Association of polymorphisms at the ADIPOR1 regulatory region with type 2 diabetes and body mass index in a Brazilian population with European or African ancestry

Association studies between ADIPOR1 genetic variants and predisposition to type 2 diabetes (DM2) have provided contradictory results. We determined if two single nucleotide polymorphisms (SNP c.-8503G>A and SNP c.10225C>G) in regulatory regions of ADIPOR1 in 567 Brazilian individuals of European (EA; N = 443) or African (AfA; N = 124) ancestry from rural (quilombo remnants; N = 439) and urban (N = 567) areas. We detected a significant effect of ethnicity on the distribution of the allelic frequencies of both SNPs in these populations (EA: -8503A = 0.27; AfA: -8503A = 0.16; P = 0.001 and EA: 10225G = 0.35; AfA: 10225G = 0.51; P < 0.001). Neither of the polymorphisms were associated with DM2 in the case-control study in EA (SNP c.-8503G>A: DM2 group -8503A = 0.26; control group -8503A = 0.30; P = 0.14/SNP 10225C>G: DM2 group 10225G = 0.37; control group 10225G = 0.32; P = 0.40) and AfA populations (SNP c.-8503G>A: DM2 group -8503A = 0.16; control group -8503A = 0.15; P = 0.34/SNP 10225C>G: DM2 group 10225G = 0.51; control group 10225G = 0.52; P = 0.50). Similarly, none of the polymorphisms were associated with metabolic/anthropometric risk factors for DM2 in any of the three populations, except for HDL cholesterol, which was significantly higher in AfA heterozygotes (GC = 53.75 ± 17.26 mg/dL) than in homozygotes. We conclude that ADIPOR1 polymorphisms are unlikely to be major risk factors for DM2 or for metabolic/anthropometric measurements that represent risk factors for DM2 in populations of European and African ancestries.FAPESP 04/0185-5CEPIDHospital de Clínicas de Porto Alegr

Apoptosis in human liver carcinoma caused by gold nanoparticles in combination with carvedilol is mediated via modulation of MAPK/Akt/mTOR pathway and EGFR/FAAD proteins

Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas

Estudos sobre a nutrição mineral do arroz: X. marcha de absorção de micronutrientes pela variedade IAC-25

The uptake of micronutrients (B, Cu, Fe, Mn and Zn) by the variety IAC-25 in various phases of its development was studied, the plants being grown in nutrient solution, Main conclusions were the following: (a) only two variables, namely dry matter production an Fe accumulation, showed a tendency to level off as the plants complete their life cycle; (b) indication of internal redistribution was observed in the case of Fe and Mn; (c) maximum rate of uptake, was well as of dry matter production took place in the period which goes from tillering to grain filling.Em condições controladas estudaram-se: acumulação de micronutrientes e produção de materia seca pela variedade de arroz IAC-25. A curva que descreve a produção de matéria seca total em função do tempo apresentou a tendência a sigmóide. Com respeito a acumulação global de micronutrientes, entretanto, o mesmo foi observado somente no caso do ferro

Estudos sobre a nutrição mineral do arroz: VII. exigências nutricionais das variedades IAC-25 e IAC-47

Rice plants, varieties IAC 25 and IAC 47, were grown in nutrient solution till the end of the life cycle when they were analysed both for macro and micronutrients. Main conclusions were the following: IAC 47, higher yielding, showed larger requirements than IAC 25; for production (total) and export (grain), the demand for nutrients was the same in both varieties.As exigências nutricionais das variedades de arroz IAC 25 e IAC 47 foram determinadas analisando-se os diferentes órgãos de plantas cultivadas em solução nutritiva até o fim do ciclo. Verificou-se serem distintas as exigências, maior na IAC 47 (mais tardia) que deu também maior produção de grãos com casca

Studies on the mineral nutrition of the rice plant: IX. time course on the uptake of macronutrients by the variety IAC-47

Rice plants, variety IAC-47, were grown in the nº 2 nutrient solution of HOAGLAND & ARNON (1950) until the end of the life cycle. Plants were sampled at well defined physiological periods for analyses. It was verified that trends for levvelling off occurred in the case of accumulation of N, K and Ca. Translocation from leaves to grain was observed with respect to N, P and K. Maximum rates of uptake of all elements took place from 50 to 100 days after germination.Foram estudadas, em condições controladas, a acumulação de matéria seca e a de macronutrientes na variedade de arroz IAC-47. Ambos os processos em geral são descritos por sigmóides típicas; picos para os valores totais de produção de matéria seca e de acumulação de elementos entre: 100 e 140 dias depois da germinação

Estudos sobre a nutrição mineral do arroz: XI. Marcha de absorção de micronutrientes pela variedade IAC-47

Dry matter yield and uptake of B, Cu, Fe, Mn and Zn by the rice variety IAC-47 were studied under controlled conditions, namely, by growing plants in nutrient solution and by falcing samples for analyses in set physiological periods. It was observed that only the curves describing dry matter production and accumulation of B and Fe was verified.A produção de matéria seca e a absorção de micronutrientes (B, Cu, Fe, Mn e Zn) pelo arroz var. IAC-47 foram estudadas usando-se plantas cultivadas em solução nutritiva. Verificou-se que: enquanto as curvas que descrevem o crescimento e a acumulação de B e Fe mostram tendência sigmóide, as demais não o fazem, evidência de redistribuição foi observada somente nos casos do B (diminuição no conteúdo foliar) e no do Fe (diminuição no conteúdo da raiz)

Estudos sobre a nutrição mineral do arroz: XIII. efeitos das deficiências de micronutrientes nas variedades IAC-25 e IAC-47

Rice plants were grown in nutrient solution lither in the presence or in the absence of B, Cu and Zn. The symptoms of deficiency were usually in agreement with those described in the literature. Growth of the variety IAC-47 (number of leaves, tillering and total dry matter) was relatively more affected; this variety, however did produce grains under the minus Cu treatment (one fourth of the yield observed in the "complete" treatment), which did not happen in the case of the other variety. At the beginning of the grain filling period the following leaf contents could be considered as indication of deficiency: B-13 to 25 ppm; Zn-20 ppm; no conclusion could be drawn with respect to Cu levels.Plantas de arroz, variedades IAC-25 e IAC-47 foram cultivadas em solução nutritiva e com deficiência de B, Cu e Zn. Foram obtidos sintomas de carência dos três micronutrientes. As deficiências induzidas provocaram diminuição na matéria seca total e no número de folhas das duas variedades. O mesmo ocorreu no numero de perfilhos da var. IAC-47. Foi feita a determinação dos teores dos micronutrientes nas plantas submetidas aos diferentes tratamentos o que forneceu dados que ajudam a avaliação do estado nutricional