1,851 research outputs found
The use of segmented regression in analysing interrupted time series studies : an example in pre-hospital ambulance care
Peer reviewedPublisher PD
Virtual signatures of dark sectors in Higgs couplings
Where collider searches for resonant invisible particles loose steam, dark
sectors might leave their trace as virtual effects in precision observables.
Here we explore this option in the framework of Higgs portal models, where a
sector of dark fermions interacts with the standard model through a strong
renormalizable coupling to the Higgs boson. We show that precise measurements
of Higgs-gauge and triple Higgs interactions can probe dark fermions up to the
TeV scale through virtual corrections. Observation prospects at the LHC and
future lepton colliders are discussed for the so-called singlet-doublet model
of Majorana fermions, a generalization of the bino-higgsino scenario in
supersymmetry. We advocate a two-fold search strategy for dark sectors through
direct and indirect observables.Comment: 20 pages, 7 figures, 1 tabl
Intervention planning and modification of the BUMP intervention: a digital intervention for the early detection of raised blood pressure in pregnancy
Background: Hypertensive disorders in pregnancy, particularly pre-eclampsia, pose a substantial health risk for both maternal and foetal outcomes. The BUMP (Blood Pressure Self-Monitoring in Pregnancy) interventions are being tested in a trial. They aim to facilitate the early detection of raised blood pressure through self-monitoring. This article outlines how the self-monitoring interventions in the BUMP trial were developed and modified using the person-based approach to promote engagement and adherence.
Methods: Key behavioural challenges associated with blood pressure self-monitoring in pregnancy were identified through synthesising qualitative pilot data and existing evidence, which informed guiding principles for the development process. Social cognitive theory was identified as an appropriate theoretical framework. A testable logic model was developed to illustrate the hypothesised processes of change associated with the intervention. Iterative qualitative feedback from women and staff informed modifications to the participant materials.
Results: The evidence synthesis suggested women face challenges integrating self-monitoring into their lives and that adherence is challenging at certain time points in pregnancy (for example, starting maternity leave). Intervention modification included strategies to address adherence but also focussed on modifying outcome expectancies, by providing messages explaining pre-eclampsia and outlining the potential benefits of self-monitoring.
Conclusions: With an in-depth understanding of the target population, several methods and approaches to plan and develop interventions specifically relevant to pregnant women were successfully integrated, to address barriers to behaviour change while ensuring they are easy to engage with, persuasive and acceptable
A method for quantifying sectoral optic disc pallor in fundus photographs and its association with peripapillary RNFL thickness
Purpose: To develop an automatic method of quantifying optic disc pallor in
fundus photographs and determine associations with peripapillary retinal nerve
fibre layer (pRNFL) thickness.
Methods: We used deep learning to segment the optic disc, fovea, and vessels
in fundus photographs, and measured pallor. We assessed the relationship
between pallor and pRNFL thickness derived from optical coherence tomography
scans in 118 participants. Separately, we used images diagnosed by clinical
inspection as pale (N=45) and assessed how measurements compared to healthy
controls (N=46). We also developed automatic rejection thresholds, and tested
the software for robustness to camera type, image format, and resolution.
Results: We developed software that automatically quantified disc pallor
across several zones in fundus photographs. Pallor was associated with pRNFL
thickness globally (\b{eta} = -9.81 (SE = 3.16), p < 0.05), in the temporal
inferior zone (\b{eta} = -29.78 (SE = 8.32), p < 0.01), with the nasal/temporal
ratio (\b{eta} = 0.88 (SE = 0.34), p < 0.05), and in the whole disc (\b{eta} =
-8.22 (SE = 2.92), p < 0.05). Furthermore, pallor was significantly higher in
the patient group. Lastly, we demonstrate the analysis to be robust to camera
type, image format, and resolution.
Conclusions: We developed software that automatically locates and quantifies
disc pallor in fundus photographs and found associations between pallor
measurements and pRNFL thickness.
