Ocorrência do fungo Colletotrichum gloeosporioides em mudas de bacurizeiro (Platonia insignis).

bitstream/item/131676/1/Comunicado-190-Ocorrencia-do-fungo-em-mudas-de-bacurizeiro.pd

Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.This study was supported by the Federal Ministry of Education and Research (BMBF, Germany, FKZ 01EO1502). This work was supported, in part, by the William Harvey Research Foundation and forms part of the research themes contributing to the translational research portfolio of Barts and the London Cardiovascular Biomedical Research Unit that is supported and funded by the National Institute of Health Research. This work also contributes to the Organ Protection research theme of the Barts Centre for Trauma Sciences supported by the Barts and The London Charity (Award 753/1722). JP was supported by the German Research Foundation SFB 1039. AH was supported by the Swiss National Science Foundation

Módulo VI: Enfermagem na atenção à saúde materno-fetal: pré-natal

Ministério da Saúd

Isothermal Shock Formation in Non-Equatorial Accretion Flows around Kerr Black Holes

We explore isothermal shock formation in non-equatorial, adiabatic accretion flows onto a rotating black hole, with possible application to some active galactic nuclei (AGNs). The isothermal shock jump conditions as well as the regularity condition, previously developed for one-dimensional (1D) flows in the equatorial plane, are extended to two-dimensional (2D), non-equatorial flows, to explore possible geometrical effects. The basic hydrodynamic equations with these conditions are self-consistently solved in the context of general relativity to explore the formation of stable isothermal shocks. We find that strong shocks are formed in various locations above the equatorial plane, especially around a rapidly-rotating black hole with the prograde flows (rather than a Schwarzschild black hole). The retrograde flows are generally found to develop weaker shocks. The energy dissipation across the shock in the hot non-equatorial flows above the cooler accretion disk may offer an attractive illuminating source for the reprocessed features, such as the iron fluorescence lines, which are often observed in some AGNs.Comment: 22 pages with 11 figures, presented at 5th international conference on high energy density laboratory astrophysics in Tucson, Arizona. accepted to Ap

Origin and interpretation of kilohertz QPOs from strange stars in X-ray binary system: theoretical hydrodynamical description

We model and interpret the Kilohertz QPOs from the hydrodynamical description of accretion disk around a rapidly rotating compact strange star. The higher QPO frequency is described by the viscous effects of accretion disk leading to shocks, while the lower one is taken to be the Keplerian motion of the accreting matter. Comparing our results with the observations for two of the fastest rotating compact stellar candidates namely, 4U~1636-53 and KS 1731-260, we find that they match to a very good approximation, thus interpreting them as strange stars.Comment: 5 pages including 1 figure; Accepted for publication in ApJLet

Liver Dysfunction and Phosphatidylinositol-3-Kinase Signalling in Early Sepsis: Experimental Studies in Rodent Models of Peritonitis

Background: Hepatic dysfunction and jaundice are traditionally viewed as late features of sepsis and portend poor outcomes. We hypothesized that changes in liver function occur early in the onset of sepsis, yet pass undetected by standard laboratory tests. Methods and Findings: In a long-term rat model of faecal peritonitis, biotransformation and hepatobiliary transport were impaired, depending on subsequent disease severity, as early as 6 h after peritoneal contamination. Phosphatidylinositol-3-kinase (PI3K) signalling was simultaneously induced at this time point. At 15 h there was hepatocellular accumulation of bilirubin, bile acids, and xenobiotics, with disturbed bile acid conjugation and drug metabolism. Cholestasis was preceded by disruption of the bile acid and organic anion transport machinery at the canalicular pole. Inhibitors of PI3K partially prevented cytokine-induced loss of villi in cultured HepG2 cells. Notably, mice lacking the PI3Kγ gene were protected against cholestasis and impaired bile acid conjugation. This was partially confirmed by an increase in plasma bile acids (e.g., chenodeoxycholic acid [CDCA] and taurodeoxycholic acid [TDCA]) observed in 48 patients on the day severe sepsis was diagnosed; unlike bilirubin (area under the receiver-operating curve: 0.59), these bile acids predicted 28-d mortality with high sensitivity and specificity (area under the receiver-operating curve: CDCA: 0.77; TDCA: 0.72; CDCA+TDCA: 0.87). Conclusions: Liver dysfunction is an early and commonplace event in the rat model of sepsis studied here; PI3K signalling seems to play a crucial role. All aspects of hepatic biotransformation are affected, with severity relating to subsequent prognosis. Detected changes significantly precede conventional markers and are reflected by early alterations in plasma bile acids. These observations carry important implications for the diagnosis of liver dysfunction and pharmacotherapy in the critically ill. Further clinical work is necessary to extend these concepts into clinical practice. Please see later in the article for the Editors' Summary

