651 research outputs found
The unique resistance and resilience of the Nigerian West African Dwarf goat to gastrointestinal nematode infections
<p>Abstract</p> <p>Background</p> <p>West African Dwarf (WAD) goats serve an important role in the rural village economy of West Africa, especially among small-holder livestock owners. They have been shown to be trypanotolerant and to resist infections with <it>Haemonchus contortus </it>more effectively than any other known breed of goat.</p> <p>Methods</p> <p>In this paper we review what is known about the origins of this goat breed, explain its economic importance in rural West Africa and review the current status of our knowledge about its ability to resist parasitic infections.</p> <p>Conclusions</p> <p>We suggest that its unique capacity to show both trypanotolerance and resistance to gastrointestinal (GI) nematode infections is immunologically based and genetically endowed, and that knowledge of the underlying genes could be exploited to improve the capacity of more productive wool and milk producing, but GI nematode susceptible, breeds of goats to resist infection, without recourse to anthelmintics. Either conventional breeding allowing introgression of resistance alleles into susceptible breeds, or transgenesis could be exploited for this purpose. Appropriate legal protection of the resistance alleles of WAD goats might provide a much needed source of revenue for the countries in West Africa where the WAD goats exist and where currently living standards among rural populations are among the lowest in the world.</p
The Expanding Fireball of Nova Delphini 2013
A classical nova occurs when material accreting onto the surface of a white
dwarf in a close binary system ignites in a thermonuclear runaway. Complex
structures observed in the ejecta at late stages could result from interactions
with the companion during the common envelope phase. Alternatively, the
explosion could be intrinsically bipolar, resulting from a localized ignition
on the surface of the white dwarf or as a consequence of rotational distortion.
Studying the structure of novae during the earliest phases is challenging
because of the high spatial resolution needed to measure their small sizes.
Here we report near-infrared interferometric measurements of the angular size
of Nova Delphini 2013, starting from one day after the explosion and continuing
with extensive time coverage during the first 43 days. Changes in the apparent
expansion rate can be explained by an explosion model consisting of an
optically thick core surrounded by a diffuse envelope. The optical depth of the
ejected material changes as it expands. We detect an ellipticity in the light
distribution, suggesting a prolate or bipolar structure that develops as early
as the second day. Combining the angular expansion rate with radial velocity
measurements, we derive a geometric distance to the nova of 4.54 +/- 0.59 kpc
from the Sun.Comment: Published in Nature. 32 pages. Final version available at
http://www.nature.com/nature/journal/v515/n7526/full/nature13834.htm
Geographic constraints on social network groups
Social groups are fundamental building blocks of human societies. While our
social interactions have always been constrained by geography, it has been
impossible, due to practical difficulties, to evaluate the nature of this
restriction on social group structure. We construct a social network of
individuals whose most frequent geographical locations are also known. We also
classify the individuals into groups according to a community detection
algorithm. We study the variation of geographical span for social groups of
varying sizes, and explore the relationship between topological positions and
geographic positions of their members. We find that small social groups are
geographically very tight, but become much more clumped when the group size
exceeds about 30 members. Also, we find no correlation between the topological
positions and geographic positions of individuals within network communities.
These results suggest that spreading processes face distinct structural and
spatial constraints.Comment: 10 pages, 5 figure
A lack of functional NK1 receptors explains most, but not all, abnormal behaviours of NK1R-/- mice
Mice lacking functional neurokinin-1 receptors (NK1R-/-) display abnormal behaviours seen in Attention Deficit Hyperactivity Disorder (hyperactivity, impulsivity and inattentiveness). These abnormalities were evident when comparing the behaviour of separate (inbred: 'Hom') wildtype and NK1R-/- mouse strains. Here, we investigated whether the inbreeding protocol could influence their phenotype by comparing the behaviour of these mice with that of wildtype (NK1R+/+) and NK1R-/- progeny of heterozygous parents ('Het', derived from the same inbred strains). First, we recorded the spontaneous motor activity of the two colonies/genotypes, over 7 days. This continuous monitoring also enabled us to investigate whether the diurnal rhythm in motor activity differs in the two colonies/genotypes. NK1R-/- mice from both colonies were hyperactive compared with their wildtypes and their diurnal rhythm was also disrupted. Next, we evaluated the performance of the four groups of mice in the 5-Choice Serial Reaction-Time Task (5-CSRTT). During training, NK1R-/- mice from both colonies expressed more impulsive and perseverative behaviour than their wildtypes. During testing, only NK1R-/- mice from the Hom colony were more impulsive than their wildtypes, but NK1R-/- mice from both colonies were more perseverative. There were no colony differences in inattentiveness. Moreover, a genotype difference in this measure depended on time of day. We conclude that the hyperactivity, perseveration and, possibly, inattentiveness of NK1R-/- mice is a direct consequence of a lack of functional NK1R. However, the greater impulsivity of NK1R-/- mice depended on an interaction between a functional deficit of NK1R and other (possibly environmental and/or epigenetic) factors. Comparison of the homozygous progeny of homozygous and heterozygous breeding-pairs reveals that certain behavioural abnormalities in NK1R-/- mice are explained by their genotype, alone, but others rest on an interaction between genotype and epigenetic/environmental factors