Translational relevance: We think our method will be useful for the
identification, monitoring and progression of diseases characterized by disc
pallor/optic atrophy, including glaucoma, compression, and potentially in
neurodegenerative disorders.Comment: 44 pages, 20 figures, 7 tables, submitte
Managing healthcare budgets in times of austerity: the role of program budgeting and marginal analysis
Given limited resources, priority setting or choice making will remain a reality at all levels of publicly funded healthcare across countries for many years to come. The pressures may well be even more acute as the impact of the economic crisis of 2008 continues to play out but, even as economies begin to turn around, resources within healthcare will be limited, thus some form of rationing will be required. Over the last few decades, research on healthcare priority setting has focused on methods of implementation as well as on the development of approaches related to fairness and legitimacy and on more technical aspects of decision making including the use of multi-criteria decision analysis. Recently, research has led to better understanding of evaluating priority setting activity including defining ‘success’ and articulating key elements for high performance. This body of research, however, often goes untapped by those charged with making challenging decisions and as such, in line with prevailing public sector incentives, decisions are often reliant on historical allocation patterns and/or political negotiation. These archaic and ineffective approaches not only lead to poor decisions in terms of value for money but further do not reflect basic ethical conditions that can lead to fairness in the decision-making process. The purpose of this paper is to outline a comprehensive approach to priority setting and resource allocation that has been used in different contexts across countries. This will provide decision makers with a single point of access for a basic understanding of relevant tools when faced with having to make difficult decisions about what healthcare services to fund and what not to fund. The paper also addresses several key issues related to priority setting including how health technology assessments can be used, how performance can be improved at a practical level, and what ongoing resource management practice should look like. In terms of future research, one of the most important areas of priority setting that needs further attention is how best to engage public members
Exposure and impact of a mass media campaign targeting sexual health amongst Scottish men who have sex with men: an outcome evaluation
Background:
This paper explores the exposure and impact of a Scottish mass media campaign: Make Your Position Clear. It ran from October 2009 to July 2010, targeted gay men and other men who have sex with men (MSM), and had two key aims: to promote regular sexual health and HIV testing every 6 months, and to promote the use of appropriate condoms and water-based lubricant with each episode of anal intercourse.
Methods: A cross-sectional survey (anonymous and self-report) was conducted 10 months after the campaign was launched (July 2010). Men were recruited from commercial venues. Outcome measures included use of lubricant, testing for sexually transmitted infections and HIV, and intentions to seek HIV testing within the following six months. Linear-by-linear chi-square analysis and binary logistic regressions were conducted to explore the associations between the outcome measures and campaign exposure.
Results:
The total sample was 822 men (62.6% response rate). Men self-identifying as HIV positive were excluded from the analysis (n = 38). Binary logistic analysis indicated that those with mid or high campaign exposure were more likely to have been tested for HIV in the previous six months when adjusted for age, area of residence and use of the “gay scene” (AOR = 1.96, 95% CI = 1.26 to 3.06, p = .003), but were not more likely to be tested for STIs (AOR = 1.37, 95% CI = 0.88 to 2.16, p = .167). When adjusted for previous HIV testing, those with mid or high campaign exposure were not more likely to indicate intention to be tested for HIV in the following six months (AOR = 1.30, 95% CI = 0.73 to 2.32, p = .367). Those with no campaign exposure were less likely than those with low exposure to have used appropriate lubricant with anal sex partners in the previous year (AOR = 0.42, 95% CI = 0.23 to 0.77, p = .005).
