Non-Abelian Vortices on Cylinder -- Duality between vortices and walls

We investigate vortices on a cylinder in supersymmetric non-Abelian gauge theory with hypermultiplets in the fundamental representation. We identify moduli space of periodic vortices and find that a pair of wall-like objects appears as the vortex moduli is varied. Usual domain walls also can be obtained from the single vortex on the cylinder by introducing a twisted boundary condition. We can understand these phenomena as a T-duality among D-brane configurations in type II superstring theories. Using this T-duality picture, we find a one-to-one correspondence between the moduli space of non-Abelian vortices and that of kinky D-brane configurations for domain walls.Comment: 33 pages, 17 figures, v2: references added, typos corrected, the final version published in PR

The geodesic approximation for lump dynamics and coercivity of the Hessian for harmonic maps

The most fruitful approach to studying low energy soliton dynamics in field theories of Bogomol'nyi type is the geodesic approximation of Manton. In the case of vortices and monopoles, Stuart has obtained rigorous estimates of the errors in this approximation, and hence proved that it is valid in the low speed regime. His method employs energy estimates which rely on a key coercivity property of the Hessian of the energy functional of the theory under consideration. In this paper we prove an analogous coercivity property for the Hessian of the energy functional of a general sigma model with compact K\"ahler domain and target. We go on to prove a continuity property for our result, and show that, for the CP^1 model on S^2, the Hessian fails to be globally coercive in the degree 1 sector. We present numerical evidence which suggests that the Hessian is globally coercive in a certain equivariance class of the degree n sector for n>1. We also prove that, within the geodesic approximation, a single CP^1 lump moving on S^2 does not generically travel on a great circle.Comment: 29 pages, 1 figure; typos corrected, references added, expanded discussion of the main function spac

Management of diarrhea in patients with HER2-positive breast cancer treated with neratinib: A case series and summary of the literature

INTRODUCTION: Neratinib and neratinib-based combinations have demonstrated efficacy for treatment of human epidermal growth factor receptor 2-positive (HER2+) early-stage and metastatic breast cancers. However, diarrhea has been reported as a common adverse event leading to neratinib discontinuation. Results from the CONTROL trial suggest that proactive diarrhea management with antidiarrheal prophylaxis or dose escalation of neratinib from a lower starting dose to the full FDA-approved dose of 240 mg/day can reduce the incidence, duration, and severity of neratinib-associated diarrhea in patients with early-stage breast cancer. Dose escalation has been included in the FDA-approved label for both early-stage and metastatic HER2+ breast cancer since June 2021. CASE SERIES: This series of five cases details real-world clinical implementation of strategies for management of neratinib-induced diarrhea in patients with early-stage and metastatic HER2+ breast cancer, including a patient with a pre-existing gastrointestinal disorder. MANAGEMENT AND OUTCOME: In four of five cases, diarrhea was managed with neratinib dose escalation, and antidiarrheal prophylaxis with loperamide plus colestipol was used in the remaining case. Management of diarrhea allowed all patients to remain on therapy. DISCUSSION: This case series shows that neratinib-associated diarrhea can be managed effectively with neratinib dose escalation from a lower initial starting dose and/or prophylactic antidiarrheal medications in a real-world clinical setting. The findings highlight the importance of patient-provider communication in proactive management of adverse events. Widespread implementation of the strategies described here may improve adherence and thereby clinical outcomes for patients with HER2+ breast cancer treated with neratinib

The acquisition of Sign Language: The impact of phonetic complexity on phonology

Research into the effect of phonetic complexity on phonological acquisition has a long history in spoken languages. This paper considers the effect of phonetics on phonological development in a signed language. We report on an experiment in which nonword-repetition methodology was adapted so as to examine in a systematic way how phonetic complexity in two phonological parameters of signed languages — handshape and movement — affects the perception and articulation of signs. Ninety-one Deaf children aged 3–11 acquiring British Sign Language (BSL) and 46 hearing nonsigners aged 6–11 repeated a set of 40 nonsense signs. For Deaf children, repetition accuracy improved with age, correlated with wider BSL abilities, and was lowest for signs that were phonetically complex. Repetition accuracy was correlated with fine motor skills for the youngest children. Despite their lower repetition accuracy, the hearing group were similarly affected by phonetic complexity, suggesting that common visual and motoric factors are at play when processing linguistic information in the visuo-gestural modality

Resolving a gender and language problem in women’s leadership:consultancy research in workplace discourse

