438 research outputs found

    Effectiveness of an Interactive Application to Assist Learning: A Test Case

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    Advances in computer technologies have made it possible to develop computer-aided learning tools for enhanced learning. Today, most researchers in the field of educational technology seem to be preoccupied with either the development of Artificial Intelligence applications or the representation of various learning theories such as constructivism by a computer program. The enthusiasm to develop technologically advanced learning tools resulted in technologies with limited application. The need to develop simple computer-based tools to assist instruction and demonstrate its effectiveness to enhance learning is paramount. Moreover, those tools need to be designed and integrated into a pedagogical framework. As a result, the instructor transforms into a content facilitator with altered needs. This paper presents the design and use of an interactive computer-aided learning tool for enhanced learning. Two participant groups were randomly selected. One group was allowed to use the interactive computer-aided tool prior to a test, while the second group was not. Performance of the groups was compared. Results revealed a higher mean test score for group one. The impact of the tool on test scores was found to be significant. The findings have direct implications on the design, development, testing and implementation of interactive computer-aided learning tools and on today\u27s transforming roles of educators and learners

    Preparation and Loading with Rifampicin of Sub-50 nm Poly(ethyl cyanoacrylate) Nanoparticles by Semicontinuous Heterophase Polymerization

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    We report the preparation of poly(ethyl cyanoacrylate) (PECA) nanoparticles by semicontinuous heterophase polymerization carried out at monomer starved conditions at three monomer addition rates. Particles in the nanometer range were obtained, the size of which diminishes with decreasing monomer addition rate as shown by the fact that particles with mean diameters of ca. 42 and 30 nm were obtained at the faster and intermediate dosing rates, respectively, whereas two populations of particles, one of 15.5 and the other of 36 nm in mean diameters, were produced at the slower dosing rate. The obtained molecular weights were from 2,200 to 3,500 g/mol, depending on the addition rate, which are typical of the anionic polymerizations of cyanoacrylates in aqueous dispersions at low pHs. The rifampicin (RIF) loading into the nanoparticles was successful since the entire drug added was incorporated. The drug release study carried out at pH of 7.2 indicated a faster release from the free RIF at intermediate and larger release times as expected since, in the nanoparticles, first the drug has to diffuse through the nanoparticle structure. The comparison of several drug release models indicates that the RIF release from PECA nanoparticles follows that of Higuchi

    Embodied GHG emissions of buildings – The hidden challenge for effective climate change mitigation

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    Buildings are major sources of greenhouse gas (GHG) emissions and contributors to the climate crisis. To meet climate-change mitigation needs, one must go beyond operational energy consumption and related GHG emissions of buildings and address their full life cycle. This study investigates the global trends of GHG emissions arising across the life cycle of buildings by systematically compiling and analysing more than 650 life cycle assessment (LCA) case studies. The results, presented for different energy performance classes based on a final sample of 238 cases, show a clear reduction trend in life cycle GHG emissions due to improved operational energy performance. However, the analysis reveals an increase in relative and absolute contributions of so‐called ‘embodied’ GHG emissions, i.e., emissions arising from manufacturing and processing of building materials. While the average share of embodied GHG emissions from buildings following current energy performance regulations is approximately 20–25% of life cycle GHG emissions, this figure escalates to 45–50% for highly energy-efficient buildings and surpasses 90% in extreme cases. Furthermore, this study analyses GHG emissions at time of occurrence, highlighting the ‘carbon spike’ from building production. Relating the results to existing benchmarks for buildings’ GHG emissions in the Swiss SIA energy efficiency path shows that most cases exceed the target of 11.0 kgCO2^{2}eq/m2^{2}a. Considering global GHG reduction targets, these results emphasize the urgent need to reduce GHG emissions of buildings by optimizing both operational and embodied impacts. The analysis further confirmed a need for improving transparency and comparability of LCA studies

    Embodied GHG emissions of buildings - Critical reflection of benchmark comparison and in-depth analysis of drivers