Conclusions:
The campaign had demonstrable reach. The analysis showed partial support for the role of mass media campaigns in improving sexual health outcomes. This suggests that a role for mass media campaigns remains within combination HIV prevention
Hide and seek: The theory of mind of visual concealment and search
Researchers have investigated visual search behavior for almost a century. During that time, few studies have examined the cognitive processes involved in hiding items rather than finding them. To investigate this, we developed a paradigm that allowed participants to indicate where they would hide (or find) an item that was to be found (or hidden) by a friend or a foe. We found that (i) for friends more than foes, participants selected the pop-out item in the display, and (ii) when the display was homogeneous, they selected nearby and corner items. These behaviors held for both hiding and finding, although hide and find behaviors were not identical. For pop-out displays, decision times were unusually long when hiding an item from a foe. These data converge on the conclusion that the principles of search and concealment are similar, but not the same. They also suggest that this paradigm will provide researchers a powerful method for investigating theory of mind in adults
Singlet Portal to the Hidden Sector
Ultraviolet physics typically induces a kinetic mixing between gauge singlets
which is marginal and hence non-decoupling in the infrared. In singlet
extensions of the minimal supersymmetric standard model, e.g. the
next-to-minimal supersymmetric standard model, this furnishes a well motivated
and distinctive portal connecting the visible sector to any hidden sector which
contains a singlet chiral superfield. In the presence of singlet kinetic
mixing, the hidden sector automatically acquires a light mass scale in the
range 0.1 - 100 GeV induced by electroweak symmetry breaking. In theories with
R-parity conservation, superparticles produced at the LHC invariably cascade
decay into hidden sector particles. Since the hidden sector singlet couples to
the visible sector via the Higgs sector, these cascades necessarily produce a
Higgs boson in an order 0.01 - 1 fraction of events. Furthermore,
supersymmetric cascades typically produce highly boosted, low-mass hidden
sector singlets decaying visibly, albeit with displacement, into the heaviest
standard model particles which are kinematically accessible. We study
experimental constraints on this broad class of theories, as well as the role
of singlet kinetic mixing in direct detection of hidden sector dark matter. We
also present related theories in which a hidden sector singlet interacts with
the visible sector through kinetic mixing with right-handed neutrinos.Comment: 12 pages, 5 figure
Communication style and exercise compliance in physiotherapy (CONNECT). A cluster randomized controlled trial to test a theory-based intervention to increase chronic low back pain patients’ adherence to physiotherapists’ recommendations: study rationale, design, and methods
Physical activity and exercise therapy are among the accepted clinical rehabilitation guidelines and are recommended self-management strategies for chronic low back pain. However, many back pain sufferers do not adhere to their physiotherapist’s recommendations. Poor patient adherence may decrease the effectiveness of advice and home-based rehabilitation exercises. According to self-determination theory, support from health care practitioners can promote patients’ autonomous motivation and greater long-term behavioral persistence (e.g., adherence to physiotherapists’ recommendations). The aim of this trial is to assess the effect of an intervention designed to increase physiotherapists’ autonomy-supportive communication on low back pain patients’ adherence to physical activity and exercise therapy recommendations. \ud
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This study will be a single-blinded cluster randomized controlled trial. Outpatient physiotherapy centers (N =12) in Dublin, Ireland (population = 1.25 million) will be randomly assigned using a computer-generated algorithm to either the experimental or control arm. Physiotherapists in the experimental arm (two hospitals and four primary care clinics) will attend eight hours of communication skills training. Training will include handouts, workbooks, video examples, role-play, and discussion designed to teach physiotherapists how to communicate in a manner that promotes autonomous patient motivation. Physiotherapists in the waitlist control arm (two hospitals and four primary care clinics) will not receive this training. Participants (N = 292) with chronic low back pain will complete assessments at baseline, as well as 1 week, 4 weeks, 12 weeks, and 24 weeks after their first physiotherapy appointment. Primary outcomes will include adherence to physiotherapy recommendations, as well as low back pain, function, and well-being. Participants will be blinded to treatment allocation, as they will not be told if their physiotherapist has received the communication skills training. Outcome assessors will also be blinded. \ud
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We will use linear mixed modeling to test between arm differences both in the mean levels and the rates of change of the outcome variables. We will employ structural equation modeling to examine the process of change, including hypothesized mediation effects. \ud
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This trial will be the first to test the effect of a self-determination theory-based communication skills training program for physiotherapists on their low back pain patients’ adherence to rehabilitation recommendations. Current Controlled Trials ISRCTN63723433\u
Direct Mediation and Metastable Supersymmetry Breaking for SO(10)
We examine a metastable Macroscopic SO(N) SQCD model of
Intriligator, Seiberg and Shih (ISS). We introduce various baryon and meson
deformations, including multitrace operators and explore embedding an SO(10)
parent of the standard model into two weakly gauged flavour sectors. Direct
fundamental messengers and the symmetric pseudo-modulus messenger mediate SUSY
breaking to the MSSM. Gaugino and sfermion masses are computed and compared for
each deformation type. We also explore reducing the rank of the magnetic quark
matrix of the ISS model and find an additional fundamental messenger.Comment: 43 pages, Latex. Version to appear in JHEP
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