Analisis Kebutuhan Tempat Tidur Di Bangsal Merak RSUP Dr. Kariadi Semarang Tahun 2022-2024

The hospital as a complete health service unit is currently undergoing development where various standards are used to see the effectiveness and efficiency of health services, some of which are. are BOR and LOS. This research was conducted at RSUSP Dr. Kariadi Semarang, namely in three wards; Basic Peacock, Peacock 1, and Peacock 2. The data used in this study are data from 2017 to 2019. The method used in this study is a quantitative descriptive research method. It is known that the number of bed capacities in Dr. Kariadi did not experience an increase in the study year. In addition, the number of effective days in the three wards varied with the condition that the number of treatment days was predicted to decrease. On the other hand, the BOR is too high so it is necessary to add more beds

Morphological Characterization of Local Durian [Durio Zhibetinus] From Katingan Regency

Katingan is one of the regencies in Central Kalimantan which famous for its diversity of local durian (Durio zibethinus). The objective of the research was to determine the potential diversity of durian in Katingan. Characterization was done on the parental tree of local durian, popularly known as Durian Kasongan. Six cultivars of local durian from Katingan namely Ubuyu, Lagas, Belimbing, Susu, Bukit Lime, and Kalasi were characterized from June–November 2013 and SeptemberDecember 2014. Characterization was done using descriptor for durian. The data collected were analyzed using principal component analysis (PCA) to reduce the number of variables for genetic similarity/cluster analysis. The results showed that leaf morphology contributed to the cumulative diversity of 98.4%. In addition, the cluster analysis showed that six local durians have the genetic similarity which range of 44.90–72.45%. The highest genetic similarity was between Lagas and Susu cultivars (72.45%)

Peningkatan Aktivitas Pembelajaran Ilmu Pengetahuan Alam dengan Metode Demonstrasi pada Siswa Kelas V Sdn 23 Mempawah Hilir

The research was carried out with the aim to improve the Natural Science learning activities by using the Demonstration Method to 5th (fifth) grade student at State Elementary School Number 23 Mempawah Hilir. The common problem formulation namely Is by using the Demonstration Method able to increase the Natural Science learning activities for 5th (fifth) grade student at State Elementary School Number 23 Mempawah Hilir ? The research method applied is the Action Research Method. The research implemented for three cycles to 21 (twenty-one) students of the 5th grade at Elementary School Number 23 Mempawah Hilir. The data gathering technique is Direct Observation by using the students observation sheet tool then data acquired, reduced, presented and summarized. The research results show that increase the physical activities taken before the 1st cycle to 3rd cycle was 22,23% (very high category), the mental activities taken before the 1st cycle to 3rd cycle was 36,68% (high category) and emotional activities taken from 1st cycle to 3rd cycle was 43,37% (very high category

Development of bambangan (Mangifera pajang) carbonated drink

Mangifera pajang Kostermans or bambangan is a popular fruit among Sabahan due to its health and economic values. However, the fruit is not fully commercialized since it is usually been used as traditional cuisine by local people. Thus, development of bambangan fruit into carbonated drink was conducted to produce new product concept. The objectives of this study were to conceptualize, formulate, evaluate consumer acceptance, and determine physicochemical properties and nutritional composition of the accepted product. Method used in conceptualising the product was based on questionnaire. The consumer acceptance was evaluated based on descriptive and affective tests with four product formulations tested. The physicochemical properties on carbon dioxide volume, colour, pH, total acidity, total soluble solid (TSS) and viscosity were highlighted, meanwhile nutritional composition on fat, protein, carbohydrates and energy content were determined. About 77% respondents gave positive feedback, and 69% respondents decided this product is within their budget. The formulation of 5% bambangan pulp, 70% water, 25% sugar and 0.2% citric acid was highly accepted in descriptive and affective tests with 4.4 and 6.39 mean scores, respectively. The physicochemical properties and nutritional composition of the acceptance product were in optimum value except for colour, total acidity and TSS. Overall, this study showed that the product has high potential to be commercialized as new product concept, and heritage of indigenous people can be preserved when this fruit is known regionally

Antiproliferative activity of five garcinia species collected in Sabah, Malaysian Borneo against estrogen receptor-human breast carcinoma (MCF-7) cell line