This article considers the contribution that consultancy research might make to resolving communication problems that women have identified in their leadership practices. Within the intersecting fields of gender and language and workplace discourse, consultancy research-that is, practitioner-commissioned research to resolve work-related, communication problems-is still uncommon. This article presents a study of Monika, a senior leader in an engineering company, who commissioned me to find out why she was experiencing communication problems with her teams. By using interactional sociolinguistic analysis, I was able to show Monika how her authority was being resisted on gendered, linguistic grounds. In making the case for more consultancy research, I discuss how we might use insights from discourse analysis to offer guidance to practitioners seeking our help

CHARACTERIZING THE YUCCA MOUNTAIN SITE FOR DEVELOPING SEISMIC DESIGN GROUND MOTIONS

Yucca Mountain, Nevada is the designated site for the first long-term geologic repository to safely dispose spent nuclear fuel and high-level nuclear waste in the U.S. Yucca Mountain consists of stacked layers of welded and non-welded volcanic tuffs. Site characterization studies are being performed to assess its future performance as a permanent geologic repository. These studies include the characterization of the shear-wave velocity (Vs) structure of the repository block and the surface facilities area. The Vs data are an input in the calculations of ground motions for the preclosure seismic design and for postclosure performance assessment and therefore their accurate estimation is needed. Three techniques have been employed: 24 downhole surveys, 15 suspension seismic logging surveys and 95 spectral-analysis-of-surface-waves (SASW) surveys have been performed to date at the site. The three data sets were compared with one another and with Vs profiles developed from vertical seismic profiling data collected by the Lawrence Berkeley National Laboratory and with Vs profiles developed independently by the University of Nevada, Reno using the refraction microtremor technique. Based on these data, base case Vs profiles have been developed and used in site response analyses. Since the question of adequate sampling arises in site characterization programs and a correlation between geology and Vs would help address this issue, a possible correlation was evaluated. To assess the influence of different factors on velocity, statistical analyses of the Vs data were performed using the method of multi-factor Analysis of Variance (ANOVA). The results of this analysis suggest that the effect of each of three factors, depth, lithologic unit, and spatial location, on velocity is statistically significant. Furthermore, velocity variation with depth is different at different spatial locations: Preliminary results show that the lithologic unit alone explains about 54% and 42% of the velocity variation in the suspension and downhole data sets, respectively. The three factors together explain about 73% and 81% of the velocity variation in the suspension and downhole data sets, respectively. Development of a relationship, using multiple regression analysis, which may be used as a predictive tool to estimate velocity at a new location, is currently being examined

Phonological Coding during Sentence Reading in Chinese Deaf Readers: An Eye-Tracking Study

Phonological coding plays an important role in reading for hearing students. 3 Experimental findings regarding phonological coding in deaf readers are 4 controversial, and whether deaf readers are able to use phonological coding 5 remains unclear. In the current study we examined whether Chinese deaf students 6 could use phonological coding during sentence reading. Deaf middle school 7 students, chronological age-matched hearing students, and reading ability-8 matched hearing students had their eye movements recorded as they read 9 sentences containing correctly spelled characters, homophones, or unrelated 10 characters. Both hearing groups had shorter total reading times on homophones 11 than they did on unrelated characters. In contrast, no significant difference was 12 found between homophones and unrelated characters for the deaf students. 13 However, when the deaf group was divided into more-skilled and less-skilled 14 readers according to their scores on reading fluency, the homophone advantage 15 noted for the hearing controls was also observed for the more-skilled deaf 16 students

The (In)Authenticity of Simulated Talk: Comparing Role-Played and Actual Interaction and the Implications for Communication Training

This article was published in the journal, Research on Language and Social Interaction [Taylor & Francis (Routledge)] and the definitive version is available at: http://dx.doi.org/10.1080/08351813.2013.780341How authentic is simulated, or role-played, interaction, of the kind produced in communication training contexts? The article addresses this question by comparing actual and role-played police investigative interviews. Both types of interviews were recorded by the police: real ones to fulfill British legal requirements and training ones to maximize the authenticity of the training experience. Interview openings were examined using conversation analysis. Officers must adhere to Police and Criminal Evidence Act (2008) guidelines, turning them into spoken actions. The analyses revealed that while, in gross terms, officers in real and simulated interviews opened interviews by formulating the same actions (e.g., identifying copresent parties), differences were observable in their design and organization. In simulations, actions were more elaborate or exaggerated; that is, they were made interactionally visible and “assessable.” Furthermore, some actions were only present in simulations. Implications for the efficacy of role-play methods for training and assessing communication are discussed