2,107 research outputs found
PerfWeb: How to Violate Web Privacy with Hardware Performance Events
The browser history reveals highly sensitive information about users, such as
financial status, health conditions, or political views. Private browsing modes
and anonymity networks are consequently important tools to preserve the privacy
not only of regular users but in particular of whistleblowers and dissidents.
Yet, in this work we show how a malicious application can infer opened websites
from Google Chrome in Incognito mode and from Tor Browser by exploiting
hardware performance events (HPEs). In particular, we analyze the browsers'
microarchitectural footprint with the help of advanced Machine Learning
techniques: k-th Nearest Neighbors, Decision Trees, Support Vector Machines,
and in contrast to previous literature also Convolutional Neural Networks. We
profile 40 different websites, 30 of the top Alexa sites and 10 whistleblowing
portals, on two machines featuring an Intel and an ARM processor. By monitoring
retired instructions, cache accesses, and bus cycles for at most 5 seconds, we
manage to classify the selected websites with a success rate of up to 86.3%.
The results show that hardware performance events can clearly undermine the
privacy of web users. We therefore propose mitigation strategies that impede
our attacks and still allow legitimate use of HPEs
Pentoxifylline Plus Prednisolone versus Pentoxifylline Only for Severe Alcoholic Hepatitis: A Randomized Controlled Clinical Trial
Background: Prednisolone and pentoxifylline (PTX) have been shown to be individually useful in severe alcoholic hepatitis with Maddrey discriminant function (MDF) score .32. Previous report suggests that PTX is probably superior to prednisolone alone. However the efficacy of PTX and prednisolone combination over PTX alone in the management of acute alcoholic hepatitis (MDF score ≥32) is yet unrevealed.Aim: The present study was initiated to find out the efficacy of combined pentoxifylline and prednisolone versus PTX alone in acute alcoholic hepatitis in respect of short and intermediate term outcomes.Subjects and Methods: A total of 124 patients with severe alcoholic hepatitis (MDF score ≥32) initially were evaluated. 62 patients who fulfilled the inclusion and exclusion criteria were randomized and divided into 2 groups. Group 1 received PTX only, whereas Group 2 received PTX plus Prednisolone. The total duration of follow-up was 12 months. Studentfs t-test, Chi-square test, the Kaplan-Meier methods were used forstatistical analysis. Results: A total of 60 patients, 30 in each group were available for finalanalysis. In Group-1, 6 patients expired at the end of 1 year (5 within 3 months and another after 3 months). In Group 2, 10 patients expired at the end of 1 year (9 within 3 months and another after 3 months). Though survival probability is higher among Group 1 patients but the difference is not statistically significant.Conclusion: The combination of PTX plus Prednisolone yields no additional benefit in terms of mortality and morbidity from that of PTX monotherapy.Keywords: Alcoholic hepatitis, Maddrey discriminant function score, Pentoxifylline, Prednisolon
RPGR mutation associated with retinitis pigmentosa, impaired hearing, and sinorespiratory infections
Small Hairy Black Holes in Global AdS Spacetime
We study small charged black holes in global AdS spacetime in the presence of
a charged massless minimally coupled scalar field. In a certain parameter range
these black holes suffer from well known superradiant instabilities. We
demonstrate that the end point of the resultant tachyon condensation process is
a hairy black hole which we construct analytically in a perturbative expansion
in the black hole radius. At leading order our solution is a small undeformed
RNAdS black hole immersed into a charged scalar condensate that fills the AdS
`box'. These hairy black hole solutions appear in a two parameter family
labelled by their mass and charge. Their mass is bounded from below by a
function of their charge; at the lower bound a hairy black hole reduces to a
regular horizon free soliton which can also be thought of as a nonlinear Bose
condensate. We compute the microcanonical phase diagram of our system at small
mass, and demonstrate that it exhibits a second order `phase transition'
between the RNAdS black hole and the hairy black hole phases.Comment: 68+1 pages, 18 figures, JHEP format. v2 : small typos corrected and a
reference adde
First insights into the expression of VAX2 in humans and its localization in the adult primate retina
VAX2 is a transcription factor specifically expressed in the ventral region of the prospective neural retina in vertebrates and is required for ventral eye specification. Despite its extensive analysis in vertebrates, the biological role of VAX2 in the human is presently unclear. This study was undertaken to investigate VAX2 in humans aiming to gain new knowledge into its involvement in retinal function. Here, we report VAX2 gene expression and protein localization in cultured cells and adult retina. RT-PCR experiments indicated that VAX2 is enriched in neuronal tissues. Moreover, we identified a novel isoform most abundantly expressed in the retina. We termed the known transcript (NM_012476) isoform-1, and the newly identified transcript as isoform-2. Analysis of protein localization in cultured cells revealed that isoform-1 localizes to the nucleus and isoform-2 is widely expressed within the cell; partial co-localization of isoform-2 and actin filaments was also observed. In nonhuman primate retina VAX2 was seen either in the nuclear or in the cytoplasmic compartment depending on the retinal cell type. In addition, a noteworthy enrichment of the signal was observed in the outer segment of cone photoreceptors.
