The Role of the Lipid Profile and Oxidative Stress in Fatigue, Sleep Disorders and Cognitive Impairment in Patients with Multiple Sclerosis

The aim of this study is to investigate the relationship of the lipid profile, dysfunctional high-density lipoprotein, ischaemia-modified albumin and thiol–disulfide homeostasis with cognitive impairment, fatigue and sleep disorders in patients with multiple sclerosis. The cognitive functions of patients were evaluated with the Brief International Cognitive Assessment for Multiple Sclerosis battery. Fatigue was evaluated with the Fatigue Severity Scale and the Fatigue Impact Scale. The Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale were used to assess patients’ sleep disturbance. Peripheral blood samples were collected, and lipid levels and myeloperoxidase and paraoxonase activity were measured. The myeloperoxidase/paraoxonase ratio, which indicates dysfunctional high-density lipoprotein, was calculated. Thiol–disulfide homeostasis and ischaemia-modified albumin were measured. We did not identify any relationship between dysfunctional high-density lipoprotein and the physical disability, cognitive decline, fatigue and sleep problems of multiple sclerosis. Thiol–disulfide homeostasis was associated with cognitive scores. The shift of the balance towards disulfide was accompanied by a decrease in cognitive scores. On the other hand, we did not detect any relationship between fatigue and sleep disorders and thiol–disulfide homeostasis. Our findings revealed a possible correlation between cognitive dysfunction and thiol–disulfide homeostasis in multiple sclerosis patients

Renal complications of lipodystrophy: A closer look at the natural history of kidney disease

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144612/1/cen13732_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144612/2/cen13732.pd

Twin Pregnancy Complicated By Interlocking: A Case Report

Management of labor in multiple pregnancies is one of the most attracting subjects of obstetrics. Presentation of twin pairs is the major determinant of the route of deliv ery. In the past how to deliv er breech v ertex twin pairs was a conf licting decision. Anesthesia, technical difficulties and antibiotic options restricted the use of cesarean section. Under such circumstances ev en sacrif ication of one of the babies could be acceptable and thus mortality and morbidity was high. Recently we pref er the abdominal route f or delivery of breech vertex twins. Maternal morbidity is only slightly increased in cesarean sections when compared to vaginal deliv ery with the innovations of today. We now present a case of breech vertex twins which were interlocked during v aginal deliv ery and the f irst twin could be deliv ered up to the scapulas. The delivery of the first breech twin could be completed only after the abdominal deliv ery of the second v ertex twin. The babies both did very well in contrast to their difficult deliv ery. This condition presented a chance for us to rev iew the management of deliv ery of breech v ertex twin pairs in the literature and to present our own clinical experience

The role of maternal total testosteron, DHEAS, free androgen ındex, SHBG (sex hormone binding globulin) and estradiol levels in preeclampsia aetiopathogenesis

Amaç: Maternal total testosteron, serbest androjen indeksi, dehidroepiandrostenodion sülfat, seks hormon bağlayıcı globulin ve östradiol düzeylerinin preeklampsi etyopatogenezindeki rolünü belirlemek. Gereç ve Yöntem: Çalışmaya Mart 2003-Şubat 2004 tarihleri arasında Zeynep Kamil Kadın ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesine başvuran, maternal yaş ve gestasyonel yaş açısından eşleştirilmiş, preeklampsi tanısı alan 42 gebe ile normotensif 69 gebe dahil edildi. Preeklamptik 42 hastadan 22’si ağır preeklamptik, 20’si ise hafif preeklamptik olarak değerlendirildi. Preeklamptik ve normotensif gruplar ile ağır ve hafif preeklamptik gruplar gravida, parite, vücut kitle indeksi, total testosteron, serbest androjen indeksi, dehidroepiandrostenodion sülfat, seks hormon bağlayıcı globulin ve östradiol düzeyleri açı- sından karşılaştırıldı. Bulgular: Preeklamptik ve normotensif grup karşılaştırıldığında total testosteron düzeyleri ve vücut kitle indeksi preeklamptik grupta anlamlı olarak yüksek bulundu. Ağır ve hafif preeklamptik grup karşılaştırıldığında hiçbir parametrede anlamlı farklılık saptanmadı. Sonuç: Preeklampsi etyopatogenezinde maternal total testosteron, serbest androjen indeksi, dehidroepiandrostenodion sülfat, seks hormon bağlayıcı globulin ve östradiol düzeylerinin önemli bir rolü olmadı- ğını düşünmekteyiz.Objective: To determine the role of maternal serum total testosterone, free androgen index, dehydroepiandrostenodione sulphate, sex hormone binding globuline and estradiole levels in preeclampsia pathogenesis. Material and Methods: Forty-two preeeclamptic and 69 normotensive women with similar maternal and gestational ages applied to Zeynep Kamil Women and Children Hospital between March 2003- February 2004 were included the study. Twenty-two preeclamptic women were evaluated severe preeclamptic, while 20 preeclamptic women were evaluated mild preeclamptic. Preeclamptic group and normotensive group were compared with respect of mean gravidity, mean parity, body mass index, serum total testosterone, free androgen index, dehydroepiandrostenodione sulphate, sex hormone binding globuline and estradiole levels. In addition, comparasions of same parameters between severe preeclamptic group and mild preeclamptic group were performed. Results: In preeclamptic group, serum total testosterone levels and body mass index were significantly higher than normotensive group. There were no significant difference between severe and mild preeclamptic groups with respect of all parameters. Conclusion: Maternal serum total testosterone, free androgen index, dehydroepiandrostenodione sulphate, sex hormone binding globuline and estradiole levels do not seem to play a role in preeclampsia