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    In the face of the unfolding climate crisis, the role and importance of reducing Greenhouse gas (GHG) emissions from the building sector is increasing. This study investigates the global trends of GHG emissions occurring across the life cycle of buildings by systematically compiling life cycle assessment (LCA) studies and analysing more than 650 building cases. Based on the data extracted from these LCA studies, the influence of features related to LCA methodology and building design is analysed. Results show that embodied GHG emissions, which mainly arise from manufacturing and processing of building materials, are dominating life cycle emissions of new, advanced buildings. Analysis of GHG emissions at the time of occurrence, shows the upfront \u27carbon spike\u27 and emphasises the need to address and reduce the GHG \u27investment\u27 for new buildings. Comparing the results with existing life cycle-related benchmarks, we find only a small number of cases meeting the benchmark. Critically reflecting on the benchmark comparison, an in-depth analysis reveals different reasons for cases achieving the benchmark. While one would expect that different building design strategies and material choices lead to high or low embodied GHG emissions, the results mainly correlate with decisions related to LCA methodology, i.e. the scope of the assessments. The results emphasize the strong need for transparency in the reporting of LCA studies as well as need for consistency when applying environmental benchmarks. Furthermore, the paper opens up the discussion on the potential of utilizing big data and machine learning for analysis and prediction of environmental performance of buildings

    Randomized Trials of Retosiban Versus Placebo or Atosiban in Spontaneous Preterm Labor.

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    OBJECTIVE:  The aim of this study is to assess the efficacy and safety of retosiban in spontaneous preterm labor (sPTL). STUDY DESIGN:  Two multicenter, randomized, and double-blind trials compared retosiban with placebo and retosiban with atosiban in women with a singleton pregnancy and intact membranes in sPTL at 24 to 336/7 weeks' gestation. Coprimary endpoints in the placebo-controlled trial were time to delivery (TTD) or treatment failure (whichever occurred first) and neonatal composite morbidity and mortality. The primary endpoint of the atosiban comparator trial was TTD. RESULTS:  The trials were terminated early because of slow recruitment. The placebo-controlled trial enrolled 23 participants (February 2016-July 2017; 2.6% of target);the atosiban-comparator trial enrolled 97 (March 2015-August 2017; 29% of target). Baseline participant characteristics were similar between treatments. In the placebo-controlled trial, mean gestational ages at randomization were 30.8 (retosiban, n = 10) and 30.5 weeks (placebo, n = 13), and mean times to delivery/treatment failure were 18.9 days (retosiban) and 11.1 days (placebo). Two and four neonates in the retosiban and placebo groups, respectively, had ≥1 component of the neonatal composite endpoint. In the atosiban-comparator trial, mean gestational age at randomization was 31.5 weeks (for both retosiban, n = 47, and atosiban, n = 50), and adjusted mean TTDs were 32.51 days (retosiban) and 33.71 days (atosiban; p > 0.05). Adverse events were no more common with retosiban than placebo or atosiban. CONCLUSION:  Despite considerable efforts to conduct two adequate and well-controlled studies in patients with sPTL, both studies were unable to recruit effectively and consequently terminated prematurely. Key factors negatively affecting participation were patient and physician resistance to use of a placebo comparator, lack of investigator consensus on diagnostic criteria and acceptance of protocol procedures, and ethics committee decisions. Meaningful cooperation between pharmaceutical companies, regulatory authorities, and the obstetric community is essential for future development of drugs to treat sPTL

    Effect of pH and Monomer Dosing Rate in the Anionic Polymerization of Ethyl Cyanoacrylate in Semicontinuous Operation

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    Nanoparticles of poly(ethyl cyanoacrylate) with more than 10% solids content were prepared by semicontinuous heterophase polymerization at monomer-starved conditions varying the initial pH in the interval of 1–1.75 and at two monomer dosing rates. Measurements by scanning-transmission electron microscopy allowed us to identify an inverse dependence of particle size on pH. Furthermore, all the polymerizations conducted at the slower monomer dosing rate rendered two particle populations, with the larger one formed from the aggregation of a fraction of the smaller particles. It was believed that the so slow addition of the monomer caused the formation of very small but instable particles, thereby a fraction of which aggregated to reduce the total interface particles-aqueous phase, increasing the latex stability. An increase in the monomer dosing rate led to larger and more stable particles in such way that only one population of nanoparticles with around 40 nm in average diameter was obtained
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