173 research outputs found
Elastic-to-plastic crossover below the peak effect in the vortex solid of YBa2Cu3O7 single crystals
We report on transport and ac susceptibility studies below the peak effect in
twinned YBa2Cu3O7 single crystals. We find that disorder generated at the peak
effect can be partially inhibited by forcing vortices to move with an ac
driving current. The vortex system can be additionally ordered below a
well-defined temperature where elastic interactions between vortices overcome
pinning-generated stress and a plastic to elastic crossover seems to occur. The
combined effect of these two processes results in vortex structures with
different mobilities that give place to history effects.Comment: 4 pages, 4 figures. Published in PRB Rapid Comm., February 1, 200
Baryogenesis vs. proton stability in theories with extra dimensions
We propose a new scenario of baryogenesis in the context of theories with
large extra dimensions. The baryon number is almost conserved at zero
temperature by means of a localization mechanism recently analyzed by
Arkani-Hamed and Schmaltz: leptons and quarks are located at two slightly
displaced positions in the extra space, and this naturally suppresses the
interactions which ``convert'' the latter in the former. We show that this is
expected to be no longer true when finite temperature effects are taken into
account. The whole scenario is first presented in its generality, without
referring to the bulk geometry or to the specific mechanism which may generate
the baryon asymmetry. As an example, we then focus on a baryogenesis model
reminiscent of GUT baryogenesis. The Sakharov out of equilibrium condition is
satisfied by assuming nonthermal production of the bosons that induce baryon
number violation.Comment: 10 pages, 1 figur
Super-acceleration on the Brane by Energy Flow from the Bulk
We consider a brane cosmological model with energy exchange between brane and
bulk. Parameterizing the energy exchange term by the scale factor and Hubble
parameter, we are able to exactly solve the modified Friedmann equation on the
brane. In this model, the equation of state for the effective dark energy has a
transition behavior changing from to , while
the equation of state for the dark energy on the brane has . Fitting data
from type Ia supernova, Sloan Digital Sky Survey and Wilkinson Microwave
Anisotropy Probe, our universe is predicted now in the state of
super-acceleration with .Comment: Revtex, 11 pages including 2 figures,v2: tpos fixed, references
added, to appear in JCA
Dynamical Lorentz simmetry breaking from 3+1 Axion-Wess-Zumino model
We study the renormalizable abelian vector-field models in the presence of
the Wess-Zumino interaction with the pseudoscalar matter. The renormalizability
is achieved by supplementing the standard kinetic term of vector fields with
higher derivatives. The appearance of fourth power of momentum in the
vector-field propagator leads to the super-renormalizable theory in which the
-function, the vector-field renormalization constant and the anomalous
mass dimension are calculated exactly. It is shown that this model has the
infrared stable fixed point and its low-energy limit is non-trivial. The
modified effective potential for the pseudoscalar matter leads to the possible
occurrence of dynamical breaking of the Lorentz symmetry. This phenomenon is
related to the modification of Electrodynamics by means of the Chern-Simons
(CS) interaction polarized along a constant CS vector. Its presence makes the
vacuum optically active that has been recently estimated from astrophysical
data. We examine two possibilities for the CS vector to be time-like or
space-like, under the assumption that it originates from v.e.v. of some
pseudoscalar matter and show that only the latter one is consistent in the
framework of the AWZ model, because a time-like CS vector makes the vacuum
unstable under pairs creation of tachyonic photon modes with the finite vacuum
decay rate.Comment: 33 pages, no Figures, Plain TeX, submitted to Phys. Rev.
Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia
BACKGROUND
Coronavirus disease 2019 (Covid-19) is associated with immune dysregulation and hyperinflammation, including elevated interleukin-6 levels. The use of tocilizu- mab, a monoclonal antibody against the interleukin-6 receptor, has resulted in better outcomes in patients with severe Covid-19 pneumonia in case reports and retrospective observational cohort studies. Data are needed from randomized, placebo-controlled trials.
