Problemas atuais da juticultura amazônica.

No presente trabalho, os autores procuraram expor os problemas atuais que entravam o desenvolvimento da juticultura amazônica, ressaltando a importância marcante da produção das fibras desta tiliácea como fonte da manutenção do mercado interno brasileiro de matéria prima necessária ao abastecimento do parque nacional de aniagem. Os problemas considerados, no trabalho em questão, foram: 1) problemas de ordem agrícola, 2) problemas de ordem sócio-econômica. Procurou-se, também, de forma sintética, expor a situação do mercado nacional e as possibilidades de exportação. Como conclusão, os autores admitem a necessidade urgente e prioritária de se estimular econômicamente o juticultor a fim de que se possa posteriormente mostrar que a quantidade e qualidade do produto depende em grande parte dos problemas culturais e tecnológicos.Separata da Pesquisa Agropecuária Brasileira, v. 1, p. 1-6, 1966

Chaos and a Resonance Mechanism for Structure Formation in Inflationary Models

We exhibit a resonance mechanism of amplification of density perturbations in inflationary mo-dels, using a minimal set of ingredients (an effective cosmological constant, a scalar field minimally coupled to the gravitational field and matter), common to most models in the literature of inflation. This mechanism is based on the structure of homoclinic cylinders, emanating from an unstable periodic orbit in the neighborhood of a saddle-center critical point, present in the phase space of the model. The cylindrical structure induces oscillatory motions of the scales of the universe whenever the orbit visits the neighborhood of the saddle-center, before the universe enters a period of exponential expansion. The oscillations of the scale functions produce, by a resonance mechanism, the amplification of a selected wave number spectrum of density perturbations, and can explain the hierarchy of scales observed in the actual universe. The transversal crossings of the homoclinic cylinders induce chaos in the dynamics of the model, a fact intimately connected to the resonance mechanism occuring immediately before the exit to inflation.Comment: 4 pages. This essay received an Honorable Mention from the Gravity Research Foundation, 1998-Ed. To appear in Mod. Phys. Lett.

The mathematical description of the electrosynthesis of composites of oxy-hydroxycompounds cobalt with polypyrrole overooxidazed

The electrosynthesis of the composite with of the overoxidized polypyrrole with cobalt oxy-hydroxide in strongly acidic media has been described mathematically, using linear stability theory and bifurcation analysis. The steadystates stability conditions and oscillatory and monotonic instability requirements have been described too. The system´s behavior was compared with behavior of other systems with overoxidation, electropolymerization of heterocyclic compounds and electrosynthesis of the cobalt oxy-hydroxides

The low dimensional dynamical system approach in General Relativity: an example

In this paper we explore one of the most important features of the Galerkin method, which is to achieve high accuracy with a relatively modest computational effort, in the dynamics of Robinson-Trautman spacetimes.Comment: 7 pages, 5 figure

Population expansion in the North African Late Pleistocene signalled by mitochondrial DNA haplogroup U6

Background <br/> The archaeology of North Africa remains enigmatic, with questions of population continuity versus discontinuity taking centre-stage. Debates have focused on population transitions between the bearers of the Middle Palaeolithic Aterian industry and the later Upper Palaeolithic populations of the Maghreb, as well as between the late Pleistocene and Holocene. <br/> Results Improved resolution of the mitochondrial DNA (mtDNA) haplogroup U6 phylogeny, by the screening of 39 new complete sequences, has enabled us to infer a signal of moderate population expansion using Bayesian coalescent methods. To ascertain the time for this expansion, we applied both a mutation rate accounting for purifying selection and one with an internal calibration based on four approximate archaeological dates: the settlement of the Canary Islands, the settlement of Sardinia and its internal population re-expansion, and the split between haplogroups U5 and U6 around the time of the first modern human settlement of the Near East. <br/> Conclusions <br/> A Bayesian skyline plot placed the main expansion in the time frame of the Late Pleistocene, around 20 ka, and spatial smoothing techniques suggested that the most probable geographic region for this demographic event was to the west of North Africa. A comparison with U6's European sister clade, U5, revealed a stronger population expansion at around this time in Europe. Also in contrast with U5, a weak signal of a recent population expansion in the last 5,000 years was observed in North Africa, pointing to a moderate impact of the late Neolithic on the local population size of the southern Mediterranean coast

Avaliação, seleção e recomendação de cutlivares de arroz de várzeas em Minas Gerais de 1997 a 2002.

