Inverse scattering problem for a hyperbolic system of first order equations on a semi-axis on a first approximation

In this paper for a hyperbolic system of five equations on the semi-axis, by joint consideration of three problems an inverse scattering problem on a first approximation was solved. The coefficients of the considered system are uniquely determined by the scattering operator on the semi-axis

Morphological Characteristics of Tumors of the Outer Ear

The article is devoted to the morphological picture of tumors of the outer ear. It was found that benign tumors predominate in the structure of tumors of the outer ear, which are most often found at the age of 30 years and are localized in the cartilaginous part of the external auditory canal and external ear. The main part consisted of keloids, glomus angiomas and lipomas. An important role in the diagnosis of tumors at the present stage is played by morphological methods, in particular, histological examination. It is noted that their timely use will contribute to effective prevention of benign tumors of the external ear

Leading Factors of Progression in Patients with Cardiac Amyloidosis

Aim. To describe prognostic meaning of cardiac and other principal clinical manifestations of systemic AL-amyloidosis in their interrelations.Material and methods. It has been made long-time survival analysis of 147 patients with systemic AL-amyloidosis. In the special investigation group (n=58) of AL (n=55) and ATTR (n=3) amyloidotic cardiopathy patients there were evaluated prognostically important structural and functional changes in myocardium with standard and impulse-wave tissue dopplerometric echocardiography in comparison with NTproBNP serum levels.Results. Even though significantly increased nowadays surviving of AL-amylodotic patients (Me=90 months) it has been found that as at previously time orthostatic hypotension and amyloid cardiopathy are being most severe initial syndromes (median 25 months), but after 1 year from diagnosis influence of these syndromes on surviving had decreased and most low surviving was more common in patients with CKD 3-5 (median 28 months). Influence of CKD 3-5 on surviving was associated predominantly with intracardial hemodynamics deterioration. Together with decreased systolic shortening strain rate (48,5%) decreased filtration rate (47,9%) was second of main factors contributing into NTproBNP increasing in effective multiple regression model (R=0,702, F(4,21)=5,095, p=0,005). NTproBNP level in less degree depended on renal clearance.Conclusion. Heart damage is one of the most prognostically unfavorable manifestations of systemic amyloidosis due to a sharp deterioration in the elastic properties of the myocardium, in the process of further development of amyloidosis, the leading factor in progression is the deterioration of the profile of cardiorenal interactions, the marker of which is the level of NTproBNP

The role of anatomical and topographic features of angioarchitectonics and nerve gliding for its recovery

In the modern concept of treatment of patients with injuries of peripheral nerves, the main thing is to understand the mechanism of its sliding and the peculiarities of blood supply. Studying the nerve topographic anatomy, we are convinced that the mobility of the nerve exists not only in relation to the tissues surrounding it, but also at the level of its inner bundles. In this article, we report on the different degree of nerve mobility depending on its location zone, and that the ulnar and median nerves have the highest degree of mobility at the level of the forearm distal third. To calculate the change in the glide of the nerves, a mathematical model was constructed to measure their mobility during flexion and extension in the elbow joint, allowing to personalize the flap plasty depending on the length of the autograph vascular pedicle. The anatomical and topographic features of the angioarchitectonics of the nerve at various levels were studied, the presence and variability of the location of the vascular pedicle of blood-supplied autografts were studied. The obtained knowledge is necessary for carrying out revascularization of the damaged nerve zone with various types of autografts with autonomous blood flow. Conclusions. Knowledge of the anatomical and topographic features of peripheral nerves, their blood supply and mobility is necessary for their recovery for various injuries

Coagulation Disorders in Infective Endocarditis: Role of Pathogens, Biomarkers, Antithrombotic Therapy (Systematic Review)

