Revisiting the WMAP - NVSS angular cross correlation. A skeptic's view

In the context of the study of the ISW, we revisit the angular cross correlation of WMAP CMB data with the NVSS radio survey. We compute 2-point cross functions between the two surveys in real and in Fourier space, paying particular attention on the dependence of results on the flux of NVSS radio sources, the angular scales where correlations arise and the comparison with theoretical expectations. We reproduce previous results that claim an excess of correlation in the angular correlation function (ACF), and we also find some (low significance) similarity between the CMB and radio galaxy data in the multipole range \el \in [10, 25]. However, the S/N in the ACFs increases with higher flux thresholds for NVSS sources, but drops a $\sim$ 30 - 50% in separations of the order of a pixel size, suggesting some residual point source contribution. When restricting our analyses to multipoles \el \gt 60, we fail to find any evidence for cross correlation in the range \el \in [2,10], where according to the model predictions and our simulations $\sim$ 50% of the S/N is supposed to arise. Also, the accumulated S/N for \el \lt 60 is below 1, far from the theoretical expectation of S/N$\sim 5$. Part of this disagreement may be caused by an inaccurate modeling of the NVSS source population: as in previous works, we find a level of large scale (\el \lt 70) clustering in the NVSS catalog that seems incompatible with a high redshift population. This is unlikely to be caused by contaminants or systematics, since it is independent of flux threshold, and hence present for the brightest ($\gt 30 \sigma$) NVSS sources. Either our NVSS catalogs are not probing the high redshift, large scale gravitational potential wells, or there is a clear mismatch between the ISW component present in WMAP data and theoretical expectations.Comment: 16 pages, one extra figure (13 total), matches accepted version in A&

Energy security and shifting modes of governance

The concept of energy security fits uneasily into contemporary security debates. It is neither a clearly traditional nor a fully ‘non-traditional’ security issue. There are also limits to the social constructedness of the concept. This article argues that, while it is important to identify the differing securitizations of energy, these must be contextualized within the material realities and the differing historical modes of governance of the political economy of resources. This is essential for understanding the differing meanings accorded to energy security, the shifting modes through which energy is governed, and the extent to which energy security concerns drive international politics. In this context, contemporary concerns over energy security have both material and ideological dimensions: anxiety over the dual shift of power from West to East and from resource-importing to resource-exporting countries; and concern over the normative weakening of the neo-liberal mode of energy governance

Directed Evolution Generates a Novel Oncolytic Virus for the Treatment of Colon Cancer

Background Viral-mediated oncolysis is a novel cancer therapeutic approach with the potential to be more effective and less toxic than current therapies due to the agents selective growth and amplification in tumor cells. To date, these agents have been highly safe in patients but have generally fallen short of their expected therapeutic value as monotherapies. Consequently, new approaches to generating highly potent oncolytic viruses are needed. To address this need, we developed a new method that we term “Directed Evolution” for creating highly potent oncolytic viruses. Methodology/Principal Findings Taking the “Directed Evolution” approach, viral diversity was increased by pooling an array of serotypes, then passaging the pools under conditions that invite recombination between serotypes. These highly diverse viral pools were then placed under stringent directed selection to generate and identify highly potent agents. ColoAd1, a complex Ad3/Ad11p chimeric virus, was the initial oncolytic virus derived by this novel methodology. ColoAd1, the first described non-Ad5-based oncolytic Ad, is 2–3 logs more potent and selective than the parent serotypes or the most clinically advanced oncolytic Ad, ONYX-015, in vitro. ColoAd1's efficacy was further tested in vivo in a colon cancer liver metastasis xenograft model following intravenous injection and its ex vivo selectivity was demonstrated on surgically-derived human colorectal tumor tissues. Lastly, we demonstrated the ability to arm ColoAd1 with an exogenous gene establishing the potential to impact the treatment of cancer on multiple levels from a single agent. Conclusions/Significance Using the “Directed Evolution” methodology, we have generated ColoAd1, a novel chimeric oncolytic virus. In vitro, this virus demonstrated a >2 log increase in both potency and selectivity when compared to ONYX-015 on colon cancer cells. These results were further supported by in vivo and ex vivo studies. Furthermore, these results have validated this methodology as a new general approach for deriving clinically-relevant, highly potent anti-cancer virotherapies