Synthetic interaction and focused activity in sustainment of the rational task-group

"A control of natural interaction (36 groups), a technique of simple synthetic interactivity (distributed processing - 36 groups), and a technique of synthetic interactivity which focuses individual contribution through facilitated knowledge elicitation (braided - 36 groups) were compared in the collaboration of three-member task-groups facing a complex discovered problem (Getzels, 1982). Additional structure tested factors of coactivity (same vs. separate locations) and communication modality (written vs. oral). The task involved management (public policy) of a simulated city facing the onset of a health epidemic (Doerner, Schaub & Badke-Schaub, 1990). Several measures of group performance were obtained both from raw group output and resulting simulation values. Results indicate: 1.) no important differences between communication modalities or coactivity level, 2.) freely collaborating groups (control) performed similarly to randomized baseline trials of the simulation, and 3.) collaborative structure enabled large performance elevation with braided groups outperforming distributed groups and both techniques outperforming the control." (author's abstract

Requirements for an Inductive Voltage Adder as Driver for a Kicker Magnet with Short Circuit Termination

At CERN pulse generators based on Thyratron switches and SF6 gas filled pulse forming lines, used for driving kicker magnets, are to be replaced with semiconductor technology. Preliminary investigations show the inductive voltage adder is suitable as a pulse generator for this application. To increase the magnetic field without raising the system voltage, a short-circuit termination is often applied to a kicker magnet. Because of the electrical length of a transmission line magnet, wave propagation needs to be considered. To allow for the wavefront reflected from the short-circuit termination back to the generator, a novel approach for an inductive adder architecture has been investigated. It is based on a modified generator interface, circulating the current back into the load, until the stored energy is absorbed at the end of the pulse. This approach allows for a smaller magnetic core size compared to a conventional design with a matched load. Moreover, it enables more energy-efficient operation involving smaller storage capacitors. This paper summarizes the conceptual design features and furthermore gives an overview of the parameter space for possible applications at CERN

"How Did They Come Across?" Lessons Learned from Continuous Affective Ratings

Social distance, or perception of the other, is recognized as a dynamic dimension of an interaction, but yet to be widely explored or understood. Through CORAE, a novel web-based open-source tool for COntinuous Retrospective Affect Evaluation, we collected retrospective ratings of interpersonal perceptions between 12 participant dyads. In this work, we explore how different aspects of these interactions reflect on the ratings collected, through a discourse analysis of individual and social behavior of the interactants. We found that different events observed in the ratings can be mapped to complex interaction phenomena, shedding light on relevant interaction features that may play a role in interpersonal understanding and grounding. This paves the way for better, more seamless human-robot interactions, where affect is interpreted as highly dynamic and contingent on interaction history.Comment: arXiv admin note: substantial text overlap with arXiv:2306.1662

CORAE: A Tool for Intuitive and Continuous Retrospective Evaluation of Interactions

This paper introduces CORAE, a novel web-based open-source tool for COntinuous Retrospective Affect Evaluation, designed to capture continuous affect data about interpersonal perceptions in dyadic interactions. Grounded in behavioral ecology perspectives of emotion, this approach replaces valence as the relevant rating dimension with approach and withdrawal, reflecting the degree to which behavior is perceived as increasing or decreasing social distance. We conducted a study to experimentally validate the efficacy of our platform with 24 participants. The tool's effectiveness was tested in the context of dyadic negotiation, revealing insights about how interpersonal dynamics evolve over time. We find that the continuous affect rating method is consistent with individuals' perception of the overall interaction. This paper contributes to the growing body of research on affective computing and offers a valuable tool for researchers interested in investigating the temporal dynamics of affect and emotion in social interactions

Household Transmission of Rotavirus in a Community with Rotavirus Vaccination in Quininde, Ecuador

Background: We studied the transmission of rotavirus infection in households in peri-urban Ecuador in the vaccination era. Methods: Stool samples were collected from household contacts of child rotavirus cases, diarrhea controls and healthy controls following presentation of the index child to health facilities. Rotavirus infection status of contacts was determined by RT-qPCR. We examined factors associated with transmissibility (index-case characteristics) and susceptibility (householdcontact characteristics). Results: Amongst cases, diarrhea controls and healthy control household contacts, infection attack rates (iAR) were 55%, 8% and 2%, (n = 137, 130, 137) respectively. iARs were higher from index cases with vomiting, and amongst siblings. Disease ARs were higher when the index child was ,18 months and had vomiting, with household contact ,10 years and those sharing a room with the index case being more susceptible. We found no evidence of asymptomatic infections leading to disease transmission. Conclusion: Transmission rates of rotavirus are high in households with an infected child, while background infections are rare. We have identified factors associated with transmission (vomiting/young age of index case) and susceptibility (young age/sharing a room/being a sibling of the index case). Vaccination may lead to indirect benefits by averting episodes or reducing symptoms in vaccinees

