Alien Registration- Sullivan, Guy, Sr. (Eastport, Washington County)

https://digitalmaine.com/alien_docs/1235/thumbnail.jp

Chronic Disease Data And Analysis: Current State Of the Field

Chronic disease usually spans years of a person’s lifetime and includes a disease free period, a preclinical, or latent period, where there are few overt signs of disease, a clinical period where the disease manifests and is eventually diagnosed, and a follow-up period where the disease might progress steadily or remain stable. It is often of interest to investigate the relationship between risk factors measured at a point in time (usually during the disease free or preclinical period), and the development of disease at some future point (e.g., 10 years later). We outline some popular designs for the identification of subjects and discuss issues in measurement of risk factors for analysis of chronic disease. We discuss some of the complexities in these analyses, including the time dependent nature of the risk factors and missing data issues. We then describe some popular statistical modeling techniques and outline the situations in which each is appropriate. We conclude with some speculation toward future development in the area of chronic disease data and analysis

Exoplanet Catalogues

One of the most exciting developments in the field of exoplanets has been the progression from 'stamp-collecting' to demography, from discovery to characterisation, from exoplanets to comparative exoplanetology. There is an exhilaration when a prediction is confirmed, a trend is observed, or a new population appears. This transition has been driven by the rise in the sheer number of known exoplanets, which has been rising exponentially for two decades (Mamajek 2016). However, the careful collection, scrutiny and organisation of these exoplanets is necessary for drawing robust, scientific conclusions that are sensitive to the biases and caveats that have gone into their discovery. The purpose of this chapter is to discuss and demonstrate important considerations to keep in mind when examining or constructing a catalogue of exoplanets. First, we introduce the value of exoplanetary catalogues. There are a handful of large, online databases that aggregate the available exoplanet literature and render it digestible and navigable - an ever more complex task with the growing number and diversity of exoplanet discoveries. We compare and contrast three of the most up-to-date general catalogues, including the data and tools that are available. We then describe exoplanet catalogues that were constructed to address specific science questions or exoplanet discovery space. Although we do not attempt to list or summarise all the published lists of exoplanets in the literature in this chapter, we explore the case study of the NASA Kepler mission planet catalogues in some detail. Finally, we lay out some of the best practices to adopt when constructing or utilising an exoplanet catalogue.Comment: 14 pages, 6 figures. Invited review chapter, to appear in "Handbook of Exoplanets", edited by H.J. Deeg and J.A. Belmonte, section editor N. Batalh

Integration of airborne and ground observations of nitryl chloride in the Seoul metropolitan area and the implications on regional oxidation capacity during KORUS-AQ 2016

Nitryl chloride (ClNO2) is a radical reservoir species that releases chlorine radicals upon photolysis. An integrated analysis of the impact of ClNO2 on regional photochemistry in the Seoul metropolitan area (SMA) during the Korea-United States Air Quality Study (KORUS-AQ) 2016 field campaign is presented. Comprehensive multiplatform observations were conducted aboard the NASA DC-8 and at two ground sites (Olympic Park, OP; Taehwa Research Forest, TRF), representing an urbanized area and a forested suburban region, respectively. Positive correlations between daytime Cl2 and ClNO2 were observed at both sites, the slope of which was dependent on O3 levels. The possible mechanisms are explored through box model simulations constrained with observations. The overall diurnal variations in ClNO2 at both sites appeared similar but the nighttime variations were systematically different. For about half of the observation days at the OP site the level of ClNO2 increased at sunset but rapidly decreased at around midnight. On the other hand, high levels were observed throughout the night at the TRF site. Significant levels of ClNO2 were observed at both sites for 4-5 h after sunrise. Airborne observations, box model calculations, and back-trajectory analysis consistently show that these high levels of ClNO2 in the morning are likely from vertical or horizontal transport of air masses from the west. Box model results show that chlorine-radical-initiated chemistry can impact the regional photochemistry by elevating net chemical production rates of ozone by 25% in the morning

The P-SSP7 Cyanophage Has a Linear Genome with Direct Terminal Repeats

P-SSP7 is a T7-like phage that infects the cyanobacterium Prochlorococcus MED4. MED4 is a member of the high-light-adapted Prochlorococcus ecotypes that are abundant in the surface oceans and contribute significantly to primary production. P-SSP7 has become a model system for the investigation of T7-like phages that infect Prochlorococcus. It was classified as T7-like based on genome content and organization. However, because its genome assembled as a circular molecule, it was thought to be circularly permuted and to lack the direct terminal repeats found in other T7-like phages. Here we sequenced the ends of the P-SSP7 genome and found that the genome map is linear and contains a 206 bp repeat at both genome ends. Furthermore, we found that a 728 bp region of the genome originally placed downstream of the last ORF is actually located upstream of the first ORF on the genome map. These findings suggest that P-SSP7 is likely to use the direct terminal repeats for genome replication and packaging in a similar manner to other T7-like phages. Moreover, these results highlight the importance of experimentally verifying the ends of phage genomes, and will facilitate the use of P-SSP7 as a model for the correct assembly and end determination of the many T7-like phages isolated from the marine environment that are currently being sequenced

