A study to assess Vitamin D deficiency and its association with sepsis in tertiary care centre

Introduction : Sepsis is a life threatening organ dysfunction generated due to the dysregulation of the immune response to infection. A high mortality rate in sepsis is the result of multiple organ failure which often follows sepsis. Recent studies have shown the correlation between vitamin D deficiency and severe infections and sepsis Aim and objective : To evaluate the correlation between serum levels of vitamin D and outcome of sepsis patients presenting to ED. Methodology : This cross sectional study was performed in the Saraswathi institute of medical sciences, Hapur from October 2021 to March 2022. For all the eligible patients, blood sample was drawn for measuring serum level of vitamin D and finally the correlation between the level of this vitamin and the studied outcomes was evaluated. Result : The mean vit d level of the study subjects who get cured were 23.09±11.20, whereas those patients who died had vit d level 16.12±10.60, on comparing there is significant association of vit d level with outcome of study subjects, with p value 0.02. On assessing  vit D level with TLC of study subjects, on applying regression analysis we found no correlation between vitd level and TLC value of the study subjects with R square 0.   Conclusion : On the basis of our study we can conclude that There is significant association of serum vit d level with outcome of sepsis in the study subjects. On comparing there is significant association of vit d level with outcome of study subjects, with p value 0.02, CRP increases generally in infections, it was associated with vit D level, however association was statistically non-significant

Usage Summary of Institute of Physics Publishing e-Journals from Jan 2015 to May 2018: A Study of Dr. Bhim Rao Ambedkar Library, Guru Jambheshwar University of Science &Technology Hisar-125 001, Haryana - India

Abstract Purpose- Since inception e-journals have proved mile stone in the history of the research and academics. Undoubtedly, after emerging e-resources the research activities got new pace and new dimension particularly in higher educational institutions especially since last two decades. No issue of physical distance with e-journals as these may be accessible from any corner of the world without doing physical efforts even available in abundance on single platform and access with single click. Moreover, anyone can download the same, store and keep safe for existing and budding scholars without occupying the physical space. In addition, in fraction of seconds, the information may be exchanged and spread all over the world. It won’t be an exaggeration to say that the data from e-journals may be searched without beginning and without ending. The paper aims to extract the information from its usages log book (from January 2015 to May 2018) that how much use of this product which shall help to take decision for its further renewal. Methodology- Secondary data has been used. The summary of usages has been demanded from the product vendor’s. After receiving the usages summary, the data has been analyzed and whatever was valued for my proposed study, the same has been incorporated in the paper. Findings- After analyzing the usages summary data revealed that the users are more concerned with the current issues and retrieve of information from archive is very less. The same finding shall help to take decision whatever can be subscribed for their scholars; thereby funds burden may be released. Originality/value- This attempt surely helpful to those institutes whom funds availability is underprivileged. In fact Guru Jambheshwar University Science & Technology can take decision for its further renewal according to its usages as findings shown that the current issues are in more use instead of archive

MACROSCOPIC IDENTIFICATION OF CRUDE DRUGS FOR AYURVEDIC FORMULATIONS

There are certain diseases in which western medicines are still lacking cure. It is important to note that western medicine is undoubtedly effective for symptomatic control of these disorders but still lacking cure for potential. Apart from this these drugs are having numerous side effects. Keeping this fact in mind the attention diverts towards our ancient system of medicine i.e Ayurveda for radical cure of these diseases. The demand for plant derived products is increasing day by day. For preparation of any Ayurvedic formulation proper identification of crude drug is extremely necessary. Identification of crude drug involves the morphological or macroscopic details and microscopic parameters. These parameters are necessary for the preparation of accurate and potent formulations. Identification of crude drug is the most important step in development of standards for herbal drugs a lot of adulteration is being done. The major problems affecting the quality of crude drug are adulteration or substitution, degradation due to faulty collections, drying or storage. A well known example is of drug Ashoka which is the stem bark of Saraca indica, the material available in the market is frequently found to be Polyalthia longifolia

