Validity and reliability of the Quality of Life in Reflux and Dyspepsia (QoLRAD) questionnaire in patients with gastroesophageal reflux disease for the Turkish population

WOS: 000469770400003PubMed ID: 31144656Background/Aims: Gastroesophageal reflux disease negatively affects quality of life. The aim is to improve quality of life because of high recurrence rate. There is a strong need for patient-reported outcome measures. The present study aimed to evaluate the validity and reliability of the Quality of Life in Reflux and Dyspepsia Questionnaire (QoLRAD) to adopt it into Turkish. Materials and Methods: A total of 142 patients with complaints of heartburn or regurgitation once a week or commonly diagnosed with 24-hour intraesophageal impedance-pH monitoring and/or upper gastrointestinal endoscopy were included in this study. Sociodemographic Data Collection Form, QoLRAD-TR, and Short Form-36 (SF-36) were applied to patients who were off proton pump inhibitors. Results: The Cronbach's alpha coefficient value of the questionnaire was 0.97, and the intraclass correlation coefficient (ICC) value of the result of test-retest method was between 0.97 (Vitality) and 0.99 (Eating/Drinking Disorders). There was a positive correlation between all subdomains of QoLRAD-TR and SF-36 scales. The lowest correlation (0.10) was between Emotional Distress and Role-emotional Limitations, and the highest (0.34) was between Energy and Vitality. Conclusion: The QoLRAD test measuring quality of life, except some subdomains in our study that we performed on patients diagnosed with GERD, was found to be valid and reliable

Evaluation of Spontaneous Spinal Cerebrospinal Fluid Leaks Disease by Computerized Image Processing

Background: Spontaneous Spinal Cerebro spinal Fluid Leaks (SSCFL) is a disease based on tears on the dura mater. Due to widespread symptoms and low frequency of the disease, diagnosis is problematic. Diagnostic lumbar puncture is commonly used for diagnosing SSCFL, though it is invasive and may cause pain, inflammation or new leakages. T2-weighted MR imaging is also used for diagnosis; however, the literature on T2-weighted MRI states that findings for diagnosis of SSCFL could be erroneous when differentiating the diseased and control. One another technique for diagnosis is CT-myelography, but this has been suggested to be less successful than T2-weighted MRI and it needs an initial lumbar puncture

Giant fibroepithelial polyp of the perineum

Introduction: Fibroepitheial polyps (FEP) are among the most common benign skin lesions and definitive histology is often needed to exclude malignancy. These polyps are usually less than 5 cm in size and are often seen in genito-urinary sites including the perineum. A small number can reach a significant size. Presentation of case: A 46-year-old female patient presented with a pedunculated mass measuring 18 cm in diameter, localized to the left perineum. The lesion was excised and the histopathological diagnosis was fibroepithelial polyp. Conclusion: We present this case as the third largest FEP recorded in the available literature

Endorectal ultrasonography versus phased-array magnetic resonance imaging for preoperative staging of rectal cancer

AIM: To compare the diagnostic accuracy of pelvic phased-array magnetic resonance imaging (MRI) and endorectal ultrasonography (ERUS) in the preoperative staging of rectal carcinoma

Foreign Material in the Gastrointestinal Tract: Cocaine Packets

Smuggling drugs by swallowing or inserting into a body cavity is not only a serious and growing international crime, but can also lead to lethal medical complications. The most common cause of death in ‘body packers', people transporting drugs by ingesting a packet into the gastrointestinal tract, is acute drug toxicity from a ruptured packet. However, more than 30 years after the initial report of body packing, there is still no definitive treatment protocol for the management of this patient group. The treatment strategy is determined according to the particular condition of the patient and the clinical experience of the treatment center. Surgical intervention is also less common now, due to both the use of improved packaging materials among smugglers and a shift towards a more conservative medical approach. Herein, we report a case of toxicity from ingested packets of cocaine that leaked and, despite surgery, resulted in exitus of the patient

Synthesis and antibacterial activity of new hydrazide-hydrazones derived from Benzocaine

A novel series of new eleven benzocaine hydrazide derivatives, N-(4-{[2-(nonsubstituted/ substitutedfuryl/ phenyl/ pyridinyl/ thienyl/ pyrrole) methylidene]hydrazinyl] carbonyl} phenyl) benzamides [3a-k] have been synthesized in this study. The structures of the new compounds were determined by spectral (FT-IR and H-1-NMR) methods and their purity was proven by elemental analysis and thin layer chromatography. These compounds were evaluated for in vitro antibacterial activity by using micro-well dilution method against Escherichia coli ATCC 10536, Escherichia coli ATCC 15442, Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa ATCC 15442, Acinetobacter baumannii, Klebsiella pneumonia ATCC 13883