Cardiac MR Elastography: Comparison with left ventricular pressure measurement

Purpose of the Study: To compare magnetic resonance elastography (MRE) with ventricular pressure changes in an animal model. Methods: Three pigs of different cardiac physiology (weight, 25 to 53 kg; heart rate, 61 to 93 bpm; left ventricular [LV] end-diastolic volume, 35 to 70 ml) were subjected to invasive LV pressure measurement by catheter and noninvasive cardiac MRE. Cardiac MRE was performed in a short-axis view of the heart and applying a 48.3-Hz shear-wave stimulus. Relative changes in LV-shear wave amplitudes during the cardiac cycle were analyzed. Correlation coefficients between wave amplitudes and LV pressure as well as between wave amplitudes and LV diameter were determined. Results: A relationship between MRE and LV pressure was observed in all three animals (R-square [greater than or equal to] 0.76). No correlation was observed between MRE and LV diameter (R-square [less than or equal to] 0.15). Instead, shear wave amplitudes decreased 102 +/- 58 ms earlier than LV diameters at systole and amplitudes increased 175 +/- 40 ms before LV dilatation at diastole. Amplitude ratios between diastole and systole ranged from 2.0 to 2.8, corresponding to LV pressure differences of 60 to 73 mmHg. Conclusion: Externally induced shear waves provide information reflecting intraventricular pressure changes which, if substantiated in further experiments, has potential to make cardiac MRE a unique noninvasive imaging modality for measuring pressure-volume function of the heart

Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

Nitrite (NO2−) is an intrinsic signaling molecule that is reduced to NO during ischemia and limits apoptosis and cytotoxicity at reperfusion in the mammalian heart, liver, and brain. Although the mechanism of nitrite-mediated cytoprotection is unknown, NO is a mediator of the ischemic preconditioning cell-survival program. Analogous to the temporally distinct acute and delayed ischemic preconditioning cytoprotective phenotypes, we report that both acute and delayed (24 h before ischemia) exposure to physiological concentrations of nitrite, given both systemically or orally, potently limits cardiac and hepatic reperfusion injury. This cytoprotection is associated with increases in mitochondrial oxidative phosphorylation. Remarkably, isolated mitochondria subjected to 30 min of anoxia followed by reoxygenation were directly protected by nitrite administered both in vitro during anoxia or in vivo 24 h before mitochondrial isolation. Mechanistically, nitrite dose-dependently modifies and inhibits complex I by posttranslational S-nitrosation; this dampens electron transfer and effectively reduces reperfusion reactive oxygen species generation and ameliorates oxidative inactivation of complexes II–IV and aconitase, thus preventing mitochondrial permeability transition pore opening and cytochrome c release. These data suggest that nitrite dynamically modulates mitochondrial resilience to reperfusion injury and may represent an effector of the cell-survival program of ischemic preconditioning and the Mediterranean diet

Propionate functions as a feeding state-dependent regulatory metabolite to counter proinflammatory signaling linked to nutrient load and obesity.

The authors thank Drs. Antonio Murgia and Ben McNally of the University of Cambridge Biochemistry Department for their contributions to metabolomics and lipidomic data processing. They thank and acknowledge the assistance of the National Heart, Lung, and Blood Institute DNA Sequencing and Genomics Core in performing the RNA library sequencing and the National Heart, Lung, and Blood Institute Flow Cytometry Core for performing the flow cytometry.Peer reviewe

Global change drivers and the risk of infectious disease

Anthropogenic change is contributing to the rise in emerging infectious diseases, but it remains unclear which global change drivers most increase disease and under what contexts. We amassed a dataset from the literature that includes 1,832 observations of infectious disease responses to global change drivers across 1,202 host-parasite combinations. We found that biodiversity loss, climate change, and introduced species were associated with increases in disease-related endpoints or harm (i.e., enemy release for introduced species), whereas urbanization was associated with decreases in disease endpoints. Natural biodiversity gradients, deforestation, forest fragmentation, and most classes of chemical contaminants had non-significant effects on these endpoints. Overall, these results were consistent across human and non-human diseases. Context-dependent effects of the global change drivers on disease were common and are discussed. These findings will help better target disease management and surveillance efforts towards global change drivers that increase disease.One-Sentence SummaryHere we quantify which global change drivers increase infectious diseases the most to better target global disease management and surveillance efforts