IDENTIFICATION OF PUM KUTAJA AND STRI KUTAJA MENTIONED IN THE AYURVEDIC LITERATURE

Kutaja is one among the frequently used medicinal plants in Ayurveda. Kutaja is the drug of choice for bleeding piles. Acharya Charak quoted Kutaja tvak as the best Sangrahika dravya. It possess properties like Deepana and Pachana and is useful in the management of diarrhoea. Charak enumerated eighteen yogas of Kutaja with the name Vatsaka in Kalpasthana. In this context he described male and female varieties of Kutaja. Modern experts have also described two varieties of Kutaja i.e., Sveta and Krishna variety. The bark and seeds of Kutaja are used for different medicinal purposes. The seeds of Sveta Kutaja and the seeds which are Tikta, possess better medicinal property. The market sample comprises of seeds of both Tikta and Madhur variety mixed together. Market sample of Kutaja mostly comprises of Madhur seeds. There are three species taken under the name of Kutaja i.e., Holarrhena antidysentrica, Wrightia tomentosa and Wrightia tinctoria. It is a matter of confusion that which one is to be taken as Pum Kutaja and which one as Stri Kutaja. This article is to throw some light on different species taken as Kutaja and decide which species should be taken as Pum Kutaja and which one is to be taken as Stri kutaja

MANJISTHA (RUBIA CORDIFOLIA) AS COSMECEUTICAL REMEDY FOR PREVENTION OF STRIAE GRAVIDARUM

Cosmetics have important place in every women's life since ancient times. Women are more concern about their look during pregnancy as 90% cases develop striae marks on abdomen, breast and thighs or scratch marks due to itching make their look ugly. But there is a difference between cosmetic and cosmeceutical products which restrict sell of cosmetic without medical prescription if it contains ingredients that can penetrate or change the functioning of the skin. Cosmeceuticals are serving as a bridge between personal care products and pharmaceuticals. Manjistha can play a very good role in this burning issue of itching and striae marks due to their medicinal properties. Manjistha as remedy can prevent burning, itching and other fungal or bacterial infection and promotes skin healing by local action on skin and promotes collagen formation due to property of Ropana- Sothahar. Kandughana and Vishghana properties shows antiallergic action, anti bacterial, antifungal action actions prevents skin from secondary infection of skin caused due to itching. Pittashamak property pacify alleviated dosha and Varnya property promotes skin texture, colour and luster. Manjistha can acts as skin protective drug which is used in Striae gravidarum to relief basic symptom of hypopigmentation, itching burning and maintains skin luster so that drug can be used in cosmeceutical industry for prevention of striae gravidarum

A REVIEW - CURCUMA LONGA (HARIDRA): EMERGING AS MAGICAL HERB FROM TRADITIONS TO THE PHARMACEUTICAL INDUSTRIES

Haridra is a potent medicinal herb used traditionally since ancient times for the treatment of various skin disorders, liver disorders and respiratory disorders and are well documented in Ayurvedic literatures. This is again revalidated by recent researches done on the biological and pharmacological actions like anti-inflammatory, antioxidant, anti diabetic, antibacterial, hepatoprotective, expectorant, anti cancerous, anti mutagenic, anti melanogenic, free radical scavenging properties of phytoconstituents of Curcuma longa like curcumin, curcuminoids etc. Due to high potency and therapeutic value of drug its demand is increasing in pharmaceutical industries for preparation of various formulations containing Curcuma longa or its constituents. Cultivation of drug on large scale is done for trading as India is one of the main trading center of Curcuma longa (Indian Saffron) and its various varieties are available in market.This review focuses on these potent pharmacological properties with macroscopic and microscopic features of both cured and uncured available rhizomes of Haridra in market with nutritional value and its wide range of use in cosmeceutical and nutraceutical industry which proves it as arising magical herb in pharmaceutical industry for preparation of formulations used in various diseases

