Vector mesons in qqˉqˉq\bar q\bar q systems

A new selection rule is described for the vector mesons in the decuplet representations of flavor SU(3)Comment: 7 pages and 1 figur

The ALICE CPV Detector

The Charged-Particle Veto (CPV) detector of ALICE at the LHC is presented. Physics motivation for the detector, its construction and operation in physics runs are shortly discussed. Readout electronics and data taking conditions are described. Special attention is focused on CPV automation via the detector control system. Different states of the detector and protection algorithms implemented into the control system are described

Formation of Centauro and Strangelets in Nucleus-Nucleus Collisions at the LHC and their Identification by the ALICE Experiment

We present a phenomenological model which describes the formation of a Centauro fireball in nucleus-nucleus interactions in the upper atmosphere and at the LHC, and its decay to non-strange baryons and Strangelets. We describe the CASTOR detector for the ALICE experiment at the LHC. CASTOR will probe, in an event-by-event mode, the very forward, baryon-rich phase space 5.6 < \eta < 7.2 in 5.5 A TeV central Pb + Pb collisions. We present results of simulations for the response of the CASTOR calorimeter, and in particular to the traversal of Strangelets.Comment: 4 pages, 4 figures, to appear in the proceedings of the 26th ICR

CASTOR: Centauro and Strange Object Research in nucleus-nucleus collisions at LHC

We describe the CASTOR detector designed to probe the very forward, baryon-rich rapidity region in nucleus-nucleus collisions at the LHC. We present a phenomenological model describing the formation of a QGP fireball in a high baryochemical potential environment, and its subsequent decay into baryons and strangelets. The model explains Centauros and the long-penetrating component and makes predictions for the LHC. Simulations of Centauro-type events were done. To study the response of the apparatus to new effects different exotic species (DCC, Centauros, strangelets etc.) were passed through the deep calorimeter. The energy deposition pattern in the calorimeter appears to be a new clear signature of the QGP.Comment: Talk given by E. Gladysz-Dziadus for the CASTOR group, Intern. Workshop on Nuclear Theory, 10-15 June, 2002, Bulgaria, Rila Mountains, 15 pages, 14 figure

Proposed Search for a00(980)−f0(980)a^0_0(980)-f_0(980) Mixing in Polarization Phenomena

The $K^+$ and $K^0$ meson mass difference induces the mixing of the $a^0_0(980)$ and $f_0(980)$ resonances, the amplitude of which, between the $K^+K^-$ and $K^0\bar K^0$ thresholds, is large in magnitude, of the order of $m_{K}\sqrt{m^2_{K^0}-m^2_{K^+}}\approx\sqrt\alpha m^2_K$, and possesses the phase sharply varying by about 90$^\circ$. We suggest performing the polarized target experiments on the reaction $\pi^-p\to\eta\pi^0n$ at high energy in which the fact of the existence of $a^0_0(980)-f_0(980)$ mixing can be unambiguously and very easily established through the presence of a strong jump in the azimuthal asymmetry of the $\eta\pi^0$ $S$ wave production cross section near the $K\bar K$ thresholds. The presented estimates of the polarization effect to be expected in experiment are to a great extent model independent.Comment: RevTeX, 9 pages, 1 figure. A number of typographical and grammatical errors correcte

Model of Centauro and strangelet production in heavy ion collisions

We discuss the phenomenological model of Centauro event production in relativistic nucleus-nucleus collisions. This model makes quantitative predictions for kinematic observables, baryon number and mass of the Centauro fireball and its decay products. Centauros decay mainly to nucleons, strange hyperons and possibly strangelets. Simulations of Centauro events for the CASTOR detector in Pb-Pb collisions at LHC energies are performed. The signatures of these events are discussed in detail.Comment: 19 pages, LaTeX+revtex4, 14 eps-figures and 3 table

Human Placental Syncytiotrophoblasts Restrict Toxoplasma gondii Attachment and Replication and Respond to Infection by Producing Immunomodulatory Chemokines

Toxoplasma gondii is a major source of congenital disease worldwide, but the cellular and molecular factors associated with its vertical transmission are largely unknown. In humans, the placenta forms the key interface between the maternal and fetal compartments and forms the primary barrier that restricts the hematogenous spread of microorganisms. Here, we utilized primary human trophoblast (PHT) cells isolated from full-term placentas and human midgestation chorionic villous explants to determine the mechanisms by which human trophoblasts restrict and respond to T. gondii infection. We show that placental syncytiotrophoblasts, multinucleated cells that are in direct contact with maternal blood, restrict T. gondii infection at two distinct stages of the parasite lytic cycle—at the time of attachment and also during intracellular replication. Utilizing comparative transcriptome sequencing (RNA-seq) transcriptional profiling, we also show that human placental trophoblasts from both the second and third trimesters respond uniquely to T. gondii infection compared to trophoblast cell lines, typified by the upregulation of several immunity-related genes. One of the most differentially induced genes was the chemokine CCL22, which relies on the secretion of a parasite effector(s) either during or after invasion for its induction. Collectively, our findings provide new insights into the mechanisms by which the human placenta restricts the vertical transmission of T. gondii at early and late stages of human pregnancy and demonstrate the existence of at least two interferon-independent pathways that restrict T. gondii access to the fetal compartment. IMPORTANCE Toxoplasma gondii is a major source of congenital disease worldwide and must breach the placental barrier to be transmitted from maternal blood to the developing fetus. The events associated with the vertical transmission of T. gondii are largely unknown. Here, we show that primary human syncytiotrophoblasts, the fetus-derived cells that comprise the primary placental barrier, restrict T. gondii infection at two distinct stages of the parasite life cycle and respond to infection by inducing a unique immunomodulatory transcriptional profile. Collectively, our findings provide important insights into the mechanisms by which human syncytiotrophoblasts restrict T. gondii infection at early and late stages of human pregnancy, identify both permissive and resistant human placental cell types, and identify the placenta-enriched signaling pathways induced in response to infection

The Expression and Localization of N-Myc Downstream-Regulated Gene 1 in Human Trophoblasts

The protein N-Myc downstream-regulated gene 1 (NDRG1) is implicated in the regulation of cell proliferation, differentiation, and cellular stress response. NDRG1 is expressed in primary human trophoblasts, where it promotes cell viability and resistance to hypoxic injury. The mechanism of action of NDRG1 remains unknown. To gain further insight into the intracellular action of NDRG1, we analyzed the expression pattern and cellular localization of endogenous NDRG1 and transfected Myc-tagged NDRG1 in human trophoblasts exposed to diverse injuries. In standard conditions, NDRG1 was diffusely expressed in the cytoplasm at a low level. Hypoxia or the hypoxia mimetic cobalt chloride, but not serum deprivation, ultraviolet (UV) light, or ionizing radiation, induced the expression of NDRG1 in human trophoblasts and the redistribution of NDRG1 into the nucleus and cytoplasmic membranes associated with the endoplasmic reticulum (ER) and microtubules. Mutation of the phosphopantetheine attachment site (PPAS) within NDRG1 abrogated this pattern of redistribution. Our results shed new light on the impact of cell injury on NDRG1 expression patterns, and suggest that the PPAS domain plays a key role in NDRG1's subcellular distribution. © 2013 Shi et al