Multifarious Transnational Engagements of Contemporary Diaspora Members: From Revolving-door Universalists to Multi-nationals and Site-Hopping Vagabonds

Drawing on recent studies of diaspora and its members’ transnational engagements, which treat the former as fuzzy-boundary, context-dependent groupings, and the latter as multi-faceted (rather than two-pronged) relationships, in this paper I explore the notion of diasporans’ polymorphous and multi-directional transnational commitments; identify different types of such involvements; and propose a preliminary list of macro- and micro-level circumstances contributing to multifarious transnationalism. In conclusion, I consider the implications of the notion of diaspora members’ multifarious transnational engagements for the study of (im)migrant transnationalism in general and suggest some interesting questions for future research on this phenomenon generated by this discussion

Long-term avelumab in advanced non-small-cell lung cancer: summaries and post hoc analyses from JAVELIN Solid Tumor.

Background: This study examined patients with advanced non-small-cell lung cancer who received long-term avelumab (anti-PD-L1) in a large phase Ib trial (JAVELIN Solid Tumor). Methods: Patients receiving >2 years of avelumab were reviewed and exploratory descriptive analyses were conducted. Results: Individuals with varying baseline characteristics who had received up to 6 years of avelumab were reviewed. Overall, 37/340 (10.9%) had received ≥2 years of treatment; in this subgroup, best response was complete response in 5.4%, partial response in 59.5% and stable disease in 29.7%; 51.4% had continued treatment beyond disease progression. Conclusions: In this study, 11% of patients with advanced non-small-cell lung cancer received ≥2 years of avelumab treatment and experienced prolonged response or continued clinical benefit. Clinical Trial Registration: NCT02395172 (ClinicalTrials.gov)