REVIEW OF APAMARGA (ACHYRANTHES ASPERA LINN.) IN VEDIC VAANGMAYA & SAMHITA GRANTHS

Apamarga, a well known herb is found as a weed throughout India. It is important to note that number of herbs gradually increased from Rigveda to Atharvaveda. This very fact indicate towards metamorphosis of a system of medicine which was earlier based on Hymns (mantras) later accepted more and more interventions/ herbal drugs. This trend continued in Samhita period and reached its extreme during Nighantu period. Therefore it is necessary to know about the vedic herbs. Apamarga is one of them. In Atharvaveda it is said to be Kshetriya roga nasak and Yatudhan Krimi nasak. In Yajurveda it is said to be used for hawan purpose due to its Rakshoghna property. No other plant has got better water removing property than Apamarga. It has also got property like Kushthaghna, Paaproga nasak, Duhswapnanasana. Apamarga is considered as lord of all plants because it posses hundreds of properties and wipe away all the diseases. In different Ayurvedic treatise it is indicated in Arsha, Kushtha, Unmada, Apasmara, Ashmari, Hikka-Swaas, Vish Chikitsa etc. Traditionally each and every part of the plant is used in different diseases like dysentery, asthma, piles, stomatitis etc. It is also used as anti diabetic, anti inflammatory, abortifacient etc. The present article gives the literary information regarding the different uses of Apamarga in Vedic Vaangmaya and Samhita Granths

IDENTIFICATION OF DIFFERENT VARIETIES OF PUNARNAVA MENTIONED IN THE AYURVEDIC LITERATURE

Punurnava is one of controversial drug in Ayurveda. Nighantus have created a lot of confusion in the identification of different varieties of Punarnava mentioned in the Ayurvedic texts. Majority of the Nighantu used Varshabhu as the synonym of Punarnava. But later studies have proved that the two plants are totally different. In majority of Nighantus two varieties of Punarnava are found i.e Sveta and Rakta. Most of the people think Boerhaavia diffusa to be the red variety and Trianthema portulacastrum to be the white variety. But this is not correct. There are three plants which lie under this two category i.e Boerhaavia diffusa, Boerhaavia verticillata and Trianthema portulacastrum. On the basis of colour White and Red variety are differentiated. But with the colour what is to be taken whether the colour of the stem or the colour of the flowers. Punarnava is one of the very important anti inflammatory medicinal herb. Nowadays it is used for Mutrala as well as for its Rasayana property. Therefore it is need for the identification of correct plant or the species to get the best therapeutic effect of the plant. This article is to find out the correct species, which one is to be taken as Sveta and which one to be taken as Rakta Punarnava

PHARMACOGNOSTICAL EVALUATION OF DIFFERENT PARTS OF APAMARGA (ACHYRANTHES ASPERA LINN.)

Plants continue to serve as possible sources for new drugs and chemicals derived from various parts of plants. Nowadays adulteration of crude herbal drugs is very common due to scarcity of drug and its high price prevailing in the market. These herbal medicines can stand in commercial market only if they are evaluated according to modern science. Evaluation of herb involves confirmation of its identity, determination of its quality and purity, and detection of nature of adulteration. So before utilizing a drug for therapeutic purpose, detail pharmacognostical study is essential as it not only helps in correct identification of the drug but also to get a clue for its phytochemicals, pharmacological activities and medicinal properties. API (Ayurvedic Pharmacopoeia of India) has provided standards for a number of plants. But for Apamarga standards are given only for roots and Panchanga (Whole plant), not for the other parts like seeds, leaf and stems which are also used on a large scale for different medicinal properties. Standards are required to be developed for each and every part of the Apamarga. Genuine samples of different parts of Achyranthes aspera Linn was taken to set the standard for each and every part of Apamarga used for medicinal properties. The collected genuine samples were then subjected to macroscopic, microscopy, physicochemical, phytochemical and chromatographic study. Now a day most of the pharmaceutical companies are dealing with plant extracts and Ayurvedic Vaidyas too prefer using single drug extract instead of multiple drug formulations and are getting great response from the patients.