METHODS
In this phase 3 trial, we randomly assigned patients who were hospitalized with severe Covid-19 pneumonia in a 2:1 ratio receive a single intravenous infusion of tocilizumab (at a dose of 8 mg per kilogram of body weight) or placebo. Approxi- mately one quarter of the participants received a second dose of tocilizumab or placebo 8 to 24 hours after the first dose. The primary outcome was clinical status at day 28 on an ordinal scale ranging from 1 (discharged or ready for discharge) to 7 (death) in the modified intention-to-treat population, which included all the patients who had received at least one dose of tocilizumab or placebo.
RESULTS
Of the 452 patients who underwent randomization, 438 (294 in the tocilizumab group and 144 in the placebo group) were included in the primary and secondary analyses. The median value for clinical status on the ordinal scale at day 28 was 1.0 (95% confidence interval [CI], 1.0 to 1.0) in the tocilizumab group and 2.0 (non-ICU hospitalization without supplemental oxygen) (95% CI, 1.0 to 4.0) in the placebo group (between-group difference, −1.0; 95% CI, −2.5 to 0; P=0.31 by the van Elteren test). In the safety population, serious adverse events occurred in 103 of 295 patients (34.9%) in the tocilizumab group and in 55 of 143 patients (38.5%) in the placebo group. Mortality at day 28 was 19.7% in the tocilizumab group and 19.4% in the placebo group (weighted difference, 0.3 percentage points (95% CI, –7.6 to 8.2; nominal P=0.94).
CONCLUSIONS
In this randomized trial involving hospitalized patients with severe Covid-19 pneu- monia, the use of tocilizumab did not result in significantly better clinical status or lower mortality than placebo at 28 days. (Funded by F. Hoffmann–La Roche and the Department of Health and Human Services; COVACTA ClinicalTrials.gov num- ber, NCT04320615.
What does inflation really predict?
If the inflaton potential has multiple minima, as may be expected in, e.g.,
the string theory "landscape", inflation predicts a probability distribution
for the cosmological parameters describing spatial curvature (Omega_tot), dark
energy (rho_Lambda, w, etc.), the primordial density fluctuations (Omega_tot,
dark energy (rho_Lambda, w, etc.). We compute this multivariate probability
distribution for various classes of single-field slow-roll models, exploring
its dependence on the characteristic inflationary energy scales, the shape of
the potential V and and the choice of measure underlying the calculation. We
find that unless the characteristic scale Delta-phi on which V varies happens
to be near the Planck scale, the only aspect of V that matters observationally
is the statistical distribution of its peaks and troughs. For all energy scales
and plausible measures considered, we obtain the predictions Omega_tot ~
1+-0.00001, w=-1 and rho_Lambda in the observed ballpark but uncomfortably
high. The high energy limit predicts n_s ~ 0.96, dn_s/dlnk ~ -0.0006, r ~ 0.15
and n_t ~ -0.02, consistent with observational data and indistinguishable from
eternal phi^2-inflation. The low-energy limit predicts 5 parameters but prefers
larger Q and redder n_s than observed. We discuss the coolness problem, the
smoothness problem and the pothole paradox, which severely limit the viable
class of models and measures. Our findings bode well for detecting an
inflationary gravitational wave signature with future CMB polarization
experiments, with the arguably best-motivated single-field models favoring the
detectable level r ~ 0.03. (Abridged)Comment: Replaced to match accepted JCAP version. Improved discussion,
references. 42 pages, 17 fig
Use of Lichen and Moss in Assessment of Forest Contamination with Heavy Metals in Praded and Glacensis Euroregions (Poland and Czech Republic)