The impact generated by public and charity-funded research in the UK: A systematic literature review

Objective: To identify, synthesize and critically assess the empirical evidence of the impact generated by public and charity funded health research in the United Kingdom. Methods: We conducted a systematic literature review of the empirical evidence published in English in peer-reviewed journals between 2006 and 2017. Studies meeting the inclusion criteria were selected and their findings were analysed using the Payback Framework into five main categories: knowledge, benefits to future research and research use, benefits from informing policy and product development, health and health sector benefits and broader economic benefits. We assessed the studies for risk of selection, reporting and funding bias. Results: Thirteen studies met the inclusion criteria. The majority of the studies (10 out of 13) assessed impact at multiple domains including the main 5 key themes of the Payback Framework. All of them showed a positive impact of funded research on outcomes. Of those studies, one presented low risk of bias (8%), 6 studies were classified as presenting moderate risk of bias (46%) and 6 studies presented high risk of bias (46%). Conclusions: Empirical evidence on the impact of public and charity funded research is still limited and subject to funding and selection bias. More work is needed to establish the causal effects of funded research on academic outcomes, policy, practice and the broader economy

A remark on totally smooth renormings

[EN] E. Oja, T. Viil, andD. Werner showed, in Totally smooth renormings, Archiv der Mathematik, 112, 3, (2019), 269-281, that a weakly compactly generated Banach space ( X, center dot) with the property that every linear functional on X has a unique Hahn-Banach extension to the bidual X ** (the so-called Phelps' property U in X **, also known as the Hahn-Banach smoothness property) can be renormed to have the stronger property that for every subspace Y of X, every linear functional on Y has a unique Hahn-Banach extension to X ** (the so-called total smoothness property of the space). We mention here that this result holds in full generality -without any restriction on the space- and in a stronger form, thanks to a result ofM. Raja, On dual locally uniformly rotund norms, Israel Journal of Mathematics 129 (2002), 77-91.Supported by AEI/FEDER (project MTM2017-83262-C2-2-P of Ministerio de Economia y Competitividad), by Fundacion Seneca, Region de Murcia (Grant 19368/PI/14), and Universitat Politecnica de Valencia (A. J. Guirao). Supported by AEI/FEDER (project MTM2017-83262-C2-1-P of Ministerio de Economia y Competitividad) and Universitat Politecnica de Valencia (V. Montesinos). We thank the referees for their work, that neatly improved the original version of this note to its final form.Cobollo, C.; Guirao Sánchez, AJ.; Montesinos Santalucia, V. (2020). A remark on totally smooth renormings. Revista de la Real Academia de Ciencias Exactas Físicas y Naturales Serie A Matemáticas. 114(2):1-4. https://doi.org/10.1007/s13398-020-00831-5S141142Fabian, M., Habala, P., Hájek, P., Montesinos, V., Zizler, V.: Banach space theory: the basis of linear and nonlinear analysis. Springer, New York (2011)Fabian, M., Montesinos, V., Zizler, V.: Smoothness in Banach spaces. Selected problems. Rev. R. Acad. Cien. Ser. A. Mat. RACSAM. 100(1–2), 101–125 (2006)Ferrari, S., Orihuela, J., Raja, M.: Generalized metric properties of spheres and renorming of Banach spaces. Rev. R. Acad. Cienc. Exactas Fis. Natl. Ser. A Math. RACSAM. 113, 2655–2663 (2019)Foguel, S.R.: On a theorem by A. E. Taylor. Proc. Amer. Math. Soc. 9, 325 (1958)Godefroy, G.: Points de Namioka, espaces normants, applications à la théorie isométrique de la dualité. Israel J. Math. 38, 209–220 (1981)Guirao, A.J., Montesinos, V., Zizler, V.: Open Problems in the geometry and analysis of Banach spaces. Springer International Pub, Switzerland (2016)Harmand, P., Werner, D., Werner, W.: M-ideals in Banach spaces and Banach algebras. Lecture notes in math, vol. 1547. Springer, Berlin (1993)Haydon, R.: Locally uniformly rotund norms in Banach spaces and their duals. J. Funct. Anal. 254, 2023–2039 (2008)Oja, E., Viil, T., Werner, D.: Totally smooth renormings. Archiv. der. Mathematik. 112(3), 269–281 (2019)Phelps, R.R.: Uniqueness of Hahn–Banach extensions and unique best approximation. Trans. Amer. Math. Soc. 95, 238–255 (1960)Raja, M.: On dual locally uniformly rotund norms. Israel J. Math. 129, 77–91 (2002)Smith, R.J., Troyanski, S.L.: Renormings of $$C(K)$$ spaces. Rev. R. Acad. Cienc. Exactas Fís. Natl. Ser. A Math. RACSAM 104(2), 375–412 (2010)Sullivan, F.: Geometrical properties determined by the higher duals of a Banach space. Illinois J. Math. 21, 315–331 (1977)Taylor, A.E.: The extension of linear functionals. Duke Math. J. 5, 538–547 (1939