The role of maternal total testosteron, DHEAS, free androgen ındex, SHBG (sex hormone binding globulin) and estradiol levels in preeclampsia aetiopathogenesis

Amaç: Maternal total testosteron, serbest androjen indeksi, dehidroepiandrostenodion sülfat, seks hormon bağlayıcı globulin ve östradiol düzeylerinin preeklampsi etyopatogenezindeki rolünü belirlemek. Gereç ve Yöntem: Çalışmaya Mart 2003-Şubat 2004 tarihleri arasında Zeynep Kamil Kadın ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesine başvuran, maternal yaş ve gestasyonel yaş açısından eşleştirilmiş, preeklampsi tanısı alan 42 gebe ile normotensif 69 gebe dahil edildi. Preeklamptik 42 hastadan 22’si ağır preeklamptik, 20’si ise hafif preeklamptik olarak değerlendirildi. Preeklamptik ve normotensif gruplar ile ağır ve hafif preeklamptik gruplar gravida, parite, vücut kitle indeksi, total testosteron, serbest androjen indeksi, dehidroepiandrostenodion sülfat, seks hormon bağlayıcı globulin ve östradiol düzeyleri açı- sından karşılaştırıldı. Bulgular: Preeklamptik ve normotensif grup karşılaştırıldığında total testosteron düzeyleri ve vücut kitle indeksi preeklamptik grupta anlamlı olarak yüksek bulundu. Ağır ve hafif preeklamptik grup karşılaştırıldığında hiçbir parametrede anlamlı farklılık saptanmadı. Sonuç: Preeklampsi etyopatogenezinde maternal total testosteron, serbest androjen indeksi, dehidroepiandrostenodion sülfat, seks hormon bağlayıcı globulin ve östradiol düzeylerinin önemli bir rolü olmadı- ğını düşünmekteyiz.Objective: To determine the role of maternal serum total testosterone, free androgen index, dehydroepiandrostenodione sulphate, sex hormone binding globuline and estradiole levels in preeclampsia pathogenesis. Material and Methods: Forty-two preeeclamptic and 69 normotensive women with similar maternal and gestational ages applied to Zeynep Kamil Women and Children Hospital between March 2003- February 2004 were included the study. Twenty-two preeclamptic women were evaluated severe preeclamptic, while 20 preeclamptic women were evaluated mild preeclamptic. Preeclamptic group and normotensive group were compared with respect of mean gravidity, mean parity, body mass index, serum total testosterone, free androgen index, dehydroepiandrostenodione sulphate, sex hormone binding globuline and estradiole levels. In addition, comparasions of same parameters between severe preeclamptic group and mild preeclamptic group were performed. Results: In preeclamptic group, serum total testosterone levels and body mass index were significantly higher than normotensive group. There were no significant difference between severe and mild preeclamptic groups with respect of all parameters. Conclusion: Maternal serum total testosterone, free androgen index, dehydroepiandrostenodione sulphate, sex hormone binding globuline and estradiole levels do not seem to play a role in preeclampsia

Uterine Junctional Zone Thickness, Cervical Length and Bioelectrical Impedance Analysis of Body Composition in Women with Endometriosis

Objective: We aimed to evaluate uterine junctional zone thickness, cervical length and bioelectrical impedance analysis of body composition in women with endometriosis.Material and Methods: This is a prospective study conducted in a tertiary teaching hospital. A total of 73 patients were included in the study. Endometriosis was surgically diagnosed in 36 patients (study group). The control group included 37 patients. Main outcome measure(s): Bioelectrical impedance analysis was used to measure body composition. Uterine junctional zone thickness and cervical length were measured by transvaginal ultrasonography.Results: Patients’ characteristics (age, gravida, parity, live baby, age of menarche, lengths of menstrual cycle , percentage of patients with dysmenorrhea, positive family history), body mass index (BMI) (kg/m2), amount of body fat (kg), percentage of body fat were not statistically different between the two groups (p>0.05). The length of menstruation and cervical length were longer in women with endometriosis. Similarly, the inner myometrium was thicker in women with endometriosis than the control group. Conclusion: The relation between endometriosis and demographic features such as age, gravida, parity, gravida, BMI, lengths of the menstrual cycle, age of menarche are controversial. Longer cervical length and thicker inner myometrial layer may be important in the etiopathogenesis of endometriosis