Book review: news, numbers and public opinion in a data-driven world edited by An Nguyen

In News, Numbers and Public Opinion in a Data-Driven World, An Nguyen brings together contributors to showcase international research on the integration of statistical reasoning in journalistic education, production and consumption. In a data-driven context marked by concerns about fake news, ‘post-truth’ and the spread of disinformation, this is a thoughtful and accessible contribution to understanding the role of numeracy in contemporary journalism, recommends Sabrina Wilkinson

Book review: the circulation of anti-austerity protest by Bart Cammaerts

In The Circulation of Anti-Austerity Protest, Bart Cammaerts examines how protest circulates in society, drawing on an investigation into the UK anti-austerity movement following the 2008 financial crisis. Proposing the ‘circuit of protest’ as a novel theoretical framework, this engaging and informative book offers rich insights into how social movements engage with communication technologies and processes, finds Sabrina Wilkinson

The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities

Uncontrolled host immunological reactions directed against tissue-trapped eggs precipitate a potentially lethal, pathological cascade responsible for schistosomiasis. Blocking schistosome egg production, therefore, presents a strategy for simultaneously reducing immunopathology as well as limiting disease transmission in endemic or emerging areas. We recently demonstrated that the ribonucleoside analogue 5-azacytidine (5-AzaC) inhibited Schistosoma mansoni oviposition, egg maturation and ovarian development. While these anti-fecundity effects were associated with a loss of DNA methylation, other molecular processes affected by 5-AzaC were not examined at the time. By comparing the transcriptomes of 5-AzaC-treated females to controls, we provide evidence that this ribonucleoside analogue also modulates other crucial aspects of schistosome egg-laying biology. For example, S. mansoni gene products associated with amino acid-, carbohydrate-, fatty acid-, nucleotide- and tricarboxylic acid (TCA)- homeostasis are all dysregulated in 5-AzaC treated females. To validate the metabolic pathway most significantly affected by 5-AzaC, amino acid metabolism, nascent protein synthesis was subsequently quantified in adult schistosomes. Here, 5-AzaC inhibited this process by 68% ?16.7% (SEM) in male- and 81% ?4.8% (SEM) in female-schistosomes. Furthermore, the transcriptome data indicated that adult female stem cells were also affected by 5-AzaC. For instance, 40% of transcripts associated with proliferating schistosome cells were significantly down-regulated by 5-AzaC. This finding correlated with a considerable reduction (95%) in the number of 5-ethynyl-2?-deoxyuridine (EdU) positive cells found in 5-AzaC-treated females. In addition to protein coding genes, the effect that 5-AzaC had on repetitive element expression was also assessed. Here, 46 repeats were found differentially transcribed between 5-AzaC-treated and control females with long terminal repeat (LTR) and DNA transposon classes being amongst the most significant. This study demonstrates that the anti-fecundity activity of 5-AzaC affects more than just DNA methylation in schistosome parasites. Further characterisation of these processes may reveal novel targets for schistosomiasis controlauthorsversionPeer reviewe

Towards an Understanding of Changing-Look Quasars: An Archival Spectroscopic Search in SDSS

The uncertain origin of the recently-discovered `changing-looking' quasar phenomenon -- in which a luminous quasar dims significantly to a quiescent state in repeat spectroscopy over ~10 year timescales -- may present unexpected challenges to our understanding of quasar accretion. To better understand this phenomenon, we take a first step to building a sample of changing-look quasars with a systematic but simple archival search for these objects in the Sloan Digital Sky Survey Data Release 12. By leveraging the >10 year baselines for objects with repeat spectroscopy, we uncover two new changing-look quasars, and a third discovered previously. Decomposition of the multi-epoch spectra and analysis of the broad emission lines suggest that the quasar accretion disk emission dims due to rapidly decreasing accretion rates (by factors of >2.5), while disfavoring changes in intrinsic dust extinction for the two objects where these analyses are possible. Broad emission line energetics also support intrinsic dimming of quasar emission as the origin for this phenomenon rather than transient tidal disruption events or supernovae. Although our search criteria included quasars at all redshifts and transitions from either quasar-like to galaxy-like states or the reverse, all of the clear cases of changing-look quasars discovered were at relatively low-redshift (z ~ 0.2 - 0.3) and only exhibit quasar-like to galaxy-like transitions.Comment: 15 pages, 8 figures. Updated to accepted versio

The modulatory role of sulfated and non-sulfated small molecule heparan sulfate-glycomimetics in endothelial dysfunction:absolute structural clarification, molecular docking and simulated dynamics, SAR analyses and ADME studies

The conceptual technology of small molecule glycomimetics, exemplified by compounds C1–4, has shown promising protective effects against lipid-induced endothelial dysfunction, restorative effects on diabetic endothelial colony forming cells, and preventative effects on downstream vascular calcification amongst other important in vitro and ex vivo studies. We report the optimised synthesis of an array of 17 small molecule glycomimetics, including the regio-, enantio- and diastereo-meric sulfated scaffolds of a hit structure along with novel desulfated examples. For the first time, the absolute stereochemical configurations of C1–4 have been clarified based on an identified and consistent anomaly with the Sharpless asymmetric dihydroxylation reaction. We have investigated the role and importance of sulfation pattern, location, regioisomers, and spatial orientation of distal sulfate groups on the modulation of endothelial dysfunction through their interaction with hepatocyte growth factor (HGF). In silico studies demonstrated the key interactions the persulfated glycomimetics make with HGF and revealed the importance of both sulfate density and positioning (both point chirality and vector) to biological activity. In vitro biological data of the most efficient binding motifs, along with desulfated comparators, support the modulatory effects of sulfated small molecule glycomimetics in the downstream signaling cascade of endothelial dysfunction. In vitro absorption, distribution, metabolism, elimination and toxicity (ADMET) data demonstrate the glycomimetic approach to be a promising approach for hit-to-lead studies

P-MaNGA : full spectral fitting and stellar population maps from prototype observations

MC acknowledges support from a Royal Society University Research Fellowship.MaNGA (Mapping Nearby Galaxies at Apache Point Observatory) is a 6-yearSDSS-IV survey that will obtain resolved spectroscopy from 3600 Å to10300 Å for a representative sample of over 10,000 nearby galaxies.In this paper, we derive spatially resolved stellar population properties and radial gradients by performing full spectral fitting of observed galaxy spectra from P-MaNGA, a prototype of the MaNGA instrument. These data include spectra for eighteen galaxies, covering a large range of morphological type. We derive age, metallicity, dust and stellar mass maps, and their radial gradients, using high spectral-resolution stellar population models, and assess the impact of varying the stellar library input to the models. We introduce a method to determine dust extinction which is able to give smooth stellar mass maps even in cases of high and spatially non-uniform dust attenuation.With the spectral fitting we produce detailed maps of stellar population properties which allow us to identify galactic features among this diverse sample such as spiral structure, smooth radial profiles with little azimuthal structure in spheroidal galaxies, and spatially distinct galaxy sub-components. In agreement with the literature, we find the gradients for galaxies identified as early-type to be on average flat in age, and negative (- 0.15 dex / Re ) in metallicity,whereas the gradients for late-type galaxies are on average negative in age (- 0.39 dex / Re ) and flat in metallicity. We demonstrate howdifferent levels of data quality change the precision with which radialgradients can be measured. We show how this analysis, extended to thelarge numbers of MaNGA galaxies, will have the potential to shed lighton galaxy structure and evolution.PostprintPeer reviewe