Dataset of British English speech recordings for psychoacoustics and speech processing research: The clarity speech corpus
This paper presents the Clarity Speech Corpus, a publicly available, forty speaker British English speech dataset. The corpus was created for the purpose of running listening tests to gauge speech intelligibility and quality in the Clarity Project, which has the goal of advancing speech signal processing by hearing aids through a series of challenges. The dataset is suitable for machine learning and other uses in speech and hearing technology, acoustics and psychoacoustics. The data comprises recordings of approximately 10,000 sentences drawn from the British National Corpus (BNC) with suitable length, words and grammatical construction for speech intelligibility testing. The collection process involved the selection of a subset of BNC sentences, the recording of these produced by 40 British English speakers, and the processing of these recordings to create individual sentence recordings with associated transcripts and metadata
Consensus clustering in complex networks
The community structure of complex networks reveals both their organization
and hidden relationships among their constituents. Most community detection
methods currently available are not deterministic, and their results typically
depend on the specific random seeds, initial conditions and tie-break rules
adopted for their execution. Consensus clustering is used in data analysis to
generate stable results out of a set of partitions delivered by stochastic
methods. Here we show that consensus clustering can be combined with any
existing method in a self-consistent way, enhancing considerably both the
stability and the accuracy of the resulting partitions. This framework is also
particularly suitable to monitor the evolution of community structure in
temporal networks. An application of consensus clustering to a large citation
network of physics papers demonstrates its capability to keep track of the
birth, death and diversification of topics.Comment: 11 pages, 12 figures. Published in Scientific Report
Characterizing the community structure of complex networks
Community structure is one of the key properties of complex networks and
plays a crucial role in their topology and function. While an impressive amount
of work has been done on the issue of community detection, very little
attention has been so far devoted to the investigation of communities in real
networks. We present a systematic empirical analysis of the statistical
properties of communities in large information, communication, technological,
biological, and social networks. We find that the mesoscopic organization of
networks of the same category is remarkably similar. This is reflected in
several characteristics of community structure, which can be used as
``fingerprints'' of specific network categories. While community size
distributions are always broad, certain categories of networks consist mainly
of tree-like communities, while others have denser modules. Average path
lengths within communities initially grow logarithmically with community size,
but the growth saturates or slows down for communities larger than a
characteristic size. This behaviour is related to the presence of hubs within
communities, whose roles differ across categories. Also the community
embeddedness of nodes, measured in terms of the fraction of links within their
communities, has a characteristic distribution for each category. Our findings
are verified by the use of two fundamentally different community detection
methods.Comment: 15 pages, 20 figures, 4 table
Clarity-2021 challenges : machine learning challenges for advancing hearing aid processing
In recent years, rapid advances in speech technology have been made possible by machine learning challenges such as CHiME, REVERB, Blizzard, and Hurricane. In the Clarity project, the machine learning approach is applied to the problem of hearing aid processing of speech-in-noise, where current technology in enhancing the speech signal for the hearing aid wearer is often ineffective. The scenario is a (simulated) cuboid-shaped living room in which there is a single listener, a single target speaker and a
single interferer, which is either a competing talker or domestic noise. All sources are static, the target is always within ±30◦ azimuth of the listener and at the same elevation, and the interferer is an omnidirectional point source at the same elevation. The target speech comes from an open source 40- speaker British English speech database collected for this purpose. This paper provides a baseline description of the round one Clarity challenges for both enhancement (CEC1) and prediction (CPC1). To the authors’ knowledge, these are the first machine learning challenges to consider the problem of hearing aid speech signal processin
Criminal and Noncriminal Psychopathy: The Devil is in the Detail
Brooks, NS ORCiD: 0000-0003-1784-099XPsychopathy is prevalent and problematic in criminal populations, but is also found to be present in noncriminal populations. In 1992, Robert Hare declared that psychopaths may also “be found in the boardroom”, which has since been followed by an interest in the issue of noncriminal, or even successful, psychopathy. In this chapter, the paradox of criminal and noncriminal psychopathy is discussed with specific attention given to the similarities and differences that account for psychopathic personality across contexts. That psychopathy is a condition typified by a constellation of traits and behaviours requires wider research across diverse populations, and thus the streams of research related to criminal and noncriminal psychopathy are presented and the implications of these contrasting streams are explored
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