Half-Heard Voices of the Primal Zone; Sleep and Waking in a Poem by Cao Shuying

Initially touching artifacts and sculpture from ancient Greece, and the risk of misreading thought or emotion cross-culturally, this essay draws briefly on Wordsworth’s testimony that poetic process arises first in a primally sensual and pre-verbal zone. The essay then proposes that similar practice, carried by craft and poetic experience in the target language, may be equally advantageous in poetry translation, while helping bridge individual and cross-cultural differences. In light of this, the essay’s second half addresses translational details in rendering Cao Shuying’s poem “I Often Read, Early Mornings.

Characterization of Electronic Cigarette Aerosol and Its Induction of Oxidative Stress Response in Oral Keratinocytes.

In this study, we have generated and characterized Electronic Cigarette (EC) aerosols using a combination of advanced technologies. In the gas phase, the particle number concentration (PNC) of EC aerosols was found to be positively correlated with puff duration whereas the PNC and size distribution may vary with different flavors and nicotine strength. In the liquid phase (water or cell culture media), the size of EC nanoparticles appeared to be significantly larger than those in the gas phase, which might be due to aggregation of nanoparticles in the liquid phase. By using in vitro high-throughput cytotoxicity assays, we have demonstrated that EC aerosols significantly decrease intracellular levels of glutathione in NHOKs in a dose-dependent fashion resulting in cytotoxicity. These findings suggest that EC aerosols cause cytotoxicity to oral epithelial cells in vitro, and the underlying molecular mechanisms may be or at least partially due to oxidative stress induced by toxic substances (e.g., nanoparticles and chemicals) present in EC aerosols

Assessment of Precise Land Levelling on Surface Irrigation Development. Impacts on MaizeWater Productivity and Economics

The new technologies of surface irrigation require the adoption of effective Laser-controlled precision land levelling (PLL) to reach the high irrigation performance standards, with significant benefits on water saving, salinity control, crop productivity, and farmer’s income. This study aimed to assess the performance and the impacts of PLL on surface irrigation systems, focusing the maize crop on the irrigation districts Hetao (China) and Lower-Mondego (Portugal). The experimental study at field scale assessed the PLL and evaluated the on-farm irrigation under precise levelled fields and well management practices. PLL operators have been inquired to improve the knowledge about hiring services. The design of surface irrigation scenarios allowed to explain the effects of field size and slope on irrigation and land levelling performance. The best practice to manage the PLL maintenance is an important issue to guarantee a high effectiveness of irrigation performance. The optimization of PLL appeals the application of best soil tillage practices and the monitoring of soil surface elevations with newest information technologies. Efficient operational guidelines to support the PLL planning, schedule, and operation, well trained operators and carefully adjusted equipment, are key factors to the improvementinfo:eu-repo/semantics/publishedVersio

Alzheimer's disease diagnosis and management: Perspectives from around the world

Alzheimer's disease (AD) and other dementias are a global challenge. Early diagnosis is important to manage the disease. However, there are barriers to diagnosis that differ by region. Researchers from Brazil, China, Nigeria, Spain, and Sweden have identified key barriers to AD diagnosis in their countries. In Brazil, socioeconomic inequalities and poor recognition of dementia by physicians can prevent diagnosis. In China, a very large population and lack of physician training in dementia make diagnosis problematic. In Nigeria, socioeconomic inequalities and cultural stigma can stand in the way of diagnosis. In Spain, patient hesitancy and an overloaded health-care system are barriers to diagnosis. In Sweden, inconsistent use of biomarkers is a prominent barrier to diagnosis of AD. To support diagnosis, more focus is needed on education of patients and physicians, increased use of support services, and improved access to biomarkers to accurately diagnose AD

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

SummaryDefective apoptosis renders immortalized epithelial cells highly tumorigenic, but how this is impacted by other common tumor mutations is not known. In apoptosis-defective cells, inhibition of autophagy by AKT activation or by allelic disruption of beclin1 confers sensitivity to metabolic stress by inhibiting an autophagy-dependent survival pathway. While autophagy acts to buffer metabolic stress, the combined impairment of apoptosis and autophagy promotes necrotic cell death in vitro and in vivo. Thus, inhibiting autophagy under conditions of nutrient limitation can restore cell death to apoptosis-refractory tumors, but this necrosis is associated with inflammation and accelerated tumor growth. Thus, autophagy may function in tumor suppression by mitigating metabolic stress and, in concert with apoptosis, by preventing death by necrosis

Similar self-organizing scale-invariant properties characterize early cancer invasion and long range species spread

Occupancy of new habitats through dispersion is a central process in nature. In particular, long range dispersal is involved in the spread of species and epidemics, although it has not been previously related with cancer invasion, a process that involves spread to new tissues. We show that the early spread of cancer cells is similar to the species individuals spread and that both processes are represented by a common spatio-temporal signature, characterized by a particular fractal geometry of the boundaries of patches generated, and a power law-scaled, disrupted patch size distribution. We show that both properties are a direct result of long-distance dispersal, and that they reflect homologous ecological processes of population self-organization. Our results are significant for processes involving long-range dispersal like biological invasions, epidemics and cancer metastasis.Comment: 21 pages, 2 figure