Application of wireless sensor networks in precision apiculture

14th International Scientific Conference Engineering For Rural Development -- MAY 20-22, 2015 -- Jelgava, LATVIAWOS:000380531200072Wireless sensor networks are used in different fields. One of the fields, where such sensors can be used is apiculture for honey bee (Apis Mellifera L.) monitoring (for example, temperature and humidity data acquisition). This paper introduces a wireless sensor network system for bee colonies online monitoring. The developed wireless system consists of several wireless measurement nodes which transfer colony data to one main unit, which then sends the received data to the cloud database server. Users can see and analyze data using the developed Web system. To this moment temperature and humidity are monitored using the SHT15 sensor. Real time temperature and humidity monitoring of the bee colonies can provide the beekeeper with actual and timely data and information to help identify various states of the bee colonies. Due to the fact, that these sensor data are transmitted wirelessly, it is also easier for the beekeeper to set up such a system (there is no wiring needed).Latvia Univ Agr, Fac Eng

A SAR Study: Evaluation of Bromo Derivatives of 8-Substituted Quinolines as Novel Anticancer Agents

Okten, Salih/0000-0001-9656-1803WOS: 000414248000009Background: Brominated 8-hydroxy, 8-methoxy, 8-amino quinolines 5, 6, 8, 9 and novel cyano 8-hydroxyquinolines 11, 12 were evaluated in vitro for their anticancer effects on various cell lines. 5,7-Dibromo-5, 7-bromo-6, 7-cyano-11 and 5,7-dicyano-12 8-hydroxyquinolines were shown to have strong antiproliferative activity against various tumor cell lines, including C6 (rat brain tumor), HeLa (human cervix carcinoma), and HT29 (human colon carcinoma) with IC50 values ranged from 6.7 to 25.6 mu g/mL. Methods: A structure activity relationship (SAR) was conducted that quinoline core containing hydroxly group at C-8 positon led to more anti cancer potentials. Results: The results of Lactate Dehydrogenase (LDH) cytotoxic, DNA laddering and inhibition assays indicated that 5, 6, 11 and 12 have high cytotoxic effects and appototic potentials. Conclusion: Furthermore, 5 and 12 have inhibitory effects on relaxation of supercoiled plazmid DNA by supressed the Topoisomerase I enzyme. As a result, 5, 6, 11 and 12 may have promising anticancer drug potential and 5 and 12 may be novel topoisomerase inhibitors.Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [112T394]; Kirikkale University Research FundKirikkale University [2012/122]This study was financially supported by grants from the Scientific and Technological Research Council of Turkey (TUBITAK, Project number: 112T394) and Kirikkale University Research Fund (Project number: 2012/122)

In vitro antiproliferative/cytotoxic activity of 2,3 '-biindole against various cancer cell lines

Erenler, Ramazan/0000-0002-0505-3190; Okten, Salih/0000-0001-9656-1803; Kul Koprulu, Tugba/0000-0001-9451-5715WOS: 0003468472000032,3'-Biindole (2) was synthesized via bromination of indole (1) with molecular bromine and underwent simultaneous dimerization. Antiproliferative and cytotoxic activity of 2 was investigated in vitro on C6 (rat brain tumor), HeLa (human cervix carcinoma), and HT29 (human colon carcinoma) cells lines by using BrdU cell proliferation ELISA and lactate dehydrogenase (LDH) assays. In contrast to 5-fluorouracil (5-FU), 2,3'-biindole (2) significantly inhibited proliferation of HeLa and HT29 cell lines. According to LDH assay, the cytotoxicity of compound 2 was low on HT29 cell lines and high on HeLa and C6 cell lines. Moreover, 2 did not cause any DNA laddering on the DNA of tested cells; therefore, it is suggested that the mechanism of action of this compound may not involve apoptosis. In addition, 2 inhibited relaxation of supercoiled plasmid DNA by topoisomerase activity. Results of the present study indicates that biindole (2) may have promising anticancer and antitopoisomerase potential with an unknown mechanism of action.Kirikkale University Research FundKirikkale University [2012/122]This study was financially supported by a grant from the Kirikkale University Research Fund (2012/122)

In vitro antiproliferative/cytotoxic activity of novel quinoline compound SO-18 against various cancer cell lines

European Biotechnology Congress -- MAY 15-18, 2014 -- Lecce, ITALYOkten, Salih/0000-0001-9656-1803WOS: 000350032000338

Determination of anticancer activities of some quinoline derivatives against C6 tumor cells

Eurobiotech Agriculture Symposium -- APR 12-14, 2012 -- Erciyes Univ, Kayseri, TURKEYOkten, Salih/0000-0001-9656-1803WOS: 000318064700076…European Biotechnol Themat Network Asso

Biological evaluation of some quinoline derivatives with different functional groups as anticancer agents

Okten, Salih/0000-0001-9656-1803; Kul Koprulu, Tugba/0000-0001-9451-5715WOS: 000460550900001PubMed: 30431695Due to a great deal of biological activities, quinoline derivatives have drawn attention for synthesis and biological activities in the search for new anticancer drug development. In this work, a variety of substituted (phenyl, nitro, cyano, N-oxide, and methoxy) quinoline derivatives (3-13) were tested in vitro for their biological activity against cancer cell lines, including rat glioblastoma (C6), human cervical cancer cells (HeLa), and human adenocarcinoma (HT29). 6-Bromo-5-nitroquinoline (4), and 6,8-diphenylquinoline (compound 13) showed the greatest antiproliferative activity as compared with the reference drug, 5-fluorouracil (5-FU), while the other compounds showed low antiproliferative activity. 6-Bromo-5-nitroquinoline (4) possesses lower cytotoxic activity than 5-FU in HT29 cell line. Due to its the apoptotic activity 6-Bromo-5-nitroquinoline (4) has the potential to cause cancer cell death.Turkiye Bilimsel ve Teknolojik Arastirma KurumuTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [112T394]; Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu, Grant/Award Number: 112T394; Scientific and Technological Research Council of Turke

Parasitism of immature stages of Haemaphysalis sulcata (Acari: Ixodidae) on some reptiles in Turkey

Reptiles may contribute to maintaining tick populations by feeding larvae, nymphs, and adults. The life cycles and tick-host associations of many Turkish ticks are still poorly known, and only 3 ixodid tick species have been reported on 7 reptile species in Turkey. In this study, we performed a tick survey on reptiles in the Southeastern Anatolia Region of Turkey. In 2005, 57 reptiles (52 lizards and 5 snakes) comprising 10 species from 5 families were captured and examined for tick infestation. A total of 427 ticks was collected. The majority of ticks found on lizards was the immature stages of Haemaphysalis sulcata, 420 larvae and 4 nymphs. The only adult ticks recorded on the agamid lizard, Laudakia stellio, were Hyalomma aegyptium (1♂, 2 ♀). The highest tick infestation rate was recorded on specimens of Timon princeps. This study is the first detailed investigation on ticks infesting reptiles in Turkey. To the best of our knowledge, these tick-host associations have never been documented in the literature. © 2013 American Society of Parasitologists