Silicon Needle Transducer

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The Myth of Female Underachievement: A Reexamination of Sex Differences in Academic Underachievement

14 pagesThis paper examines sex differences in academic underachievement among students who graduated from high school in a western city in 1978. According to data gathered from students' cumulative records for the 7th through 12th grades, males are much more likely than females to have total grade averages and grades in English and mathematics that are lower than would be predicted by their scores on standardized tests of ability. Although the highest achieving females often have lower average ability test scores than the highest achieving males, this results not from the underachievement of the brightest females but from the fact that females with a wide range of ability levels receive good grades and only the very brightest males receive high grades. These sex differences in underachievement appear for middle class and working class students, but often are smaller for the working class and in mathematics grades

Academic merit, status variables, and students' grades

9 pagesStudents' grades are important mechanisms for advancement and success in life. Grades are criteria for college admission and academic awards, and they undoubtedly influence the encouragement and advice students receive regarding their future plans. In using grades in these ways it is assumed that they reflect students' actual achievement. This paper examines this assumption by looking at the extent to which ability, social class, and gender, as well as achievement. influence students' grades in school. Earlier work is extended by including both gender and social class in the analysis and by examining influences on students' grades in each year from the 7th- to the 12th-grade and both the total grade average and marks in the subject areas of mathematics and English. The total grade averages were examined because they have most often been the focus of other studies. English and mathematics grades were examined because of the centrality of these disciplines to the school curriculum and because of the association of achievement in these areas with both gender and social class

Gender Roles and Behavior in Social Dilemmas: Are there Sex Differences in Cooperation and in its Justification?

10 pagesData from two experimental social dilemmas-a set of 66 nine-person dilemmas and a set of 64 seven-person dilemmas-were used to examine sex differences in cooperation. Women were only slightly more likely than men to cooperate with others, and variables related to the experimental setting were much more important influences on behavior than sex. Whether or not the women cooperated, they were more likely than men to justify their behavior as being altruistic and principled, to believe that they were more oriented toward harmonious group relations, and to be less nervous and upset at the end of the experiment. It is suggested that those who speculate on sex differences in cooperation may have overstated these differences and that the relationship between self-schema and behavior may vary depending on the extent to which the attributes studied relate to gender identity

Impact of facial conformation on canine health: Brachycephalic Obstructive Airway Syndrome

The domestic dog may be the most morphologically diverse terrestrial mammalian species known to man; pedigree dogs are artificially selected for extreme aesthetics dictated by formal Breed Standards, and breed-related disorders linked to conformation are ubiquitous and diverse. Brachycephaly–foreshortening of the facial skeleton–is a discrete mutation that has been selected for in many popular dog breeds e.g. the Bulldog, Pug, and French Bulldog. A chronic, debilitating respiratory syndrome, whereby soft tissue blocks the airways, predominantly affects dogs with this conformation, and thus is labelled Brachycephalic Obstructive Airway Syndrome (BOAS). Despite the name of the syndrome, scientific evidence quantitatively linking brachycephaly with BOAS is lacking, but it could aid efforts to select for healthier conformations. Here we show, in (1) an exploratory study of 700 dogs of diverse breeds and conformations, and (2) a confirmatory study of 154 brachycephalic dogs, that BOAS risk increases sharply in a non-linear manner as relative muzzle length shortens. BOAS only occurred in dogs whose muzzles comprised less than half their cranial lengths. Thicker neck girths also increased BOAS risk in both populations: a risk factor for human sleep apnoea and not previously realised in dogs; and obesity was found to further increase BOAS risk. This study provides evidence that breeding for brachycephaly leads to an increased risk of BOAS in dogs, with risk increasing as the morphology becomes more exaggerated. As such, dog breeders and buyers should be aware of this risk when selecting dogs, and breeding organisations should actively discourage exaggeration of this high-risk conformation in breed standards and the show ring

Cellular Metabolomics Profiles Associated With Drug Chemosensitivity in AML

BackgroundAcute myeloid leukemia (AML) is a hematological malignancy with a dismal prognosis. For over four decades, AML has primarily been treated by cytarabine combined with an anthracycline. Although a significant proportion of patients achieve remission with this regimen, roughly 40% of children and 70% of adults relapse. Over 90% of patients with resistant or relapsed AML die within 3 years. Thus, relapsed and resistant disease following treatment with standard therapy are the most common clinical failures that occur in treating this disease. In this study, we evaluated the relationship between AML cell line global metabolomes and variation in chemosensitivity.MethodsWe performed global metabolomics on seven AML cell lines with varying chemosensitivity to cytarabine and the anthracycline doxorubicin (MV4.11, KG-1, HL-60, Kasumi-1, AML-193, ME1, THP-1) using ultra-high performance liquid chromatography – mass spectrometry (UHPLC-MS). Univariate and multivariate analyses were performed on the metabolite peak intensity values from UHPLC-MS using MetaboAnalyst to identify cellular metabolites associated with drug chemosensitivity.ResultsA total of 1,624 metabolic features were detected across the leukemic cell lines. Of these, 187 were annotated to known metabolites. With respect to doxorubicin, we observed significantly greater abundance of a carboxylic acid (1-aminocyclopropane-1-carboxylate) and several amino acids in resistant cell lines. Pathway analysis found enrichment of several amino acid biosynthesis and metabolic pathways. For cytarabine resistance, nine annotated metabolites were significantly different in resistance vs. sensitive cell lines, including D-raffinose, guanosine, inosine, guanine, aldopentose, two xenobiotics (allopurinol and 4-hydroxy-L-phenylglycine) and glucosamine/mannosamine. Pathway analysis associated these metabolites with the purine metabolic pathway.ConclusionOverall, our results demonstrate that metabolomics differences contribute toward drug resistance. In addition, it could potentially identify predictive biomarkers for chemosensitivity to various anti-leukemic drugs. Our results provide opportunity to further explore these metabolites in patient samples for association with clinical response

Is well-being U-shaped over the life cycle?

We present evidence that psychological well-being is U-shaped through life. A difficulty with research on this issue is that there are likely to be omitted cohort effects (earlier generations may have been born in, say, particularly good or bad times). First, using data on 500,000 randomly sampled Americans and West Europeans, the paper designs a test that can control for cohort effects. Holding other factors constant, we show that a typical individual’s happiness reaches its minimum -- on both sides of the Atlantic and for both males and females -- in middle age. Second, evidence is provided for the existence of a similar U-shape through the life-course in East European, Latin American and Asian nations. Third, a U-shape in age is found in separate well-being regression equations in 72 developed and developing nations. Fourth, using measures that are closer to psychiatric scores, we document a comparable well-being curve across the life cycle in two other data sets : (i) in GHQ-N6 mental health levels among a sample of 16,000 Europeans, and (ii) in reported depression and anxiety levels among 1 million U.K. citizens. Fifth, we discuss some apparent exceptions, particularly in developing nations, to the U-shape. Sixth, we note that American male birth-cohorts seem to have become progressively less content with their lives. Our paper’s results are based on regression equations in which other influences, such as demographic variables and income, are held constant