Neutrophil-lymphocyte ratio in catatonia

There is growing evidence of subclinical inflammation in mental disorders. Objective: The aim of this study was to investigate frequency of symptoms of catatonia and the newly diagnosed subclinical inflammatory markers which are neutrophil/lymphocyte (NLR), platelet/lymphocyte (PLR), monocyte/lymphocyte (MLR) ratios in catatonia patients due to mental disorders. Methods: Patients who were admitted to psychiatry clinic with the diagnosis of catatonia according to DSM 5 in the last two years and equal number of control group were included in this retrospective study. Univariate analysis of covariance controlled for possible confounders was used to compare NLR, PLR, MLR ratios between patients and the control group. Results: A total of 34 catatonia patients and 34 healthy controls were included in the study. Patients’ mean age was 30.88 + 13.4. NLR value was significantly higher in the patient group than control group. There was no significant difference between the patients and control group according to PLR, MLR values. Discussion: The presence of subclinical inflammation in catatonic syndrome due to mental disorders should be considered. Subclinical inflammation that was observed in numerous mental disorders continues in catatonia due to mental disorders. Large-scale studies are needed to determine the role of inflammation in catatonia

Recent Traumatic Episode Protocol EMDR Applied Online for COVID-19-Related Symptoms of Turkish Health Care Workers Diagnosed with COVID-19-Related PTSD: A Pilot Study

Background:This study investigates the effect of the online Eye Movement Desensitization and Reprocessing Recent Traumatic Episode Protocol on posttraumatic stress disorder, anxiety, depression, and burnout symptoms in healthcare workers diagnosed with pandemic-related post-traumatic stress disorder

METABOLIC SYNDROME IN PATIENTS WITH SCHIZOAFFECTIVE DISORDER AND RELATIONSHIP WITH THE ANTIPSYCHOTICS

WOS: 000424878600022Introduction: Metabolic syndrome is highly prevalent in patients with schizophrenia. The use of atypical antipsychotics also increases the risk of metabolic syndrome. This study aimed to evaluate the association between schizoaffective disorder and risk of incident metabolic syndrome and the relationship with the drugs used. Materials and methods: This cross-sectional study included patients diagnosed with schizoaffective disorder. The study group consisted of 77 outpatients aged 18 to 65 years, prescribed any antipsychotic medication between September 2013 and August 2014. Metabolic syndrome was defined using the criteria of the National Cholesterol Education Program - Adult Treatment Protocol and the National Cholesterol Education Program - Adapted Adult Treatment Protocol. Results: Metabolic syndrome was found in 33.8% according to National Cholesterol Education Program - Adult Treatment Protocol diagnostic criteria, 36.4% according to National Cholesterol Education Program - Adapted Adult Treatment Protocol diagnostic criteria of the patients. When we grouped patients treated with typical antipsychotic, atypical antipsychotics and typical & atypical antipsychotics in combination, there was no significant difference for prevalence of metabolic syndrome among any groups. Metabolic syndrome prevalence was significantly higher in study subjects using antidepressants in combination with antipsychotics. Conclusions: The results suggest that metabolic syndrome risk is common among patients with schizoaffective disorder. Our data shows that systemic inflammation plays a key role in both schizoaffective disorder and metabolic syndrome so chronic comorbid disorders should be treated concurrently and all risk factors like that weight loss, regular physical activity, smoking cessation should be eliminated by modifying life style

Identified predictors and levels of burnout among staff workers in a refugee camp of first immigrant group: A cross-sectional study

Essential workers in a refugee camp are exposed to many stressors that influence their ability to perform their duties. This study aims to investigate the relationship between burnout and job satisfaction, depression, anxiety, and socio-demographic variables among staff workers in a refugee camp in Turkey. The Maslach Burnout Inventory, which assesses emotional exhaustion, depersonalization and personal accomplishment, Minnesota Satisfaction Questionnaire, Beck Depression Inventory, Beck Anxiety Inventory, and socio-demographic variable form was administered to 199 staff workers in refugee camps in Turkey. High-risk levels were found to be 40.2% in emotional exhaustion, which is considered the center of burnout. Female gender, working in the camp (>12 months), low extrinsic satisfaction, and high anxiety and depression levels predicted the emotional exhaustion. While low intrinsic satisfaction, high depression levels, and working in the camp (>12 months) were found to be predictors for depersonalization, low intrinsic satisfaction was determined to be a predictor for reduced personal accomplishment. It was determined that burnout was high among the personnel working in the refugee camps and the factors that played a role in its development were female gender, working in the camp (>12 months), low extrinsic satisfaction, high anxiety and depression levels, and low intrinsic satisfaction. It is recommended that these personnel be evaluated first, improving their working conditions, and providing psychosocial support. [Med-Science 2022; 11(1.000): 135-41

Effects of electroconvulsive therapy on nitrosative stress and oxidative DNA damage parameters in patients with a depressive episode

Background Few studies have investigated the relationship between electroconvulsive therapy (ECT) and markers of nitrosative stress and oxidative DNA damage. Objective The aim of this study is to examine changes in nitrosative stress and oxidative DNA damage in patients with a depressive episode treated with ECT. Methods The current study included 48 patients with a depressive episode treated with ECT and 30 healthy control participants. First, the serum nitrosative stress markers of nitric oxide (NO center dot), nitric oxide synthase (NOS), and peroxynitrite (ONOO-) and the oxidative DNA damage marker 8-hydroxy-2 '-deoxyguanosine (8-OHdG) were compared between the study and control groups. These parameters were also compared pre- and post-treatment for the study group. Results NO center dot, NOS, and ONOO- levels were significantly higher in patients with depressive disorder (DD) than in the control group. NO center dot and NOS levels significantly decreased in the ECT group after treatment while 8-OHdG levels significantly increased. Conclusions The study findings suggest that ECT may have reduced nitrosative stress levels while increasing oxidative DNA damage. More research is now needed to better understand the issue