The issue of antithrombotic therapy in patients with infective endocarditis has been studied for over 75 years. During that time studying of pathogenesis of the disease and its embolic complications, lead to the introduction of the concept of “immunothrombosis”. That mechanism allows infective agents (mostly bacteria) to be cloaked from the immune system and to multiply freely, leading to growth of vegetation, thus resulting in higher chance of fragmentation. Small-scale experimental and clinical studies on the correction of hemostatic disorders in infective endocarditis, that were performed in 20th century, didn’t show any significant results, that could affect clinical practice. However, reinterpretation of available data on coagulative system will allow to have elements of hemostasis as an application point in treating infective endocarditis. The article will discuss latest insights on the role of hemostasis system in pathophysisology of infective endocarditis, its effects on the development of the embolic complications, perspectives for diagnostics and treatment

ВЛИЯНИЕ 1%-НОГО РАСТВОРА ЦИФЛУТРИНА НА РЕПРОДУКТИВНУЮ ФУНКЦИЮ БЕЛЫХ КРЫС

The influence of 1 % solution of cyfluthrin on reproductive function of rats is studied. The drug in a dose of 1/5 from LD50 during 10 weeks didn’t influence on fecundity, reproductive function and postnatal development of posterity.Изучено влияние препарата на основе цифлутрина на репродуктивную систему белых крыс. Препарат при нанесении на кожу животных в дозе 1/5 от ЛД50 в течение 10 недель не оказывает влияния на плодовитость, репродуктивную функцию и постнатальное развитие крысят

A Case Report of Differential Diagnosis of Causes of Severe Valvular Heart Disease (Takayasu's Arteritis, Infective Endocarditis and Myxomatous Degeneration) with the Key Role of Histological and PCR Examination

Aortic valve lesion is a common and may have diverse causes, from degenerative, congenital and infectious diseases to autoimmune conditions. We present a rare case of Takayasu arteritis and severe heart lesion due to the myxomatous degeneration of the aortic and mitral valves associated with development of infective endocarditis (IE) complicated by abscess, fistula, valve perforation and recurrent acute decompensated heart failure in a young female patient. A combined use of histopathological and PCR analyses of valve tissues was critically important for differential diagnosis of the valve lesions, as it made it possible to identify the true cause of the disease. The presence of Takayasu arteritis has played an indirect role by creating conditions for the development of immunosuppression and determining the disease severity and its progression

Neuropsychological evaluation of cognitive disorders in children after COVID-19

The article presents the results of neuropsychological remote and face-to-face testing of 25 children aged 12 to 17 years in the nearest (during and 1-2 weeks after the treatment) and later period (2-12 months) after COVID-19 infection with predominant respiratory tract infection, organized in Ekaterinburg in the State Autonomous Institution "Children's Hospital № 8". Indication of family contact with patients with a new coronavirus infection was found in all patients, a positive nasopharyngeal swab for SARS-CoV-2 RNA by PCR was found in 58%, non-focal neurological complaints were found in 54% of children. The control group consisted of 25 pupils of Moscow comprehensive schools (14 girls and 11 boys) aged between 12 and 16 years who were examined before the pandemic. The methods included: investigation of the kinesthetic, spatial, dynamic, graphic praxis; auditory-motor coordination; visual, object-constructive gnosis; auditory-speech, visual memory; voluntary attention; thinking. Significant differences with the results of neuropsychological tests performed in children in the control group were found, allowing us to assert impairment of memory, attention, visual gnosis, visual-spatial function, kinesthetic and dynamic praxis, verbal and non-verbal component of thinking. According to A.R. Luria's theory, the topic of the disorders involves the temporo-parieto-occipital, mediobasal, frontotemporal parts of the brain, the reticular formation and limbic structures. This necessitates the development of corrective educational programs and an in-depth diagnostic algorithm that determines the morphological substrate of cognitive disorders in children, who have undergone COVID-19. © 2022 PAGEPress Publications. All rights reserved.Ministry of Health of the Russian FederationPirogov Russian National Research Medical University, RNRMUThe study was funded by Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Moscow