Overall, this study provides the first insights into the expression of VAX2 in humans and its localization in the adult primate retina. Moreover, preliminary characterization of alternative variants suggests an involvement of VAX2 in multiple cellular pathways. Our findings raise the interesting possibility for further investigation of VAX2 in the retina in health and disease
Shock waves in strongly coupled plasmas
Shock waves are supersonic disturbances propagating in a fluid and giving
rise to dissipation and drag. Weak shocks, i.e., those of small amplitude, can
be well described within the hydrodynamic approximation. On the other hand,
strong shocks are discontinuous within hydrodynamics and therefore probe the
microscopics of the theory. In this paper we consider the case of the strongly
coupled N=4 plasma whose microscopic description, applicable for scales smaller
than the inverse temperature, is given in terms of gravity in an asymptotically
space. In the gravity approximation, weak and strong shocks should be
described by smooth metrics with no discontinuities. For weak shocks we find
the dual metric in a derivative expansion and for strong shocks we use
linearized gravity to find the exponential tail that determines the width of
the shock. In particular we find that, when the velocity of the fluid relative
to the shock approaches the speed of light the penetration depth
scales as . We compare the results with second
order hydrodynamics and the Israel-Stewart approximation. Although they all
agree in the hydrodynamic regime of weak shocks, we show that there is not even
qualitative agreement for strong shocks. For the gravity side, the existence of
shock waves implies that there are disturbances of constant shape propagating
on the horizon of the dual black holes.Comment: 47 pages, 8 figures; v2:typos corrected, references adde
Quantum critical lines in holographic phases with (un)broken symmetry
All possible scaling IR asymptotics in homogeneous, translation invariant
holographic phases preserving or breaking a U(1) symmetry in the IR are
classified. Scale invariant geometries where the scalar extremizes its
effective potential are distinguished from hyperscaling violating geometries
where the scalar runs logarithmically. It is shown that the general critical
saddle-point solutions are characterized by three critical exponents (). Both exact solutions as well as leading behaviors are exhibited.
Using them, neutral or charged geometries realizing both fractionalized or
cohesive phases are found. The generic global IR picture emerging is that of
quantum critical lines, separated by quantum critical points which correspond
to the scale invariant solutions with a constant scalar.Comment: v3: 32+29 pages, 2 figures. Matches version published in JHEP.
Important addition of an exponent characterizing the IR scaling of the
electric potentia
Design, fabrication and performance evaluation of a 22-channel direct reading atomic emission spectrometer using inductively coupled plasma as a source of excitation
The indigenous design, fabrication and performance evaluation of a polychromator, using inductively coupled plasma (ICP) as a source of excitation, are described. A concave holographic grating is used as the dispersing element and a Paschen-Runge mount is chosen to focus the spectra over a wide range along the Rowland circle. Twenty-two exit slits, mounted along the circle, precisely correspond to the wavelengths used for determination of up to twenty elements present in the plasma. Radiations emerging from the exit slits are detected by photomultiplier tubes placed behind them. The photomultiplier signal is recorded by an electronic system consisting of an integrator and a PC-based data acquisition system. The performance of the spectrometer has been evaluated with an ICP excitation source. Synthetic standards in deionized water containing a mixture of twenty impurities have been analysed. Typical determination limits observed for elements range from sub-ppm to ppm levels. All the elements present as impurities can be detected simultaneously. It is also observed that each element has a different emitting region in the ICP flame for which the maximum signal to the background is obtained. The determination limits obtained corresponding to these zones are the lowest. A study of the sensitive emitting zones for several elements has been carried out and the results are demonstrated by photographs of the ICP flame. The study will help in achieving the minimum value of determination limit for an impurity element
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