1,488 research outputs found
Particle-in-cell simulations of shock-driven reconnection in relativistic striped winds
By means of two- and three-dimensional particle-in-cell simulations, we
investigate the process of driven magnetic reconnection at the termination
shock of relativistic striped flows. In pulsar winds and in magnetar-powered
relativistic jets, the flow consists of stripes of alternating magnetic field
polarity, separated by current sheets of hot plasma. At the wind termination
shock, the flow compresses and the alternating fields annihilate by driven
magnetic reconnection. Irrespective of the stripe wavelength "lambda" or the
wind magnetization "sigma" (in the regime sigma>>1 of magnetically-dominated
flows), shock-driven reconnection transfers all the magnetic energy of
alternating fields to the particles, whose average Lorentz factor increases by
a factor of sigma with respect to the pre-shock value. In the limit
lambda/(r_L*sigma)>>1, where r_L is the relativistic Larmor radius in the wind,
the post-shock particle spectrum approaches a flat power-law tail with slope
around -1.5, populated by particles accelerated by the reconnection electric
field. The presence of a current-aligned "guide" magnetic field suppresses the
acceleration of particles only when the guide field is stronger than the
alternating component. Our findings place important constraints on the models
of non-thermal radiation from Pulsar Wind Nebulae and relativistic jets.Comment: 25 pages, 14 figures, movies available at
https://www.cfa.harvard.edu/~lsironi/sironi_movies.tar ; in press, special
issue of Computational Science and Discovery on selected research from the
22nd International Conference on Numerical Simulation of Plasma
Effects of creatine treatment on Jejunal phenotypes in a rat model of acidosis
We investigated the effects of creatine treatment on jejunal phenotypes in a rat model of oxidative stress induced by acidosis. In particular, the activities of some antioxidant enzymes (superoxide dismutase, glutathione peroxidase, catalase, and glutathione reductase), the level of lipid peroxidation, the expression of heat shock proteins (HSP70), and the expression of the major carriers of the cells (Na+/K+-ATPase, sodium-glucose Transporter 1\u2014SGLT1, and glucose transporter 2\u2014GLUT2) were measured under control and chronic acidosis conditions. Creatine did not affect the activity of antioxidant enzymes in either the control or acidosis groups, except for catalase, for which the activity was reduced in both conditions. Creatine did not change the lipid peroxidation level or HSP70 expression. Finally, creatine stimulated (Na+/K+)-ATPase expression under both control and chronic acidosis conditions. Chronic acidosis caused reductions in the expression levels of GLUT2 and SGLT1. GLUT2 reduction was abolished by creatine, while the presence of creatine did not induce any strengthening effect on the expression of SGLT1 in either the control or chronic acidosis groups. These results indicate that creatine has antioxidant properties that are realized through direct interaction of the molecule with reactive oxygen species. Moreover, the administration of creatine seems to determine a functional strengthening of the tissue, making it more resistant to acidosis
Particle Acceleration in Pulsar Wind Nebulae: PIC modelling
We discuss the role of particle-in-cell (PIC) simulations in unveiling the
origin of the emitting particles in PWNe. After describing the basics of the
PIC technique, we summarize its implications for the quiescent and the flaring
emission of the Crab Nebula, as a prototype of PWNe. A consensus seems to be
emerging that, in addition to the standard scenario of particle acceleration
via the Fermi process at the termination shock of the pulsar wind, magnetic
reconnection in the wind, at the termination shock and in the Nebula plays a
major role in powering the multi-wavelength signatures of PWNe.Comment: 32 pages, 16 figures, to appear in the book "Modelling Nebulae"
edited by D. Torres for Springer, based on the invited contributions to the
workshop held in Sant Cugat (Barcelona), June 14-17, 201
First optical validation of a Schwarzschild Couder telescope: the ASTRI SST-2M Cherenkov telescope
The Cherenkov Telescope Array (CTA) represents the most advanced facility
designed for Cherenkov Astronomy. ASTRI SST-2M has been developed as a
demonstrator for the Small Size Telescope in the context of the upcoming CTA.
Its main innovation consists in the optical layout which implements the
Schwarzschild-Couder configuration and is fully validated for the first time.