Garcinia species are well-known for their unique properties of having natural secondary metabolite compounds called xanthone as well as their ethnomedicinal values such as antioxidant, anticancer, anti-inflammatory and antibacterial properties. The study was conducted to investigate the antiproliferative activity of peel, flesh and seed extracts of G. dulcis, G. parvifolia, G. nitida, G. mangostana var. mangosta and G. cambogia collected from Malaysian Borneo (Sabah) against estrogen receptor-positive human breast carcinoma (MCF-7) cells. The antiproliferative activity was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) assay. The results showed that G. dulcis seed induced strongest antiproliferative activity against MCF-7 cancer cell line with the IC50 value of 2.5±0.0 μg/ml, followed by G. dulcis flesh, G. mangostana var. mangostana peel and G. dulcis peel with IC50 values of 9.33 ± 3.21, 11.17 ± 1.04 and 17.67 ± 2.08 μg/ml, respectively. Meanwhile, the IC50 value for G. cambogia peel was 56.67 ± 10.5 μg/ml. No IC50 value was detected in all parts of G. parvifolia and G. nitida at concentration tested (<100 μg/ml). Overall, this study clearly showed that the whole fruit of G. dulcis displayed potent cytotoxic effect by inducing antiproliferative activity at low concentration. Further studies are needed in the future to develop this fruit as pharmaceutical and nutraceutical product for the treatment and prevention against cancer

Compact circularly polarized truncated square ring slot antenna with suppressed higher resonances

This paper presents a compact circularly polarized (CP) antenna with an integrated higher order harmonic rejection filter. The proposed design operates within the ISM band of 2.32 GHz± 2.63 GHz and is suitable for example for wireless power transfer applications. Asymmetrical truncated edges on a square ring create a defected ground structure to excite the CP property, simultaneously realizing compactness. It offers a 50.5% reduced patch area compared to a conventional design. Novel stubs and slot shapes are integrated in the transmission line to reduce higher (up to the third) order harmonics. The proposed prototype yields a -10 dB reflection coefficient (S11) impedance bandwidth of 12.53%, a 3 dB axial ratio bandwidth of 3.27%, and a gain of 5.64 dBi. Measurements also show good agreement with simulations. © 2017 Sabran et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Semecarpus euodiifolius

Semecarpus euodiifolius is uncommon and was recorded from eastern (Sandakan district) and western Sabah (Kuala Penyu, Beaufort, and Tenom). Most of the sites have been converted into palm oil plantation, except for Beaufort hill and Lumaku forest reserve (Tenom). Due to the land use change and forest fire, there is an estimated decline of 90% in extent of occurrence (EOO) and 67% in area of occupancy (AOO) across its range (based on GeoCAT reduction analysis) in 60 years. After this reduction, estimated area of occupancy (AOO) and extent of occurrence (EOO) are both 8 km2. This decline in habitat and distribution is inferred to have caused a population loss of at least 90% over the last three generations. Decline is still continuing as one site of the species remains outside of a protected area. Hence, it is assessed as Critically Endangered. Semecarpus euodifolius is endemic to Sabah, Malaysia. It was recorded from Beaufort, Tenom, and Kuala Penyu in western Sabah and from the Sandakan district in eastern Sabah. Most of the sites has been converted into palm oil plantation, except for Beaufort hill and Tenom localities

Semecarpus impressicostatus

Semecarpus impressicostatus is restricted to the Telupid-Tongod area in eastern Sabah. The estimated area of occupancy (AOO) and extent of occurrence (EOO) are 12 km2 and 779 km2, respectively. It is known from three sites, two of which are within Totally Protected Areas (TPAs), however, forest fire remains a threat to these individuals as the sites are close to the border of the reserve. Land use change is a major threat to the subpopulation outside of the protected areas. Hence, it is assessed as Endangered. Semecarpus impressicostatus is endemic to Sabah, Malaysia. It is restricted to the Telupid-Tongod area in eastern Sabah

Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition

Hedgehog signaling drives oncogenesis in several cancers and strategies targeting this pathway have been developed, most notably through inhibition of Smoothened. However, resistance to Smoothened inhibitors occurs via genetic changes of Smoothened or other downstream Hedgehog components. Here, we overcome these resistance mechanisms by modulating GLI transcription via inhibition of BET bromodomain proteins. We show the BET bromodomain protein, BRD4, regulates GLI transcription downstream of SMO and SUFU and chromatin immunoprecipitation studies reveal BRD4 directly occupies GLI1 and GLI2 promoters, with a substantial decrease in engagement of these sites upon treatment with JQ1, a small molecule inhibitor targeting BRD4. Globally, genes associated with medulloblastoma-specific GLI1 binding sites are downregulated in response to JQ1 treatment, supporting direct regulation of GLI activity by BRD4. Notably, patient- and GEMM-derived Hedgehog-driven tumors (basal cell carcinoma, medulloblastoma and atypical teratoid/rhabdoid tumor) respond to JQ1 even when harboring genetic lesions rendering them resistant to Smoothened antagonists