Acute-phase reactants after paediatric cardiac arrest. Procalcitonin as marker of immediate outcome

<p>Abstract</p> <p>Objective</p> <p>Procalcitonin (PCT) and C reactive protein (CRP) have been used as infection parameters. PCT increase correlates with the infection's severity, course, and mortality. Post-cardiocirculatory arrest syndrome may be related to an early systemic inflammatory response, and may possibly be associated with an endotoxin tolerance. Our objective was to report the time profile of PCT and CRP levels after paediatric cardiac arrest and to assess if they could be use as markers of immediate survival.</p> <p>Materials and methods</p> <p>A retrospective observational study set in an eight-bed PICU of a university hospital was performed during a period of two years. Eleven children younger than 14 years were admitted in the PICU after a cardiac arrest. PCT and CRP plasma concentrations were measured within the first 12 and 24 hours of admission.</p> <p>Results</p> <p>In survivors, PCT values increased 12 hours after cardiac arrest without further increase between 12 and 24 hours. In non survivors, PCT values increased 12 hours after cardiac arrest with further increase between 12 and 24 hours. Median PCT values (range) at 24 hours after cardiac arrest were 22.7 ng/mL (0.2 – 41.0) in survivors vs. 205.5 ng/mL (116.6 – 600.0) in non survivors (p < 0.05). CRP levels were elevated in all patients, survivors and non-survivors, at 12 and 24 hours without differences between both groups.</p> <p>Conclusion</p> <p>Measurement of PCT during the first 24 hours after paediatric cardiac arrest could serve as marker of mortality.</p

Psychological and psychiatric aspects of bone marrow transplantation

A intensidade e a complexidade envolvidas no transplante de medula óssea (TMO), em seus vários níveis, produz profundos efeitos psicológicos no paciente, na família e na equipe profissional. Ignorar esta realidade e reduzir os problemas do TMO a seus aspectos puramente técnicos pode trazer consequências catastróficas para o paciente e seus familiares e ameaçar a sobrevivência da equipe. Neste trabalho, são discutidos três aspectos muito importantes de saúde mental no TMO, enfatizando a prática desenvolvida na Unidade de TMO do HCFMRP: 1) os múltiplos papéis desempenhados pela assistência psiquiátrica na Unidade de TMO, desde a prescrição de psicofármacos até o apoio à equipe multiprofissional em grupos de reflexão; 2) uma análise dos sentimentos vivenciados pelo paciente submetido ao TMO nas diferentes fases do transplante (pré, intra e pós-TMO) sob a perspectiva da esperança de cura; 3) uma avaliação da qualidade de vida dos pacientes submetidos ao TMO, a curto e médio prazos, integrando vários instrumentos de análise, incluindo técnicas projetivas.The intensity and complexity involved in all levels of bone marrow transplantation (BMT) causes profound psychological effects on the patient, family and professional team. Ignoring this fact and reducing BMT issues to purely technical aspects may be catastrophical to the patients and his/her family and may challenge the survival of the program. In this work, three very important aspects of mental health in BMT are discussed: 1) multiple roles played by psychiatric assistance in BMT, from drug prescription through support of the team by group reflexion; 2) an analysis of emotions experienced by BMT patients in the different phases of transplantation (pre, intra- and post-) under the perspective of hope for cure ; 3) an evaluation of quality of life of patients submitted to BMT at medium and long terms, integrating various psychological instruments including projective techniques

Search for composite and exotic fermions at LEP 2

A search for unstable heavy fermions with the DELPHI detector at LEP is reported. Sequential and non-canonical leptons, as well as excited leptons and quarks, are considered. The data analysed correspond to an integrated luminosity of about 48 pb^{-1} at an e^+e^- centre-of-mass energy of 183 GeV and about 20 pb^{-1} equally shared between the centre-of-mass energies of 172 GeV and 161 GeV. The search for pair-produced new leptons establishes 95% confidence level mass limits in the region between 70 GeV/c^2 and 90 GeV/c^2, depending on the channel. The search for singly produced excited leptons and quarks establishes upper limits on the ratio of the coupling of the excited fermio