1,899 research outputs found
The Proper Extent of Liability a Condominium Unit Owner Should Have for Injuries Caused by a Limited Common Element
The Proper Extent of Liability a Condominium Unit Owner Should Have for Injuries Caused by a Limited Common Element
Soluble Guanylate Cyclase Generation of cGMP Regulates Migration of MGE Neurons
Here we have provided evidence that nitric oxide-cyclic GMP (NO-cGMP) signaling regulates neurite length and migration of immature neurons derived from the medial ganglionic eminence (MGE). Dlx1/2(-/-) and Lhx6(-/-) mouse mutants, which exhibit MGE interneuron migration defects, have reduced expression of the gene encoding the alpha subunit of a soluble guanylate cyclase (Gucy1A3). Furthermore, Dlx1/2(-/-) mouse mutants have reduced expression of NO synthase 1 (NOS1). Gucy1A3(-/-) mice have a transient reduction in cortical interneuron number. Pharmacological inhibition of soluble guanylate cyclase and NOS activity rapidly induces neurite retraction of MGE cells in vitro and in slice culture and robustly inhibits cell migration from the MGE and caudal ganglionic eminence. We provide evidence that these cellular phenotypes are mediated by activation of the Rho signaling pathway and inhibition of myosin light chain phosphatase activity
The OPERA magnetic spectrometer
The OPERA neutrino oscillation experiment foresees the construction of two
magnetized iron spectrometers located after the lead-nuclear emulsion targets.
The magnet is made up of two vertical walls of rectangular cross section
connected by return yokes. The particle trajectories are measured by high
precision drift tubes located before and after the arms of the magnet.
Moreover, the magnet steel is instrumented with Resistive Plate Chambers that
ease pattern recognition and allow a calorimetric measurement of the hadronic
showers. In this paper we review the construction of the spectrometers. In
particular, we describe the results obtained from the magnet and RPC prototypes
and the installation of the final apparatus at the Gran Sasso laboratories. We
discuss the mechanical and magnetic properties of the steel and the techniques
employed to calibrate the field in the bulk of the magnet. Moreover, results of
the tests and issues concerning the mass production of the Resistive Plate
Chambers are reported. Finally, the expected physics performance of the
detector is described; estimates rely on numerical simulations and the outcome
of the tests described above.Comment: 6 pages, 10 figures, presented at the 2003 IEEE-NSS conference,
Portland, OR, USA, October 20-24, 200
âComing back Homeâ . Il Modello Virtuale della Statua Romana di Asclepio del Museo di Siracusa (Italia)
The colossal torso of the god Asclepius, kept into the Castello Maniace during the Spanish domination of Sicily, is now one of the most significant examples of roman statuary in the Syracuse Museum. The recent restoration of the Castello Maniace has been celebrated in 2008 with an exhibition of archaeological finds obtained in the various excavations of the castle. The statue of Asclepius, which had for centuries been a part of the architecture there, should have been the most significant piece on display. However, its large size and frailty made such a temporary move inadvisable, and it was decided that a plaster cast should be made and exhibited instead. A team of archaeologists and information technicians from the Archeomatica Project of Catania University were able to contribute to this task by creating a 3D model of the statue through the use of laser scanning techniques
Rho primes in analyzing e+e- annihilation, MARK III, LASS and ARGUS data
The results of an analysis are presented of some recent data on the reactions
, with the
subtracted events, , , , , the decays
,
, upon taking into account both the strong energy
dependence of the partial widths on energy and the previously neglected mixing
of the type resonances. The above effects are shown to exert an
essential influence on the specific values of masses and coupling constants of
heavy resonances and hence are necessary to be accounted for in establishing
their true nature.Comment: 20 pages, ReVTeX, 9 Postscript figures As compared to hep-ph/9607398,
new material concerning the analysis of the ARGUS data on the tau decays into
four pion hadronic states is adde
Integrated three-dimensional models for noninvasive monitoring and valorization of the Morgantina silver treasure (Sicily)
The Morgantina silver treasure belonging to the Archaeological Museum of Aidone (Sicily) was
involved in a three-dimensional (3-D) survey and diagnostics campaign for monitoring the collection over
time in anticipation of their temporary transfer to the Metropolitan Museum of Art in New York for a period
of 4 years. Using a multidisciplinary approach, a scientific and methodological protocol based on noninvasive
techniques to achieve a complete and integrated knowledge of the precious items and their conservation state,
as well as to increase their valorization, has been developed. All acquired data, i.e., 3-D models, ultraviolet
fluorescence, x-ray images, and chemical information, will be made available, in an integrated way, within a
web-oriented platform, which will present an in-progress tool to deepen existing archaeological knowledge
and production technologies and to obtain referenced information of the conservation state before and after
moving of the collection from its exposure site
Electromagnetic form factors in the J/\psi mass region: The case in favor of additional resonances
Using the results of our recent analysis of e^+e^- annihilation, we plot the
curves for the diagonal and transition form factors of light hadrons in the
time-like region up to the production threshold of an open charm quantum
number. The comparison with existing data on the decays of J/\psi into such
hadrons shows that some new resonance structures may be present in the mass
range between 2 GeVand the J/\psi mass. Searching them may help in a better
understanding of the mass spectrum in both the simple and a more sophisticated
quark models, and in revealing the details of the three-gluon mechanism of the
OZI rule breaking in K\bar K channel.Comment: Formulas are added, typo is corrected, the text is rearranged.
Replaced to match the version accepted in Phys Rev
Hypoxia promotes the inflammatory response and stemness features in visceral fat stem cells from obese subjects
Low-grade chronic inflammation is a salient feature of obesity and many associated disorders. This condition frequently occurs in central obesity and is connected to alterations of the visceral adipose tissue (AT) microenvironment. Understanding how obesity is related to inflammation may allow the development of therapeutics aimed at improving metabolic parameters in obese patients. To achieve this aim, we compared the features of 2 subpopulations of adipose-derived stem cells (ASC) isolated from both subcutaneous and visceral AT of obese patients with the features of 2 subpopulations of ASC from the same isolation sites of non-obese individuals. In particular, the behavior of ASC of obese vs non-obese subjects during hypoxia, which occurs in obese AT and is an inducer of the inflammatory response, was evaluated. Obesity deeply influenced ASC from visceral AT (obV-ASC); these cells appeared to exhibit clearly distinguishable morphology and ultrastructure as well as reduced proliferation, clonogenicity and expression of stemness, differentiation and inflammation-related genes. These cells also exhibited a deregulated response to hypoxia, which induced strong tissue-specific NF-kB activation and an NF-kB-mediated increase in inflammatory and fibrogenic responses. Moreover, obV-ASC, which showed a less stem-like phenotype, recovered stemness features after hypoxia. Our findings demonstrated the peculiar behavior of obV-ASC, their influence on the obese visceral AT microenvironment and the therapeutic potential of NF-kB inhibitors. These novel findings suggest that the deregulated hyper-responsiveness to hypoxic stimulus of ASC from visceral AT of obese subjects may contribute via paracrine mechanisms to low-grade chronic inflammation, which has been implicated in obesity-related morbidity
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