A fim de tornar a orizicultura irrigada uma atividade mais atrativa, a EPAMIG desenvolve, em parceria com a EMBRAPA Arroz e Feijão, pesquisas de melhoramento genético de arroz de várzeas com o objetivo de obter cultivares superiores às já recomendadas, tanto em produtividade como em aceitação comercial

Community-Acquired MRSA Pyomyositis: Case Report and Review of the Literature

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is responsible for a broad range of infections. We report the case of a 46-year-old gentleman with a history of untreated, uncomplicated Hepatitis C who presented with a 2-month history of back pain and was found to have abscesses in his psoas and right paraspinal muscles with subsequent lumbar spine osteomyelitis. Despite drainage and appropriate antibiotic management the patient's clinical condition deteriorated and he developed new upper extremity weakness and sensory deficits on physical exam. Repeat imaging showed new, severe compression of the spinal cord and cauda equina from C1 to the sacrum by a spinal epidural abscess. After surgical intervention and continued medical therapy, the patient recovered completely. This case illustrates a case of CA-MRSA pyomyositis that progressed to lumbar osteomyelitis and a spinal epidural abscess extending the entire length of the spinal canal

Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors

BACKGROUND: The presence of somatic mitochondrial DNA (mtDNA) mutations in cancer cells has been interpreted in controversial ways, ranging from random neutral accumulation of mutations, to positive selection for high pathogenicity, or conversely to purifying selection against high pathogenicity variants as occurs at the population level. METHODS: Here we evaluated the predicted pathogenicity of somatic mtDNA mutations described in cancer and compare these to the distribution of variations observed in the global human population and all possible protein variations that could occur in human mtDNA. We focus on oncocytic tumors, which are clearly associated with mitochondrial dysfunction. The protein variant pathogenicity was predicted using two computational methods, MutPred and SNPs&GO. RESULTS: The pathogenicity score of the somatic mtDNA variants were significantly higher in oncocytic tumors compared to non-oncocytic tumors. Variations in subunits of Complex I of the electron transfer chain were significantly more common in tumors with the oncocytic phenotype, while variations in Complex V subunits were significantly more common in non-oncocytic tumors. CONCLUSIONS: Our results show that the somatic mtDNA mutations reported over all tumors are indistinguishable from a random selection from the set of all possible amino acid variations, and have therefore escaped the effects of purifying selection that act strongly at the population level. We show that the pathogenicity of somatic mtDNA mutations is a determining factor for the oncocytic phenotype. The opposite associations of the Complex I and Complex V variants with the oncocytic and non-oncocytic tumors implies that low mitochondrial membrane potential may play an important role in determining the oncocytic phenotype

Epigenomics in Hurthle Cell Neoplasms: Filling in the Gaps Towards Clinical Application

It has been widely described that cancer genomes have frequent alterations to the epigenome, including epigenetic silencing of various tumor suppressor genes with functions in almost all cancer-relevant signalling pathways, such as apoptosis, cell proliferation, cell migration and DNA repair. Epigenetic alterations comprise DNA methylation, histone modification, and microRNAs dysregulated expression and they play a significant role in the differentiation and proliferation properties of TC. In this review, our group assessed the published evidence on the tumorigenic role of epigenomics in Hurthle cell neoplasms (HCN), highlighting the yet limited, heteregeneous and non-validated data preventing its current use in clinical practice, despite the well developed assessment techniques available. The identified evidence gaps call for a joint endeavour by the medical community towards a deeper and more systematic study of HCN, aiming at defining epigenetic markers in early diagnose, allowing for accurate stratification of maligancy and disease risk and for effective systemic treatment.This work was financed by FEDER—Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 —Operacional Programme for Competitiveness and Internationalization (POCI), Portugal 2020, and by Portuguese funds through FCT - Fundação para a Ciência e a Tecnologia/ Ministério da Ciência, Tecnologia e Inovação in the framework of the project “Institute for Research and Innovation in Health Sciences” (POCI-01-0145-FEDER-007274). Additional funding by the European Regional Development Fund (ERDF) through the Operational Programme for Competitiveness and Internationalization—COMPETE2020, and Portuguese national funds via FCT, under project POCI-01-0145-FEDER-016390: CANCEL STEM and from the FCT under the project POCI-01-0145-FEDER-031438: The other faces of telomerase: Looking beyond tumor immortalization (PDTC/MED_ONC/ 31438/2017). Additional funding through the Sociedade Portuguesa de Endocrinologia, Diabetes e Metabolismo – Bolsa Edward Limbert MERCK/SPEDM 2019. SC is supported by FCT in the framework of a PhD grant (SFRH/BD/ 147650/2019)