeting on the “Future Directions in Spatial Demography” was
held in Santa Barbara, California (Matthews, Goodchild, & Janelle, 2012).1
This specialist meeting was the capstone to a multi-year National Institutes of Health training
grant that had supported workshops in advanced spatial analysis methods increasing used by population scientists.2
Early-career scholars who had participated in the
training workshops and senior demographers and geographers drawn from across
the United States participated in the specialist meeting.3
The application process to
attend the 2011 meeting, required that each of the forty-one attendees submit a statement that reviewed challenges and identifed new directions for spatial demography,
including gaps in current knowledge regarding innovations in geospatial data, spatial
statistical methods, and the integration of data and models to enhance the science of
spatial demography in population and health research. Reading again some of the ruminations of these scholars is an interesting exercise in its own right. The level
of optimism back in 2011 was high, and especially regarding anticipated changes
in computational capacity, leveraging big data (including volunteered geographic
information), developments in data systems (including new data high resolution data
products and online resources such as multi-scale map interfaces and dashboards),
and in methods such as time–space models, agent-based models, microsimulation,
and small-area estimation. There were also several challenges identifed including,
but not limited to, study designs, data integration, data validation, confdentiality,
non-representative data, historic data, defnitions of place, residential selection and
mobility as well as two overarching challenges related to the role and contribution of
spatial demographers in interdisciplinary population and health research, and many,
many comments on training issues. Substantively the attendees research focused
on all forms of interaction between people and place (and the reciprocal relations
between the people in social, built, and physical environment contexts) covering the
gamut of demographic processes from reproductive health to mortality, though with
perhaps an overrepresentation of researchers in areas related to population and environment research, racial and residential segregation, and migration.The R25 Training Grant was funded through the Eunice Kennedy Shriver National Institutes of Child
Health and Human Development (NICHD 5R-25 HD057002; Principal Investigator: Stephen A. Matthews).
Looking Back, Looking Forward: Progress and Prospect for Spatial Demography
In 2011 a specialist meeting on the “Future Directions in Spatial Demography” was
held in Santa Barbara, California (Matthews, Goodchild, & Janelle, 2012).1
This specialist meeting was the capstone to a multi-year National Institutes of Health training
grant that had supported workshops in advanced spatial analysis methods increasing used by population scientists.2
Early-career scholars who had participated in the
training workshops and senior demographers and geographers drawn from across
the United States participated in the specialist meeting.3
The application process to
attend the 2011 meeting, required that each of the forty-one attendees submit a statement that reviewed challenges and identifed new directions for spatial demography,
including gaps in current knowledge regarding innovations in geospatial data, spatial
statistical methods, and the integration of data and models to enhance the science of
spatial demography in population and health research. Reading again some of the ruminations of these scholars is an interesting exercise in its own right. The level
of optimism back in 2011 was high, and especially regarding anticipated changes
in computational capacity, leveraging big data (including volunteered geographic
information), developments in data systems (including new data high resolution data
products and online resources such as multi-scale map interfaces and dashboards),
and in methods such as time–space models, agent-based models, microsimulation,
and small-area estimation. There were also several challenges identifed including,
but not limited to, study designs, data integration, data validation, confdentiality,
non-representative data, historic data, defnitions of place, residential selection and
mobility as well as two overarching challenges related to the role and contribution of
spatial demographers in interdisciplinary population and health research, and many,
many comments on training issues. Substantively the attendees research focused
on all forms of interaction between people and place (and the reciprocal relations
between the people in social, built, and physical environment contexts) covering the
gamut of demographic processes from reproductive health to mortality, though with
perhaps an overrepresentation of researchers in areas related to population and environment research, racial and residential segregation, and migration.The R25 Training Grant was funded through the Eunice Kennedy Shriver National Institutes of Child
Health and Human Development (NICHD 5R-25 HD057002; Principal Investigator: Stephen A. Matthews).
Towards malaria elimination in Savannakhet, Lao PDR: mathematical modelling driven strategy design
Towards malaria elimination in Savannakhet, Lao PDR: mathematical modelling driven strategy design.
The assembly effect: the connectedness between populations is a double-edged sword for public health interventions.
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The assembly effect: the connectedness between populations is a double-edged sword for public health interventions.
