Termination of psychotherapy: The journey of ten psychoanalytic and psychodynamic therapists

Objectives: Literature on termination originates mainly from clinical and theoretical accounts as well as practitioners' autobiographical reports. There is, however, a paucity of psychological research on termination, and studies of therapists' experiences are particularly rare. The purpose of this study is to examine the process of termination of therapy based on therapists' narratives of experiences of endings with patients. Design: Grounded Theory methodology has been applied in this study in order to conceptualise the process of termination from the therapist’s perspective. Methods: Ten psychoanalytic and psychodynamic therapists were interviewed for this study. Results: Grounded Theory analysis of the data revealed five central categories: therapist as a person, therapist's awareness of termination, development of therapeutic relationship, working through termination, and the aftermath (post-termination phase). Conclusions: The results offer a Grounded Theory model of the therapist's journey through termination of therapy with patients. Subcategories and their relationships will be explored. Implications for clinical practice, limitations and suggestions for further research will be discussed

Forecasting real housing price growth in the Eighth District states

The authors consider forecasting real housing price growth for the individual states of the Federal Reserve's Eighth District. They first analyze the forecasting ability of a large number of potential predictors of state real housing price growth using an autoregressive distributed lag (ARDL) model framework. A number of variables, including the state housing price-to-income ratio, state unemployment rate, and national inflation rate, appear to provide information that is useful for forecasting real housing price growth in many Eighth District states. Given that it is typically difficult to determine a priori the particular variable or small set of variables that are the most relevant for forecasting real housing price growth for a given state and time period, the authors also consider various methods for combining the individual ARDL model forecasts. They find that combination forecasts are quite helpful in generating accurate forecasts of real housing price growth in the individual Eighth District states.Housing - Prices ; Federal Reserve District, 8th

Hubble Space Telescope Wide Field Camera 3 Identifies an rpr_p = 1 Kpc Dual Active Galactic Nucleus in the Minor Galaxy Merger SDSS J0924+0510 at z = 0.1495

Kiloparsec-scale dual active galactic nuclei (AGNs) are active supermassive black hole pairs co-rotating in galaxies with separations of less than a few kpc. Expected to be a generic outcome of hierarchical galaxy formation, their frequency and demographics remain uncertain. We have carried out an imaging survey with the Hubble Space Telescope (HST) Wide Field Camera 3 (WFC3) of AGNs with double-peaked narrow [O III] emission lines. HST/WFC3 offers high image quality in the near-infrared (NIR) to resolve the two stellar nuclei, and in the optical to resolve [O III] from ionized gas in the narrow-line regions. This combination has proven to be key in sorting out alternative scenarios. With HST/WFC3 we are able to explore a new population of close dual AGNs at more advanced merger stages than can be probed from the ground. Here we show that the AGN SDSS J0924+0510, which had previously shown two stellar bulges, contains two spatially distinct [O III] regions consistent with a dual AGN. While we cannot completely exclude cross-ionization from a single central engine, the nearly equal ratios of [O III] strongly suggest a dual AGN with a projected angular separation of 0."4, corresponding to a projected physical separation of $r_p$ = 1 kpc at redshift z = 0.1495. This serves as a proof of principle for combining high-resolution NIR and optical imaging to identify close dual AGNs. Our result suggests that studies based on low-resolution and/or low-sensitivity observations may miss close dual AGNs and thereby may underestimate their occurrence rate on $\lesssim$ kpc scales.Comment: 11 pages, 8 figures; ApJ in pres

Neomycin resistance as a dominant selectable marker for selection and isolation of vaccinia virus recombinants

The antibiotic G418 was shown to be an effective inhibitor of vaccinia virus replication when an appropriate concentration of it was added to cell monolayers 48 h before infection. Genetic engineering techniques were used in concert with DNA transfection protocols to construct vaccinia virus recombinants containing the neomycin resistance gene (neo) from transposon Tn5. These recombinants contained the neo gene linked in either the correct or incorrect orientation relative to the vaccinia virus 7.5-kilodalton gene promoter which is expressed constitutively throughout the course of infection. The vaccinia virus recombinant containing the chimeric neo gene in the proper orientation was able to grow and form plaques in the presence of G418, whereas both the wild-type and the recombinant virus with the neo gene in the opposite polarity were inhibited by more than 98%. The effect of G418 on virus growth may be mediated at least in part by selective inhibition of the synthesis of a subset of late viral proteins. These results are discussed with reference to using this system, the conferral of resistance to G418 with neo as a positive selectable marker, to facilitate constructing vaccinia virus recombinants which contain foreign genes of interest

Expression of Sindbis virus structural proteins via recombinant vaccinia virus: synthesis, processing, and incorporation into mature Sindbis virions

We have obtained a vaccinia virus recombinant which contains a complete cDNA copy of the 26S RNA of Sindbis virus within the thymidine kinase gene of the vaccinia virus genome. This recombinant constitutively transcribed the Sindbis sequences throughout the infectious cycle, reflecting the dual early-late vaccinia promoter used in this construction. The Sindbis-derived transcripts were translationally active, giving rise to both precursor and mature structural proteins of Sindbis virus, including the capsid protein (C), the precursor of glycoprotein E2 (PE2), and the two mature envelope glycoproteins (E1 and E2). These are the same products translated from the 26S mRNA during Sindbis infection, and thus these proteins were apparently cleaved, glycosylated, and transported in a manner analogous to that seen during authentic Sindbis infections. By using epitope-specific antibodies, it was possible to demonstrate that recombinant-derived proteins were incorporated into Sindbis virions during coinfections with monoclonal antibody-resistant Sindbis variants. These results suggest that all the information necessary to specify the proper biogenesis of Sindbis virus structural proteins resides within the 26S sequences and that vaccinia may provide an appropriate system for using DNA molecular genetic manipulations to unravel a variety of questions pertinent to RNA virus replication

Juvenile rank acquisition is associated with fitness independent of adult rank

Social rank is a significant determinant of fitness in a variety of species. The importance of social rank suggests that the process by which juveniles come to establish their position in the social hierarchy is a critical component of development. Here, we use the highly predictable process of rank acquisition in spotted hyenas to study the consequences of variation in rank acquisition in early life. In spotted hyenas, rank is ‘inherited’ through a learning process called ‘maternal rank inheritance.’ This pattern is very consistent: approximately 80% of juveniles acquire the exact rank expected under the rules of maternal rank inheritance. The predictable nature of rank acquisition in these societies allows the process of rank acquisition to be studied independently from the ultimate rank that each juvenile attains. In this study, we use Elo-deviance scores, a novel application of the Elo-rating method, to calculate each juvenile’s deviation from the expected pattern of maternal rank inheritance during development. Despite variability in rank acquisition among juveniles, most of these juveniles come to attain the exact rank expected of them according to the rules of maternal rank inheritance. Nevertheless, we find that transient variation in rank acquisition in early life is associated with long-term fitness consequences for these individuals: juveniles ‘underperforming’ their expected ranks show reduced survival and lower lifetime reproductive success than better-performing peers, and this relationship is independent of both maternal rank and rank achieved in adulthood. We also find that multiple sources of early life adversity have cumulative, but not compounding, effects on fitness. Future work is needed to determine if variation in rank acquisition directly affects fitness, or if some other variable, such as maternal investment or juvenile condition, causes variation in both of these outcomes. (Includes Supplemental Materials and Reviewers\u27 Comments.