The ASTRI SST-2M optical system represents the first qualified example for two
mirrors telescope for Cherenkov Astronomy.
This configuration permits to (i) maintain a high optical quality across a
large FoV (ii) de-magnify the plate scale, (iii) exploit new technological
solutions for focal plane sensors. The goal of the paper is to present the
optical qualification of the ASTRI SST-2M telescope. The qualification has been
obtained measuring the PSF sizes generated in the focal plane at various
distance from the optical axis. These values have been compared with the
performances expected by design.
After an introduction on the Gamma Astronomy from the ground, the optical
design and how it has been implemented for ASTRI SST-2M is discussed. Moreover
the description of the setup used to qualify the telescope over the full field
of view is shown.
We report the results of the first--light optical qualification. The required
specification of a flat PSF of arcmin in a large field of view ~10
deg has been demonstrated. These results validate the design specifications,
opening a new scenario for Cherenkov Gamma ray Astronomy and, in particular,
for the detection of high energy (5 - 300 TeV) gamma rays and wide-field
observations with CTA.Comment: 6 pages, 5 figure
TRIS II: search for CMB spectral distortions at 0.60, 0.82 and 2.5 GHz
With the TRIS experiment we have performed absolute measurements of the sky
brightness in a sky circle at at the frequencies
0.60, 0.82 and 2.5 GHz. In this paper we discuss the techniques used to
separate the different contributions to the sky emission and give an evaluation
of the absolute temperature of the Cosmic Microwave Background. For the
black-body temperature of the CMB we get: at GHz; at GHz; at
GHz. The first error bar is statistic (1) while the second
one is systematic. These results represent a significant improvement with
respect to the previous measurements. We have also set new limits to the
free-free distortions, ,
and slightly improved the Bose-Einstein upper limit, , both at 95% confidence level.Comment: accepted for publication in The Astrophysical Journa
single nucleotide polymorphism discovery in the avian tapasin gene
Abstract Tapasin is a transmembrane glycoprotein located in the endoplasmic reticulum. Its function is to assist the assembly of major histocompatibility complex class I molecules. The chicken Tapasin gene includes 8 exons and is localized inside the major histocompatibility complex between the 2 class IIβ genes. The aim of the current study was the estimation of single nucleotide polymorphism frequency within the avian Tapasin gene. The Tapasin gene sequence from exon 5 to exon 6 was amplified for the chicken, turkey, and pheasant, and sequences of different lengths were obtained. The sequence analysis based on PolyBayes identified 25 putative single nucleotide polymorphism sites when the 3 species were compared. The coding sequences were further translated and analyzed to identify amino acid substitutions. The results indicated that polymorphisms within this region of the gene was mainly observed in the heterozygous state. The level of conservation of the Tapasin gene sequence among species is likely to be related to the functional importance of the gene
Bleaching melanin in formalin-fixed and paraffin-embedded melanoma specimens using visible light : a pilot study
In fluorescence microscopy, light radiation can be used to bleach fluorescent
molecules in formalin-fixed and paraffin-embedded (FFPE) samples, in order to
increase the ratio between signal of interest and background autofluorescence. We
tested if the same principle can be exploited in bright field microscopy to
bleach pigmented melanoma FFPE sections together with cell morphology
maintenance. After dewaxing and rehydration, serial FFPE sections of a feline
diffuse iris melanoma, a canine dermal melanoma, a gray horse dermal melanoma and
a swine cutaneous melanoma were irradiated with visible light for 1, 2, 3, 4 and
5 days, prior to Hematoxylin and Eosin staining. Complete bleaching was obtained
after 1-day treatment in feline and swine melanomas, while 2 and 3 days were
required in canine and equine neoplasms, respectively. In all treated samples,
cell morphology was maintained. Photo-induced bleaching combined with
immunohistochemistry was tested after a 3-day photo-treatment using five
different markers. According to the literature, in all samples neoplastic cells
stained positive for vimentin, S100 and PNL2, while negative for FVIII and
pancytokeratin. In conclusion, visible light can be effectively exploited to
bleach pigmented melanoma FFPE sections prior to perform routine histochemical
and immunohistochemical stains
- …