The primary visual system of adult lizards demonstrates that neurogenesis is not obligatorily linked to central nerve regeneration but may be a prerequisite for the restoration of maps in the brain

AbstractFollowing optic nerve crush in the adult lizard Ctenophorus ornatus, most retinal ganglion cells regrow their axons into visual brain centres: however, the regenerated projections lack retinotopic order and the animals are blind via the experimental eye. Here we have used 3H-thymidine autoradiography to demonstrate that cell division is no longer taking place in the retina of normal adult lizards. We conclude that the optic nerve can regenerate in lizard even though cells are no longer being added to the retina, However, continued retinal neurogenesis may be linked to the ability to restore topographic maps

Will we see you again? Population evaluation of Palinurus elephas inside a marine reserve from Capture-Mark-Recapture data

To achieve an effective management of the marine exploited populations it is necessary to understand their dynamics and the processes driving short- and long-term changes. Key population parameters such as survival and movement can be estimated by means of capture-mark-recapture studies, based on the capture, tagging and re-encounter of the individuals at later times. The Cormack-Jolly-Seber model, which assesses the apparent survival i and the recapture rate pi of a population conditional on first capture, was applied to European spiny lobster Palinurus elephas data from the Columbretes islands marine reserve to evaluate the evolution of this population after closure to fishing over. Particularly strong winter conditions were reported for some years during the period of study whcih were reflected as an increase in the estimate of the encounter probability and a decrease in their survival rate. P. elephas showed a relatively high plasticity against short-term environmental effects, with the apparent survival quickly returning to pre-storm levels. Also a slight increase in survival was identified for this protected population over time. These preliminary results are discussed in terms of the factors affecting the dynamics of this population and the implications for the management of this exploited stoc

Temperature dependence of the spin and orbital magnetization density in Sm1−xGdxAl2Sm_{1-x}Gd_{x} Al_{2} around the spin-orbital compensation point

Non-resonant ferromagnetic x-ray diffraction has been used to separate the spin and orbital contribution to the magnetization density of the proposed zero-moment ferromagnet $Sm_{0.982}Gd_{0.018} Al_{2}$. The alignment of the spin and orbital moments relative to the net magnetization shows a sign reversal at 84K, the compensation temperature. Below this temperature the orbital moment is larger than the spin moment, and vice versa above it. This result implies that the compensation mechanism is driven by the different temperature dependencies of the $4f$ spin and orbital moments. Specific heat data indicate that the system remains ferromagnetically ordered throughout

Crystal structure and magnetic modulation in β−Ce2O2FeSe2

We report a combination of X-ray and neutron diffraction studies, Mossbauer spectroscopy and muon spin relaxation (muSR) measurements to probe the structure and magnetic properties of the semiconducting beta-Ce2O2FeSe2 oxychalcogenide. We report a new structural description in space group Pna21 which is consistent with diffraction data and second harmonic generation measurements and reveal an order-disorder transition on one Fe site at TOD ~ 330 K. Susceptibility measurements, Mossbauer and muSR reveal antiferromagnetic ordering below TN = 86 K and more complex short range order above this temperature. 12 K neutron diffraction data reveal a modulated magnetic structure with q = 0.444 bN*

Read-It: A Multi-modal Tangible Interface for Children Who Learn to Read

Multi-modal tabletop applications offer excellent opportunities for enriching the education of young children. Read-It is an example of an interactive game with a multi-modal tangible interface that was designed to combine the advantages of current physical games and computer exercises. It is a novel approach for supporting children who learn to read. The first experimental evaluation has demonstrated that the Read-It approach is indeed promising and meets a priori expectations

Structure of Fat Jets at the Tevatron and Beyond

Boosted resonances is a highly probable and enthusiastic scenario in any process probing the electroweak scale. Such objects when decaying into jets can easily blend with the cornucopia of jets from hard relative light QCD states. We review jet observables and algorithms that can contribute to the identification of highly boosted heavy jets and the possible searches that can make use of such substructure information. We also review previous studies by CDF on boosted jets and its measurements on specific jet shapes.Comment: invited review for a special "Top and flavour physics in the LHC era" issue of The European Physical Journal C, we invite comments regarding contents of the review; v2 added references and institutional preprint number

