Quality Of Life And Epilepsy Surgery In Childhood And Adolescence.

Epilepsy can affect the quality of life (QOL) of patients. The temporal lobe epilepsy (TLE) is often refractory to medication, which has an adverse impact on QOL. The surgery can be a form to control the seizures and to improve the QOL of the patients. The aim of this study was to verify the QOL of children and adolescents with TLE who underwent surgery for epilepsy, comparing QOL before and after surgery and investigating which parameters showed improvement. We used semi-structured questionnaire in the pre-and post-surgery in 13 patients. The data were analyzed using the Wilcoxon test. The analysis showed that there was general improvement in the QOL postoperatively. There was improvement in general health issues, adverse effects of antiepileptic drugs and the relationship with parents. When properly indicated, epilepsy surgery improves quality of life of patients with TLE.6923-

The ATP-sensitive potassium channel blocker glibenclamide prevents renal ischemia/reperfusion injury in rats

The ATP-sensitive potassium channel blocker glibenclamide prevents renal ischemia/reperfusion injury in rats.BackgroundRenal ischemia/reperfusion (I/R) is a complex neutrophil-mediated syndrome. Adenosine-triphosphate (ATP)-sensitive potassium (KATP) channels are involved in neutrophil migration in vivo. In the present study, we have investigated the effects of glibenclamide, a KATP channel blocker, in renal I/R injury in rats.MethodsThe left kidney of the rats was excised through a flank incision and ischemia was performed in the contralateral kidney by total interruption of renal artery flow for 45 minutes. Renal perfusion was reestablished, and the kidney and lungs were removed for analysis of vascular permeability, neutrophil accumulation, and content of cytokines [tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-10] 4 and 24 hours later. Renal function was assessed by measuring creatinine, Na+, and K+ levels in the plasma and by determination of creatinine clearance. Drugs were administered subcutaneously after the onset of ischemia.ResultsReperfusion of the ischemic kidney induced local (kidney) and remote (lung) inflammatory injury and marked renal dysfunction. Glibenclamide (20 mg/kg) significantly inhibited the reperfusion-associated increase in vascular permeability, neutrophil accumulation, increase in TNF-α levels and nuclear factor-κB (NF-κB) translocation. These inhibitory effects were noticed in the kidney and lungs. Moreover, glibenclamide markedly ameliorated the renal dysfunction at 4 and 24 hours.ConclusionTreatment with glibenclamide is associated with inhibition of neutrophil recruitment and amelioration of renal dysfunction following renal I/R. Glibenclamide may have a therapeutic role in the treatment of renal I/R injury, such as after renal transplantation

Evaluation of the working ambient during propagation of Eucalyptus spp.

Nesta pesquisa, desenvolvida a partir de dados coletados em viveiro florestal no Vale do Rio Doce, MG, objetivou-se estudar os fatores ergonômicos relacionados às atividades exercidas nesses ambientes, visando à melhoria da saúde, do bem-estar, da segurança, do conforto e da produtividade dos trabalhadores. O objetivo específico foi a caracterização do ambiente de trabalho em relação ao conforto térmico, luminosidade e ruído. Os dados foram coletados através de medições do clima do local de trabalho, da luminosidade e do ruído. Os resultados indicaram que o ambiente de trabalho apresentou valores do Índice de Bulbo Úmido Termômetro de Globo, nas casas-de-vegetação, acima dos limites. A luminosidade encontrada foi considerada insuficiente nos postos de trabalho das atividades de estaqueamento e corte de macroestacas. Os níveis de ruído encontrados foram elevados nas atividades de lavagem e desinfecção de tubetes.The study reported here was conducted with data collected in a forest nursery in Vale do Rio Doce, Minas Gerais State-Brazil, with the objective of evaluating the ergonomic factors related to the activities carried out at this place, considering the various aspects like health, welfare, safety, comfort and productivity of the workers. The specific objective was the characterization of the working ambient in relation to the thermal comfort, light and noise. Data were collected about temperature, light and noise at the work posts. The results indicated that the ambient presented index values of the Moist Bulb Globe Thermometer above the limits in the green houses. The light was considered insufficient at the work post for the activities such as staking and macro cuttings. The noise levels were high in the areas where the activities of washing and disinfecting of tubes were being carried out

Comfort from the perspective of families of people hospitalized in the intensive care unit

This study aimed at understanding the meaning of comfort to the families of people in intensive care units. It consists of a qualitative study carried out in the intensive care unit of a hospital in Salvador-Bahia. Fourteen family members were interviewed. The authors utilized the theoretical principles of symbolic interactionism and the technique of qualitative data analysis. Results indicated that the categories Safety, Receptiveness, Information, Proximity, Social and Spiritual Support, Convenience and Integration expressed the meaning of comfort, which was comprised of reliability in terms of technical-scientific competence and a supportive and sensitive attitude of the team, chance of recovery, access to information and the opportunity to be close to the patient, support of people in their social life, spiritual sources and the environmental structure of the hospital, preservation of self-care and routine activities. It was concluded that the family is important as objects and subjects of the actions in healthcare and must be the focus in public health policies and programs in Brazil