80 research outputs found

    Wachstumsfaktor-Rezeptoren als Vermittler UVC-induzierter Genexpression

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    Lichtspur

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    A 5-hour durational performance collaboration with artist Christoph Lammers and local musicians in St. Pauls, Munich as part of the festival Die Lange Nacht der Musik, April 201

    Lichtung

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    An exhibition project by artist Christoph Lammers with guest artists Stefanie Sachsenmaier and Mie Imori, Unicredit Kunstraum, Munich, December 201

    Tanz auf dem Vulkan (Dancing on a volcano)

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    Solo Performance Collaboration with artist Christoph Lammers Sound Simjon Spengler Drawing, movement and sound exist in the same space. A three-hour live performance installation took place at the private view on 27 April. A film of the event was screened next to the remaining charcoal wall drawing

    Spontaneous combustion

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    Collaborative performance with musician Nick Franglen and artist Christoph Lammer

    Src family kinases are required for integrin but not PDGFR signal transduction.

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    Src family kinases (SFKs) have been implicated as important regulators of ligand-induced cellular responses including proliferation, survival, adhesion and migration. Analysis of SFK function has been impeded by extensive redundancy between family members. We have generated mouse embryos harboring functional null mutations of the ubiquitously expressed SFKs Src, Yes and Fyn. This triple mutation leads to severe developmental defects and lethality by E9.5. To elucidate the molecular mechanisms underlying this phenotype, SYF cells (deficient for Src, Yes and Fyn) were derived and tested for their ability to respond to growth factors or plating on extracellular matrix. Our studies reveal that while Src, Yes and Fyn are largely dispensable for platelet-derived growth factor (PDGF)-induced signaling, they are absolutely required to mediate specific functions regulated by extracellular matrix proteins. Fibronectin-induced tyrosine phosphorylation of focal adhesion proteins, including the focal adhesion kinase FAK, was nearly eliminated in the absence of Src, Yes and Fyn. Furthermore, consistent with previous reports demonstrating the importance of FAK for cell migration, SYF cells displayed reduced motility in vitro. These results demonstrate that SFK activity is essential during embryogenesis and suggest that defects observed in SYF triple mutant embryos may be linked to deficiencies in signaling by extracellular matrix-coupled receptors
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