A Wearable Heating System with a Controllable e-Textile- Based Thermal Panel

Flexible textile heating systems present great advantage due to their ability to bend and hence could ensure uniform heating for irregular geometries. In cooler outer environment, the user requires his/her body to be kept warm for monitoring vital body functions within realistic thermal body balance constraints. In this chapter, heated vest with controllable e-textile-based thermal panel has been studied. Several e-textile-based thermal panels with different conductive yarns were produced using hot air welding technology under different manufacturing parameters. E-textile-based thermal panels were tested for their heating behaviors at varying direct current (DC) power levels. Based on the experimental results, the optimum e-textile-based thermal panel design was chosen considering its flexibility and uniform heating behavior. Moreover, a control algorithm with electrical circuit and electrical connection network was designed and assembled in an electronic control module. Finally, the electronic module consisting of power control and management system was integrated to attachable e-textile-based thermal panel in order to form a wearable heating vest

Persistent Left Superior Vena Cava and Partial Anomalous Pulmonary Venous Return in an Old Asymptomatic Female Patient

Persistent left superior vena cava is a rare congenital venous anomaly. It results from failure of closure of the left anterior cardinal vein during cardiac development. It is usually asymptomatic but can be associated with other congenital cardiac defects including atrial septal defects, ventricular septal defects, endocardial cushion defects, tetralogy of Fallot and rhythm disturbances. PLSVC should be considered in the presence of a dilated coronary sinus on transthoracic echocardiography. The diagnosis can be made when injection of contrast in left antecubital vein results in enhancement of the dilated coronary sinus before right atrium. MRI, CT-scan and catheterisation can be used to confirm the diagnosis

Analysis of DNA damage using the comet assay method in metastatic castration resistant prostate cancer patients receiving 177Lu-PSMA-617 radioligand therapy

Aim: To evaluate possible DNA damage in metastatic castration-resistant prostate cancer patients receiving 177Lu-PSMA-617 radioligand therapy using the comet assay method. Methods: Prospectively included patients were divided into four groups: a control group and three treatment groups receiving 2, 4, and 6 cycles, respectively. Agarose-coated comet assay slides were prepared using samples obtained from routine blood tests before treatment, and electrophoresis was performed to detect DNA damage. Descriptive statistics, normality tests, and multiple comparison tests were performed. Results: Forty-five patients with a mean age of 75.5, Gleason scores of 3+4, 4+3, 4+5, and 5+5, and ECOG performance scores of 0/1, 2, and 3 were included in the study. In a valid Comet assay analysis, a similar number of cells were examined in the four treatment groups without any statistical differences. Group analyses revealed statistically significant differences between DNA damage levels. Specifically, the number of stage 0 cells showed a significant difference between the 0-2 and 4-6 cycles groups, while the number of cells with moderate/high levels of damage showed similarities between the 4-6 cycles groups. Conclusions: This study demonstrates an increase in DNA damage in peripheral blood lymphocytes with cumulative doses in prostate cancer patients treated with 177Lu-PSMA. These findings contribute to the understanding of the relationship between DNA damage during the treatment process and treatment cycles. &nbsp

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

All ligands of the epidermal growth factor receptor (EGFR), which has important roles in development and disease, are released from the membrane by proteases. In several instances, ectodomain release is critical for activation of EGFR ligands, highlighting the importance of identifying EGFR ligand sheddases. Here, we uncovered the sheddases for six EGFR ligands using mouse embryonic cells lacking candidate-releasing enzymes (a disintegrin and metalloprotease [ADAM] 9, 10, 12, 15, 17, and 19). ADAM10 emerged as the main sheddase of EGF and betacellulin, and ADAM17 as the major convertase of epiregulin, transforming growth factor α, amphiregulin, and heparin-binding EGF-like growth factor in these cells. Analysis of adam9/12/15/17−/− knockout mice corroborated the essential role of adam17−/− in activating the EGFR in vivo. This comprehensive evaluation of EGFR ligand shedding in a defined experimental system demonstrates that ADAMs have critical roles in releasing all EGFR ligands tested here. Identification of EGFR ligand sheddases is a crucial step toward understanding the mechanism underlying ectodomain release, and has implications for designing novel inhibitors of EGFR-dependent tumors

Sustainable collection development towards greener future: Earthsavers

Nowadays, environmental awareness is more important not to damage the living environment. Sources of the Earth have been decreasing day by day due to many natural and human-induced reasons such as global warming, waste disposal, urbanization, deforestation, etc. Harm of the textile sector on the environment is high and it needs control and awareness. Raw material production, raw material selection, water usage amount, sustainability of processes, refining of wastes, recycle and reuse strategies of textile companies have a very significant effect on the environment. With this awareness, sustainable fashion is created because customer behaviors affect both design and production. In this view, all ingredients and processes turn to the most sustainable forms as much as possible. While being environmentally friendly, required performances of garments should be met to prepare the required end product. In this study, a sustainable collection whose name is Earthsavers is prepared by using recycled raw materials, natural dyestuffs, etc. Their physical and chemical performances are tested. Results of the collection are suitable for acceptance levels and it shows that a collection can be prepared with minimum harm to the environment with at least the same performances as conventional alternatives

Symphyseal Bone Cylinders Tapping With the Dental Implant Into Insufficiency Bone Situated Esthetic Area at One-Stage Surgery: A Case Report and the Description of the New Technique

WOS: 000296371000011PubMed: 20553126Periodontal defects and trauma at the anterior maxillary region can cause a severe alveolar ridge deficiency resulting in an unesthetic view. Ideal implant positioning can be compromised by inadequate alveolar bone in terms of height and width. Reconstruction of osseous defects with autogenous bone allows ideal implant positioning and creates a more natural soft and hard tissue profile, which influences esthetic crown anatomy at the anterior maxillary region. In this case report, an alveolar ridge defect due to periodontally compromised tooth extraction was filled with autogenous bone cylinder and dental implant at one-stage surgery. In the presented case, a new technique was described which included bone reconstruction of the defects at the anterior maxillary region and simultaneous placement of the dental implant

Quadricuspid Aortic Valve Visualized by Three-Dimensional Transthoracic Echocardiography

Quadricuspid aortic valve is a rare congenital anomaly that may cause aortic regurgitation. A 77-year-old male patient was referred to our clinic with complaints of stable angina pectoris. We report a case of a quadricuspid aortic valve diagnosed by 3-dimentional transthoracic echocardiography