INFLUENZA DEL SOTTOSUOLO SUL COMPORTAMENTO DINAMICO DEL CAMPANILE DEL CARMINE A NAPOLI

La nota descrive l’identificazione dinamica del campanile del Carmine a Napoli, effettuata attraverso analisi dinamiche su un modello tridimensionale del sistema terreno - fondazione - struttura, tarato sui risultati di dettagliate indagini in situ. Sono stati riconosciuti fenomeni di risonanza tra la frequenza fondamentale del terreno e la seconda frequenza di vibrazione della struttura che ne condizionano il comportamento dinamico

A Step Into the Definition of the Seismic Risk for the City of Benevento (Italy)

This paper gives a contribution in the definition of the seismic hazard for the city of Benevento in Southern Italy, from a geotechnical engineering viewpoint. To pursue this goal, an extensive geotechnical characterization of the city subsoil was achieved collecting data available at the Department of Geotechnical Engineering, University of Napoli and Benevento municipal technical office. Attention was paid in defining strain dependent shear stiffness and damping ratio for the geomaterials present in the urban area. A new method to correct the Masing criteria was adopted. Numerical analyses were performed considering the subsoil as a continuous one-phase equivalent linear medium. The 1-D analyses were carried out using Shake-like codes. The seismic hazard in the city was evaluated on the basis of two seismic scenarios, respectively characterized by low and high acceleration levels. The final result of the work is a seismic zonation of the city of Benevento. It was found that zonation maps are largely dependent from the chosen seismic scenario

A Step Into the Definition of the Seismic Risk for the City of Benevento (Italy)

This paper gives a contribution in the definition of the seismic hazard for the city of Benevento in Southern Italy, from a geotechnical engineering viewpoint. To pursue this goal, an extensive geotechnical characterization of the city subsoil was achieved collecting data available at the Department of Geotechnical Engineering, University of Napoli and Benevento municipal technical office. Attention was paid in defining strain dependent shear stiffness and damping ratio for the geomaterials present in the urban area. A new method to correct the Masing criteria was adopted. Numerical analyses were performed considering the subsoil as a continuous one-phase equivalent linear medium. The 1-D analyses were carried out using Shake-like codes. The seismic hazard in the city was evaluated on the basis of two seismic scenarios, respectively characterized by low and high acceleration levels. The final result of the work is a seismic zonation of the city of Benevento. It was found that zonation maps are largely dependent from the chosen seismic scenario

ISSR markers show differentiation among Italian populations of Asparagus acutifolius L

BACKGROUND: Asparagus acutifolius L. is a dioecious and native plant species, widely distributed in the Mediterranean Basin. It is known for its fine flavour and could represent an important resource for cultivation programs in desert areas. Few molecular studies have been performed on this species. In the present paper, the ISSR technique was employed to study genetic diversity in Italian A. acutifolius. RESULTS: Twenty-three primers produced a total of 228 polymorphic fragments used to evaluate genetic variation. F(ST )(0.4561) and Theta B (0.4776) values indicate a wide genetic variation among the samples examined. The distance UPGMA tree grouped together the genotypes strictly according to their geographical origin, showing that each sample is genetically structured and can be considered a distinct population. AMOVA analysis further confirmed genetic structuring of the populations. Population-specific fragments were also detected. CONCLUSION: The results suggest that ISSR markers are useful in distinguishing the populations of A. acutifolius according to geographical origin, and confirm the importance of genetic studies for designing germplasm conservation strategies

Suction-induced effects on the seismic response of a zoned earth dam through simplified dynamic analyses

In zoned earth dams, the contrast in hydraulic conductivity between the core and the shells causes the saturation line to drop across the core, leaving most of the downstream shell in an unsaturated state. Since suction provides for additional stiffness and strength to soil, the paper investigates the contribution of suction-induced effects in the downstream shell and other dam zones located above the saturation line on the seismic response of the dam. To this aim, a Newmark-based approach has been adopted. The seismic response of the dam is first analysed by equivalent linear dynamic analyses to obtain the equivalent acceleration acting throughout the sliding mass, which is then employed in the application of the Newmark method. Since critical surfaces for zoned earth dams are those crossing the core, the study focuses on sliding mechanisms involving these surfaces

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN