Rancang Bangun Aplikasi Data Mining untuk Memprediksi Hasil Belajar Siswa Sekolah Menengah Atas Berbasis Web dengan Algoritma K-NN (Studi Kasus: SMKN 2 Pekanbaru)

Curriculum 2013 (K-13) was first announced in 2014 which has been applied to number of schools. Preparation of this new curriculum by the government aimed at making education in Indonesia is not only focused on cognitive aspects or skills possessed, but also at students' interest and motivation. Unfortunately, behind the goal, there are issues occured in the school during the application of K-13. Those are input process and values conversion that takes relatively much time. The things are caused by the dissimilarity of the standards and the assessment scale between current curriculum with the previous one. Meanwhile, the academic system running in schools is still pretty conventional. Therefore, this research will construct an application which have capability to handle the things. Beside those additional features, this research is build an application in order to apply the data mining with k-NN algorithm to predict students learning outcomes based on certain subjects. Data source that used in this research were consisted into 500 data training that covered up all classes or labels. Testing methods which have been applied are black box testing and confusion matrix. There are 3 techniques of black box testing that applied in order to test the system functionality according to its input values. Those are equivalence class partitioning, boundary value analysis and decision table based testing. Meanwhile in confusion matrix, it has been done 3 times testing according by k value in k-NN algorithm. With k-5 acquired accurate rate 79.34%, k-10 with accurate rate 62.67%, then k-15 with accurate rate 64%. Thus, information that can conluded from those testing methods is the algorithm with k-5 is more accurate than any others

Aplikasi Pengenalan Nama Surah pada Juz ke 30 Kitab Suci Al-Qur'an Menggunakan Speech Recognition

Al-Qur'an is a scripture which contains the saying of Allah Subhanahu Wa Ta'aala and was revealed to Prophet Muhammad. The 30th juz is the juz that exists in the Al-Qur'an. When studying how to read Al-Qur'an well, the first thing that is learned is reading and memorizing surahs in the 30th juz. Nevertheless, there is a problem in remembering or knowing the surah name and the verse which are in the 30th juz. An android application was developed in order to recognize the surah names in the 30th juz by utilizing speech recognition technology to overcome that problem. Markov Model (Markov Chain) algorithm was implemented in this application. This algorithm will process user's speech and compute probability of the surah name that was spoken. Speech detection testing gave result that the highest accuracy of application in recognizing the speeches was in the environment without noise with the accuracy of 100% in the most ideal distance is 50 cm for male and for female user. Based on the blackbox testing result, all functionalities of the application have functionated well. Control flow testing gave result that the value is 7 which indicates that the code is simple and well written. 87,74% respondents answered, by filling up the questionnaires, that the application is useful in order to make user knows better about the surah names in the 30th juz

8-amino-6-methoxyquinoline-tetrazole hybrids: Impact of linkers on antiplasmodial activity

A new series of compounds was prepared from 6-methoxyquinolin-8-amine or its N-(2-aminoethyl) analogue via Ugi-azide reaction. Their linkers between the quinoline and the tert-butyltetrazole moieties differ in chain length, basicity and substitution. Compounds were tested for their antiplasmodial activity against Plasmodium falciparum NF54 as well as their cytotoxicity against L-6-cells. The activity and the cytotoxicity were strongly influenced by the linker and its substitution. The most active compounds showed good activity and promising selectivity

Synthesis and antiprotozoal activity of azabicyclo-nonane pyrimidine hybrids

2,4-Diaminopyrimidines and (dialkylamino)azabicyclo-nonanes possess activity against protozoan parasites. A series of fused hybrids were synthesized and tested in vitro against pathogens of malaria tropica and sleeping sickness. The activities and selectivities of compounds strongly depended on the substitution pattern of both ring systems as well as on the position of the nitrogen atom in the bicycles. The most promising hybrids of 3-azabicyclo-nonane with 2-aminopyrimidine showed activity against P. falciparum NF54 in submicromolar concentration and high selectivity. A hybrid with pyrrolidino substitution of the 2-azabicyclo-nonane as well as of the pyrimidine moiety exhibited promising activity against the multiresistant K1 strain of P. falciparum. A couple of hybrids of 2-azabicyclo-nonanes with 2-(dialkylamino)pyrimidines possessed high activity against Trypanosoma brucei rhodesiense STIB900 and good selectivity

Benzyl- and dibenzyl tetrahydropyridinylidene ammonium salts with antiplasmodial and antitrypanosomal activity

Several 1-benzyl and 1,3-dibenzyl derivatives of tetrahydropyridinylidene salts with differing electron withdrawing substituents at the aromatic residues have been prepared. In addition, the amine moiety in position 4 was varied. The new compounds were investigated for their antiplasmodial and antitrypanosomal activities as well as for their cytotoxicity. They were characterized using FT-IR, HRMS and NMR spectroscopy. Structure-activity relationships including reported compounds are discussed. Graphical abstract: [Figure not available: see fulltext.]. © 2022, The Author(s)

New acyl derivatives of 3-aminofurazanes and their antiplasmodial activities

An N-acylated furazan-3-amine of a Medicines for Malaria Venture (MMV) project has shown activity against different strains of Plasmodium falciparum. Seventeen new derivatives were prepared and tested in vitro for their activities against blood stages of two strains of Plasmodium falciparum. Several structure-activity relationships were revealed. The activity strongly depended on the nature of the acyl moiety. Only benzamides showed promising activity. The substitution pattern of their phenyl ring affected the activity and the cytotoxicity of compounds. In addition, physicochemical parameters were calculated (log P, log D, ligand efficiency) or determined experimentally (permeability) via a PAMPA. The N-(4-(3,4-diethoxyphenyl)-1,2,5-oxadiazol-3-yl)-3-(trifluoromethyl)benzamide possessed good physicochemical properties and showed high antiplasmodial activity against a chloroquine-sensitive strain (IC50(NF54) = 0.019 microM) and even higher antiplasmodial activity against a multiresistant strain (IC50(K1) = 0.007 microM). Compared to the MMV compound, the permeability and the activity against the multiresistant strain were improved

New 2‑aminopyrimidine derivatives and their antitrypanosomal and antiplasmodial activities

Novel 2-aminopyrimidine derivatives were prepared from acyclic starting materials, benzylidene acetones and ammonium thiocyanates, via 5 steps, including ring closure, aromatization, S-methylation, oxidation to methylsulfonyl compounds, and formation of guanidines with suitable amines. The prepared compounds differ from each other by the substitutions of their amino group and of their phenyl ring. The 2-aminopyrimidines were tested by use of microplate assays for their in vitro activities against a causative organism of sleeping sickness, Trypanosoma brucei rhodesiense, as well as against a causative organism of malaria, Plasmodium falciparum NF54. Their cytotoxic properties were determined with L-6 cells (rat skeletal myoblasts). Some of the compounds exhibited quite good antitrypanosomal activity, and others showed excellent antiplasmodial activity. The influence of the structural modifications on these activities is discussed

Antiprotozoal activity of azabicyclo-nonanes linked to tetrazole or sulfonamide cores

N-(Aminoalkyl)azabicyclo[3.2.2]nonanes possess antiplasmodial and antitrypanosomal activity. A series with terminal tetrazole or sulfonamido partial structure was prepared. The structures of all new compounds were confirmed by NMR and IR spectroscopy and by mass spectral data. A single crystal structure analysis enabled the distinction between isomers. The antiprotozoal activities were examined in vitro against strains of Plasmodium falciparum and Trypanosoma brucei rhodesiense (STIB 900). The most active sulfonamide and tetrazole derivates showed activities in the submicromolar range

Synthesis and structure-activity relationships of new 2-phenoxybenzamides with antiplasmodial activity

The 2-phenoxybenzamide 1 from theMedicines for Malaria Venture Malaria Box Project has shown promising multi-stage activity against different strains of P. falciparum. It was successfully synthesized via a retrosynthetic approach. Subsequently, twenty-one new derivatives were prepared and tested for their in vitro activity against blood stages of the NF54 strain of P. falciparum. Several insights into structure-activity relationships were revealed. The antiplasmodial activity and cytotoxicity of compounds strongly depended on the substitution pattern of the anilino partial structure as well as on the size of substituents. The diaryl ether partial structure had further impacts on the activity. Additionally, several physicochemical and pharmacokinetic parameters were calculated (log P, log D7.4 and ligand efficiency) or determined experimentally (passive permeability and CYP3A4 inhibition). The tertbutyl- 4-{4-[2-(4-fluorophenoxy)-3-(trifluoromethyl)benzamido]phenyl}piperazine-1-carboxylate possesses high antiplasmodial activity against P. falciparum NF54 (PfNF54 IC50 = 0.2690 M) and very low cytotoxicity (L-6 cells IC50 = 124.0 M) resulting in an excellent selectivity index of 460. Compared to the lead structure 1 the antiplasmodial activity was improved as well as the physicochemical and some pharmacokinetic parameters