2,071 research outputs found
Cavity cooling of a single atom
All conventional methods to laser-cool atoms rely on repeated cycles of
optical pumping and spontaneous emission of a photon by the atom. Spontaneous
emission in a random direction is the dissipative mechanism required to remove
entropy from the atom. However, alternative cooling methods have been proposed
for a single atom strongly coupled to a high-finesse cavity; the role of
spontaneous emission is replaced by the escape of a photon from the cavity.
Application of such cooling schemes would improve the performance of atom
cavity systems for quantum information processing. Furthermore, as cavity
cooling does not rely on spontaneous emission, it can be applied to systems
that cannot be laser-cooled by conventional methods; these include molecules
(which do not have a closed transition) and collective excitations of Bose
condensates, which are destroyed by randomly directed recoil kicks. Here we
demonstrate cavity cooling of single rubidium atoms stored in an intracavity
dipole trap. The cooling mechanism results in extended storage times and
improved localization of atoms. We estimate that the observed cooling rate is
at least five times larger than that produced by free-space cooling methods,
for comparable excitation of the atom
Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the R6/2 Mouse Model of HD
Huntington's disease (HD) is caused by the expansion of a CAG repeat in the huntingtin (HTT) gene. The R6/2 mouse model of HD expresses a mutant version of exon 1 HTT and develops motor and cognitive impairments, a widespread huntingtin (HTT) aggregate pathology and brain atrophy. Despite the vast number of studies that have been performed on this model, the association between the molecular and cellular neuropathology with brain atrophy, and with the development of behavioral phenotypes remains poorly understood. In an attempt to link these factors, we have performed longitudinal assessments of behavior (rotarod, open field, passive avoidance) and of regional brain abnormalities determined through magnetic resonance imaging (MRI) (whole brain, striatum, cortex, hippocampus, corpus callosum), as well as an end-stage histological assessment. Detailed correlative analyses of these three measures were then performed. We found a gender-dependent emergence of motor impairments that was associated with an age-related loss of regional brain volumes. MRI measurements further indicated that there was no striatal atrophy, but rather a lack of striatal growth beyond 8 weeks of age. T2 relaxivity further indicated tissue-level changes within brain regions. Despite these dramatic motor and neuroanatomical abnormalities, R6/2 mice did not exhibit neuronal loss in the striatum or motor cortex, although there was a significant increase in neuronal density due to tissue atrophy. The deposition of the mutant HTT (mHTT) protein, the hallmark of HD molecular pathology, was widely distributed throughout the brain. End-stage histopathological assessments were not found to be as robustly correlated with the longitudinal measures of brain atrophy or motor impairments. In conclusion, modeling pre-manifest and early progression of the disease in more slowly progressing animal models will be key to establishing which changes are causally related. © 2013 Rattray et al
Single donor ionization energies in a nanoscale CMOS channel
One consequence of the continued downwards scaling of transistors is the
reliance on only a few discrete atoms to dope the channel, and random
fluctuations of the number of these dopants is already a major issue in the
microelectonics industry. While single-dopant signatures have been observed at
low temperature, studying the impact of only one dopant up to room temperature
requires extremely small lengths. Here, we show that a single arsenic dopant
dramatically affects the off-state behavior of an advanced microelectronics
field effect transistor (FET) at room temperature. Furthermore, the ionization
energy of this dopant should be profoundly modified by the close proximity of
materials with a different dielectric constant than the host semiconductor. We
measure a strong enhancement, from 54meV to 108meV, of the ionization energy of
an arsenic atom located near the buried oxide. This enhancement is responsible
for the large current below threshold at room temperature and therefore
explains the large variability in these ultra-scaled transistors. The results
also suggest a path to incorporating quantum functionalities into silicon CMOS
devices through manipulation of single donor orbitals
Holocene deglaciation and glacier readvances on the Fildes Peninsula and King George Island (Isla 25 de Mayo), South Shetland Islands, NW Antarctic Peninsula
To provide insights into glacier-climate dynamics of the South Shetland Islands (SSI), NW Antarctic Peninsula, we present a new deglaciation and readvance model for the Bellingshausen Ice Cap (BIC) on Fildes Peninsula and for King George Island/Isla 25 de Mayo (KGI) ~62°S. Deglaciation on KGI began after c. 15 ka cal BP and had progressed to within present-day limits on the Fildes Peninsula, its largest ice-free peninsula, by c. 6.6â5.3 ka cal BP. Probability density phase analysis of chronological data constraining Holocene glacier advances on KGI revealed up to eight 95% probability âgapsâ during which readvances could have occurred. These are grouped into four stages â Stage 1: a readvance and marine transgression, well-constrained by field data, between c. 7.4â6.6 ka cal BP; Stage 2: four probability âgapsâ, less well-constrained by field data, between c. 5.3â2.2 ka cal BP; Stage 3: a well-constrained but restricted âreadvanceâ between c. 1.7â1.5 ka; Stage 4: two further minor âreadvancesâ, one less well-constrained by field data between c. 1.3â0.7 ka cal BP (68% probability), and a âfinalâ well-constrained âreadvanceâ after 1950 CE) is associated with recent warming/more positive SAM-like conditions
New distance measures for classifying X-ray astronomy data into stellar classes
The classification of the X-ray sources into classes (such as extragalactic
sources, background stars, ...) is an essential task in astronomy. Typically,
one of the classes corresponds to extragalactic radiation, whose photon
emission behaviour is well characterized by a homogeneous Poisson process. We
propose to use normalized versions of the Wasserstein and Zolotarev distances
to quantify the deviation of the distribution of photon interarrival times from
the exponential class. Our main motivation is the analysis of a massive dataset
from X-ray astronomy obtained by the Chandra Orion Ultradeep Project (COUP).
This project yielded a large catalog of 1616 X-ray cosmic sources in the Orion
Nebula region, with their series of photon arrival times and associated
energies. We consider the plug-in estimators of these metrics, determine their
asymptotic distributions, and illustrate their finite-sample performance with a
Monte Carlo study. We estimate these metrics for each COUP source from three
different classes. We conclude that our proposal provides a striking amount of
information on the nature of the photon emitting sources. Further, these
variables have the ability to identify X-ray sources wrongly catalogued before.
As an appealing conclusion, we show that some sources, previously classified as
extragalactic emissions, have a much higher probability of being young stars in
Orion Nebula.Comment: 29 page
Predictions from Heavy New Physics Interpretation of the Top Forward-Backward Asymmetry
We derive generic predictions at hadron colliders from the large
forward-backward asymmetry observed at the Tevatron, assuming the latter arises
from heavy new physics beyond the Standard Model. We use an effective field
theory approach to characterize the associated unknown dynamics. By fitting the
Tevatron t \bar t data we derive constraints on the form of the new physics.
Furthermore, we show that heavy new physics explaining the Tevatron data
generically enhances at high invariant masses both the top pair production
cross section and the charge asymmetry at the LHC. This enhancement can be
within the sensitivity of the 8 TeV run, such that the 2012 LHC data should be
able to exclude a large class of models of heavy new physics or provide hints
for its presence. The same new physics implies a contribution to the
forward-backward asymmetry in bottom pair production at low invariant masses of
order a permil at most.Comment: 11 pages, 6 figures. v2: added remarks on EFT validity range, dijet
bounds and UV completions; matches published versio
Elementary Forms of the Metaphorical Life : Tropes at Work in Durkheimâs Theory of the Religious
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