Bailing Out the Milky Way: Variation in the Properties of Massive Dwarfs Among Galaxy-Sized Systems

Recent kinematical constraints on the internal densities of the Milky Way's dwarf satellites have revealed a discrepancy with the subhalo populations of simulated Galaxy-scale halos in the standard CDM model of hierarchical structure formation. This has been dubbed the "too big to fail" problem, with reference to the improbability of large and invisible companions existing in the Galactic environment. In this paper, we argue that both the Milky Way observations and simulated subhalos are consistent with the predictions of the standard model for structure formation. Specifically, we show that there is significant variation in the properties of subhalos among distinct host halos of fixed mass and suggest that this can reasonably account for the deficit of dense satellites in the Milky Way. We exploit well-tested analytic techniques to predict the properties in a large sample of distinct host halos with a variety of masses spanning the range expected of the Galactic halo. The analytic model produces subhalo populations consistent with both Via Lactea II and Aquarius, and our results suggest that natural variation in subhalo properties suffices to explain the discrepancy between Milky Way satellite kinematics and these numerical simulations. At least ~10% of Milky Way-sized halos host subhalo populations for which there is no "too big to fail" problem, even when the host halo mass is as large as M_host = 10^12.2 h^-1 M_sun. Follow-up studies consisting of high-resolution simulations of a large number of Milky Way-sized hosts are necessary to confirm our predictions. In the absence of such efforts, the "too big to fail" problem does not appear to be a significant challenge to the standard model of hierarchical formation. [abridged]Comment: 12 pages, 3 figures; accepted by JCAP. Replaced with published versio

The use of dexamethasone in women with preterm premature rupture of membranes - A multicentre, double-blind, placebocontrolled, randomised trial

No Abstract

Further analysis of the quantum critical point of Ce1−x_{1-x}Lax_{x}Ru2_{2}Si2_{2}

New data on the spin dynamics and the magnetic order of Ce$_{1-x}$La$_{x}$Ru$_{2}$Si$_{2}$ are presented. The importance of the Kondo effect at the quantum critical point of this system is emphasized from the behaviour of the relaxation rate at high temperature and from the variation of the ordered moment with respect to the one of the N\'eel temperature for various $x$.Comment: Contribution for the Festschrift on the occasion of Hilbert von Loehneysen 60 th birthday. To be published as a special issue in the Journal of Low Temperature Physic

A community jury study exploring the public acceptability of using risk stratification to determine eligibility for cancer screening

Introduction Using risk stratification to determine eligibility for cancer screening is likely to improve the efficiency of screening programmes by targeting resources towards those most likely to benefit. We aimed to explore the implications of this approach from a societal perspective by understanding public views on the most acceptable stratification strategies. Methods We conducted three online community juries with 9 or 10 participants in each. Participants were purposefully sampled by age (40–79 years), sex, ethnicity, social grade and English region. On the first day, participants were informed of the potential benefits and harms of cancer screening and the implications of different ways of introducing stratification using scenarios based on phenotypic and genetic risk scores. On the second day, participants deliberated to reach a verdict on the research question, ‘Which approach(es) to inviting people to screening are acceptable, and under what circumstances?’ Deliberations and feedback were recorded and analysed using thematic analysis. Results Across the juries, the principle of risk stratification was generally considered to be an acceptable approach for determining eligibility for screening. Disregarding increasing capacity, the participants considered it to enable efficient resource allocation to high-risk individuals and could see how it might help to save lives. However, there were concerns regarding fair implementation, particularly how the risk assessment would be performed at scale and how people at low risk would be managed. Some favoured using the most accurate risk prediction model whereas others thought that certain risk factors should be prioritized (particularly factors considered as non-modifiable and relatively stable, such as genetics and family history). Transparently justifying the programme and public education about cancer risk emerged as important contributors to acceptability. Conclusion Using risk stratification to determine eligibility for cancer screening was acceptable to informed members of the public, particularly if it included risk factors they considered fair and when communicated transparently. Patient or Public Contribution Two patient and public involvement representatives were involved throughout this study. They were not involved in synthesizing the results but contributed to producing study materials, co-facilitated the community juries and commented on the interpretation of the findings and final report