2,634 research outputs found
Mechanistically informed predictions of binding modes for carbocation intermediates of a sesquiterpene synthase reaction.
Sesquiterpenoids comprise a class of terpenoid natural products with thousands of compounds that are highly diverse in structure, generally containing a polycyclic carbon backbone that is constructed by a sesquiterpene synthase. Decades of experimental and computational studies have demonstrated that these enzymes generate a carbocation in the active site, which undergoes a series of structural rearrangements until a product is formed via deprotonation or nucleophile attack. However, for the vast majority of these enzymes the productive binding orientation of the intermediate carbocations has remained unclear. In this work, a method that combines quantum mechanics and computational docking is used to generate an all-atom model of every putative intermediate formed in the context of the enzyme active site for tobacco epi-aristolochene synthase (TEAS). This method identifies a single pathway that links the first intermediate to the last, enabling us to propose the first high-resolution model for the reaction intermediates in the active site of TEAS, and providing testable predictions
Variant supercurrent multiplets
In N = 1 rigid supersymmetric theories, there exist three standard
realizations of the supercurrent multiplet corresponding to the (i) old
minimal, (ii) new minimal and (iii) non-minimal off-shell formulations for N =
1 supergravity. Recently, Komargodski and Seiberg in arXiv:1002.2228 put
forward a new supercurrent and proved its consistency, although in the past it
was believed not to exist. In this paper, three new variant supercurrent
multiplets are proposed. Implications for supergravity-matter systems are
discussed.Comment: 11 pages; V2: minor changes in sect. 3; V3: published version; V4:
typos in eq. (2.3) corrected; V5: comments and references adde
N=2 supergravity and supercurrents
We address the problem of classifying all N=2 supercurrent multiplets in four
space-time dimensions. For this purpose we consider the minimal formulation of
N=2 Poincare supergravity with a tensor compensator, and derive its linearized
action in terms of three N=2 off-shell multiplets: an unconstrained scalar
superfield, a vector multiplet, and a tensor multiplet. Such an action was
ruled out to exist in the past. Using the action constructed, one can derive
other models for linearized N=2 supergravity by applying N=2 superfield duality
transformations. The action depends parametrically on a constant non-vanishing
real isotriplet g^{ij}=g^{ji} which originates as an expectation value of the
tensor compensator. Upon reduction to N=1 superfields, we show that the model
describes two dually equivalent formulations for the massless multiplet
(1,3/2)+(3/2,2) depending on a choice of g^{ij}. In the case g^{11}=g^{22}=0,
the action describes (i) new minimal N=1 supergravity; and (ii) the
Fradkin-Vasiliev-de Wit-van Holten gravitino multiplet. In the case g^{12}=0,
on the other hand, the action describes (i) old minimal N=1 supergravity; and
(ii) the Ogievetsky-Sokatchev gravitino multiplet.Comment: 40 pages; v2: added references, some comments, new appendi
Six-dimensional Supergravity and Projective Superfields
We propose a superspace formulation of N=(1,0) conformal supergravity in six
dimensions. The corresponding superspace constraints are invariant under
super-Weyl transformations generated by a real scalar parameter. The known
variant Weyl super-multiplet is recovered by coupling the geometry to a
super-3-form tensor multiplet. Isotwistor variables are introduced and used to
define projective superfields. We formulate a locally supersymmetric and
super-Weyl invariant action principle in projective superspace. Some families
of dynamical supergravity-matter systems are presented.Comment: 39 pages; v3: some modifications in section 2; equations (2.3),
(2.14b), (2.16) and (2.17) correcte
Pure spinor superfields -- an overview
Maximally supersymmetric theories do not allow off-shell superspace
formulations with traditional superfields containing a finite set of auxiliary
fields. It has become clear that off-shell supersymmetric action formulations
of such models can be achieved by the introduction of pure spinors. In this
talk, an overview of this formalism is given, with emphasis on D=10
super-Yang-Mills theory and D=11 supergravity. This a somewhat expanded version
of a talk presented at the workshop "Breaking of supersymmetry and ultraviolet
divergences in extended supergravity" (BUDS), Laboratori Nazionali di Frascati,
March 25-28, 2013.Comment: 34 pp., 2 figs., contributions to the proceedings of the workshop
"Breaking of supersymmetry and ultraviolet divergences in extended
supergravity" (BUDS), Laboratori Nazionali di Frascati, March 25-28, 201
Comments on Supercurrent Multiplets, Supersymmetric Field Theories and Supergravity
We analyze various supersymmetry multiplets containing the supercurrent and
the energy-momentum tensor. The most widely known such multiplet, the
Ferrara-Zumino (FZ) multiplet, is not always well-defined. This can happen once
Fayet-Iliopoulos (FI) terms are present or when the Kahler form of the target
space is not exact. We present a new multiplet S which always exists. This
understanding of the supersymmetry current allows us to obtain new results
about the possible IR behavior of supersymmetric theories. Next, we discuss the
coupling of rigid supersymmetric theories to supergravity. When the theory has
an FZ-multiplet or it has a global R-symmetry the standard formalism can be
used. But when this is not the case such simple gauging is impossible. Then, we
must gauge the current S. The resulting theory has, in addition to the graviton
and the gravitino, another massless chiral superfield Phi which is essential
for the consistency of the theory. Some of the moduli of various string models
play the role of Phi. Our general considerations, which are based on the
consistency of supergravity, show that such moduli cannot be easily lifted thus
leading to constraints on gravity/string models.Comment: 27 pages. v2: references added and minor changes. v3: minor changes.
v4: minor clarification
N = 2 supersymmetric sigma-models and duality
For two families of four-dimensional off-shell N = 2 supersymmetric nonlinear
sigma-models constructed originally in projective superspace, we develop their
formulation in terms of N = 1 chiral superfields. Specifically, these theories
are: (i) sigma-models on cotangent bundles T*M of arbitrary real analytic
Kaehler manifolds M; (ii) general superconformal sigma-models described by
weight-one polar supermultiplets. Using superspace techniques, we obtain a
universal expression for the holomorphic symplectic two-form \omega^{(2,0)}
which determines the second supersymmetry transformation and is associated with
the two complex structures of the hyperkaehler space T*M that are complimentary
to the one induced from M. This two-form is shown to coincide with the
canonical holomorphic symplectic structure. In the case (ii), we demonstrate
that \omega^{(2,0)} and the homothetic conformal Killing vector determine the
explicit form of the superconformal transformations. At the heart of our
construction is the duality (generalized Legendre transform) between off-shell
N = 2 supersymmetric nonlinear sigma-models and their on-shell N = 1 chiral
realizations. We finally present the most general N = 2 superconformal
nonlinear sigma-model formulated in terms of N = 1 chiral superfields. The
approach developed can naturally be generalized in order to describe 5D and 6D
superconformal nonlinear sigma-models in 4D N = 1 superspace.Comment: 31 pages, no figures; V2: reference and comments added, typos
corrected; V3: more typos corrected, published versio
On Topologically Massive Spin-2 Gauge Theories beyond Three Dimensions
We investigate in which sense, at the linearized level, one can extend the 3D
topologically massive gravity theory beyond three dimensions. We show that, for
each k=1,2,3... a free topologically massive gauge theory in 4k-1 dimensions
can be defined describing a massive "spin-2" particle provided one uses a
non-standard representation of the massive "spin-2" state which makes use of a
two-column Young tableau where each column is of height 2k-1. We work out the
case of k=2, i.e. 7D, and show, by canonical analysis, that the model
describes, unitarily, 35 massive "spin-2" degrees of freedom. The issue of
interactions is discussed and compared with the three-dimensional situation.Comment: 14 pages. v2: minor changes - published versio
The linear multiplet and ectoplasm
In the framework of the superconformal tensor calculus for 4D N=2
supergravity, locally supersymmetric actions are often constructed using the
linear multiplet. We provide a superform formulation for the linear multiplet
and derive the corresponding action functional using the ectoplasm method (also
known as the superform approach to the construction of supersymmetric
invariants). We propose a new locally supersymmetric action which makes use of
a deformed linear multiplet. The novel feature of this multiplet is that it
corresponds to the case of a gauged central charge using a one-form potential
not annihilated by the central charge (unlike the standard N=2 vector
multiplet). Such a gauge one-form can be chosen to describe a variant nonlinear
vector-tensor multiplet. As a byproduct of our construction, we also find a
variant realization of the tensor multiplet in supergravity where one of the
auxiliaries is replaced by the field strength of a gauge three-form.Comment: 31 pages; v3: minor corrections and typos fixed, version to appear in
JHE
Towards Field Theory Amplitudes From the Cohomology of Pure Spinor Superspace
A simple BRST-closed expression for the color-ordered super-Yang-Mills
5-point amplitude at tree-level is proposed in pure spinor superspace and shown
to be BRST-equivalent to the field theory limit of the open superstring 5-pt
amplitude. It is manifestly cyclic invariant and each one of its five terms can
be associated to the five Feynman diagrams which use only cubic vertices. Its
form also suggests an empirical method to find superspace expressions in the
cohomology of the pure spinor BRST operator for higher-point amplitudes based
on their kinematic pole structure. Using this method, Ansaetze for the 6- and
7-point 10D super-Yang-Mills amplitudes which map to their 14 and 42
color-ordered diagrams are conjectured and their 6- and 7-gluon expansions are
explicitly computed.Comment: 14 pages, harvmac, v4: trivial edits in the text to comply with JHEP
refere
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