The concentrations of selected metals—Cr, Ni, Cu, Zn, Cd, and Pb—were determined in the samples of Hypogymnia physodes lichen and Pleurozium schreberi moss collected in Polish and Czech Euroregions Praded and Glacensis. More specifically, the samples were collected in Bory Stobrawskie, Bory Niemodlińskie, and Kotlina Kłodzka (Poland) and in Jeseniki (Czech Republic). The concentration of metals in the samples was measured using the atomic absorption spectrometry (flame AAS technique and electrothermal atomization AAS technique). The results were used to calculate the comparison factor (CF) that quantifies the difference in concentration of a given bioavailable analyte × accumulated in lichens and mosses: CF = 2 (cx,lichen − cx,moss) (cx,lichen + cx,moss)−1. The values of CF greater than 0.62 indicate the most probable location of heavy metals deposited in the considered area. In this work, the method was used to show a significant contribution of urban emissions to the deposition of heavy metals in the area of Bory Stobrawskie and in the vicinity of Kłodzko City
Accidental Inflation in String Theory
We show that inflation in type IIB string theory driven by the volume modulus
can be realized in the context of the racetrack-based Kallosh-Linde model (KL)
of moduli stabilization. Inflation here arises through the volume modulus
slow-rolling down from a flat hill-top or inflection point of the scalar
potential. This situation can be quite generic in the landscape, where by
uplifting one of the two adjacent minima one can turn the barrier either to a
flat saddle point or to an inflection point supporting eternal inflation. The
resulting spectral index is tunable in the range of 0.93 < n_s < 1, and there
is only negligible production of primordial gravitational waves r < 10^{-6}.
The flatness of the potential in this scenario requires fine-tuning, which may
be justified taking into account the exponential reward by volume factors
preferring the regions of the universe with the maximal amount of slow-roll
inflation. This consideration leads to a tentative prediction of the spectral
index or depending on whether the
potential has a symmetry phi -> - phi or not.Comment: 15 pages, 6 figures, LaTeX, uses RevTex
Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia
BACKGROUND
Coronavirus disease 2019 (Covid-19) is associated with immune dysregulation and hyperinflammation, including elevated interleukin-6 levels. The use of tocilizumab, a monoclonal antibody against the interleukin-6 receptor, has resulted in better outcomes in patients with severe Covid-19 pneumonia in case reports and retrospective observational cohort studies. Data are needed from randomized, placebo-controlled trials.
METHODS
In this phase 3 trial, we randomly assigned patients who were hospitalized with severe Covid-19 pneumonia in a 2:1 ratio receive a single intravenous infusion of tocilizumab (at a dose of 8 mg per kilogram of body weight) or placebo. Approximately one quarter of the participants received a second dose of tocilizumab or placebo 8 to 24 hours after the first dose. The primary outcome was clinical status at day 28 on an ordinal scale ranging from 1 (discharged or ready for discharge) to 7 (death) in the modified intention-to-treat population, which included all the patients who had received at least one dose of tocilizumab or placebo.
RESULTS
Of the 452 patients who underwent randomization, 438 (294 in the tocilizumab group and 144 in the placebo group) were included in the primary and secondary analyses. The median value for clinical status on the ordinal scale at day 28 was 1.0 (95% confidence interval [CI], 1.0 to 1.0) in the tocilizumab group and 2.0 (non-ICU hospitalization without supplemental oxygen) (95% CI, 1.0 to 4.0) in the placebo group (between-group difference, −1.0; 95% CI, −2.5 to 0; P=0.31 by the van Elteren test). In the safety population, serious adverse events occurred in 103 of 295 patients (34.9%) in the tocilizumab group and in 55 of 143 patients (38.5%) in the placebo group. Mortality at day 28 was 19.7% in the tocilizumab group and 19.4% in the placebo group (weighted difference, 0.3 percentage points; 95% CI, –7.6 to 8.2; nominal P=0.94).
CONCLUSIONS
In this randomized trial involving hospitalized patients with severe Covid-19 pneumonia, the use of tocilizumab did not result in significantly better clinical status or lower mortality than placebo at 28 days. (Funded by F. Hoffmann–La Roche and the Department of Health and Human Services; COVACTA ClinicalTrials.gov number, NCT04320615
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