BackgroundMany public health interventions lead to disruption or decrease of transmission, providing a beneficial effect for people in the population regardless of whether or not they individually participate in the intervention. This protective benefit has been referred to as a herd or community effect and is dependent on sufficient population participation. In practice, public health interventions are implemented at different spatial scales (i.e., at the village, district, or provincial level). Populations, however defined (i.e., neighbourhoods, villages, districts) are frequently connected to other populations through human movement or travel, and this connectedness can influence potential herd effects.MethodsThe impact of a public health intervention (mass drug administration for malaria) was modelled, for different levels of connectedness between populations that have similar disease epidemiology (e.g., two nearby villages which have similar baseline malaria incidences and similar malaria intervention measures), or between populations of varying disease epidemiology (e.g., two nearby villages which have different baseline malaria incidences and/or malaria intervention measures).ResultsThe overall impact of the interventions deployed could be influenced either positively (adding value to the intervention) or negatively (reducing the impact of the intervention) by how much the intervention units are connected with each other (e.g., how frequent people go to the other village or town) and how different the disease intensity between them are. This phenomenon is termed the "assembly effect", and it is a meta-population version of the more commonly understood "herd effect".ConclusionsThe connectedness of intervention units or populations is an important factor to be considered to achieve success in public health interventions that could provide herd effects. Appreciating the assembly effect can improve the cost-effective strategies for global disease elimination projects
Recommended from our members
The assembly effect: the connectedness between populations is a double-edged sword for public health interventions.
BackgroundMany public health interventions lead to disruption or decrease of transmission, providing a beneficial effect for people in the population regardless of whether or not they individually participate in the intervention. This protective benefit has been referred to as a herd or community effect and is dependent on sufficient population participation. In practice, public health interventions are implemented at different spatial scales (i.e., at the village, district, or provincial level). Populations, however defined (i.e., neighbourhoods, villages, districts) are frequently connected to other populations through human movement or travel, and this connectedness can influence potential herd effects.MethodsThe impact of a public health intervention (mass drug administration for malaria) was modelled, for different levels of connectedness between populations that have similar disease epidemiology (e.g., two nearby villages which have similar baseline malaria incidences and similar malaria intervention measures), or between populations of varying disease epidemiology (e.g., two nearby villages which have different baseline malaria incidences and/or malaria intervention measures).ResultsThe overall impact of the interventions deployed could be influenced either positively (adding value to the intervention) or negatively (reducing the impact of the intervention) by how much the intervention units are connected with each other (e.g., how frequent people go to the other village or town) and how different the disease intensity between them are. This phenomenon is termed the "assembly effect", and it is a meta-population version of the more commonly understood "herd effect".ConclusionsThe connectedness of intervention units or populations is an important factor to be considered to achieve success in public health interventions that could provide herd effects. Appreciating the assembly effect can improve the cost-effective strategies for global disease elimination projects
Cost-effectiveness analysis of G6PD diagnostic test for Plasmodium vivax radical cure in Lao PDR: an economic modelling study
Background Plasmodium vivax (Pv) infections were 68% of the total malaria burden in Laos in 2019. The parasite causes frequent relapses, which can be prevented by primaquine (PMQ). Testing for glucose-6-phosphate-dehydrogenase (G6PD) deficiency is recommended before giving PMQ to avoid haemolysis. Because of the risk of haemolysis in G6PD intermediate deficiencies among females, Laos uses the PMQ 14-days regimen only in G6PD normal females. Among G6PD point-of-care tests, qualitative tests cannot differentiate between G6PD normal and intermediate females. Quantitative tests are required to differentiate between G6PD normal and intermediate deficiencies. However, the quantitative test lacks the cost-effectiveness evidence necessary for decision-making for large-scale adoption. This study examined the cost-effectiveness of quantitative G6PD test, with either supervised PMQ treatment or unsupervised PMQ treatment, against the usual unsupervised PMQ 8-weeks strategy. Supervised PMQ 8-weeks strategy without G6PD testing was also compared against the unsupervised PMQ 8-weeks strategy since the former had recently been adopted in malaria high burden villages that had village malaria volunteers. A budget impact analysis was conducted to understand the incremental cost and effect needed for a nationwide scale-up of the chosen strategy. Methods A decision tree model compared the cost-effectiveness of implementing four strategies at one health facility with an average of 14 Pv cases in one year. The strategies were unsupervised PMQ strategy, supervised PMQ strategy, G6PD test with unsupervised PMQ strategy, and G6PD test with supervised PMQ strategy. Disability Adjusted Life Years (DALYs) was the effect measure. Costs were calculated from a payer perspective, and sensitivity analyses were conducted. One Gross Domestic Product (GDP) per capita of Laos was set as the cost-effectiveness threshold. Budget impact analysis was conducted using the health facility wise Pv data in Laos in 2020. Findings Supervised PMQ strategy was extendedly dominated by G6PD test strategies. When compared against the unsupervised PMQ strategy, both G6PD test strategies were more costly but more effective. Their Incremental Cost-Effectiveness Ratios (ICER) were 96.72US for the G6PD test with supervised PMQ strategy. Both ICERs were lower than one GDP per capita in Laos. Following the sensitivity analysis, low adherence for PMQ 14 days made both G6PD test strategies less cost-effective. The lower the Pv case number reported in a health facility, the higher the ICER was. In the budget impact analysis, the expected budget need was only half a million US$ when the G6PD test rollout was discriminately done depending on the Pv case number reported at the health facilities. Indiscriminate roll out of G6PD test to all health facilities was most expensive with least effect impact