AMI-CL J0300+2613: A Galactic anomalous-microwave-emission ring masquerading as a galaxy cluster

The Arcminute Microkelvin Imager (AMI) carried out a blind survey for galaxy clusters via their Sunyaev-Zel'dovich effect decrements between 2008 and 2011. The first detection, known as AMI-CL J0300+2613, has been reobserved with AMI equipped with a new digital correlator with high dynamic range. The combination of the new AMI data and more recent high-resolution sub-mm and infra-red maps now shows the feature in fact to be a ring of positive dust-correlated Galactic emission, which is likely to be anomalous microwave emission (AME). If so, this is the first completely blind detection of AME at arcminute scales

The Incremental Cooperative Design of Preventive Healthcare Networks

This document is the Accepted Manuscript version of the following article: Soheil Davari, 'The incremental cooperative design of preventive healthcare networks', Annals of Operations Research, first published online 27 June 2017. Under embargo. Embargo end date: 27 June 2018. The final publication is available at Springer via http://dx.doi.org/10.1007/s10479-017-2569-1.In the Preventive Healthcare Network Design Problem (PHNDP), one seeks to locate facilities in a way that the uptake of services is maximised given certain constraints such as congestion considerations. We introduce the incremental and cooperative version of the problem, IC-PHNDP for short, in which facilities are added incrementally to the network (one at a time), contributing to the service levels. We first develop a general non-linear model of this problem and then present a method to make it linear. As the problem is of a combinatorial nature, an efficient Variable Neighbourhood Search (VNS) algorithm is proposed to solve it. In order to gain insight into the problem, the computational studies were performed with randomly generated instances of different settings. Results clearly show that VNS performs well in solving IC-PHNDP with errors not more than 1.54%.Peer reviewe

Dynamic temporary blood facility location-allocation during and post-disaster periods

The key objective of this study is to develop a tool (hybridization or integration of different techniques) for locating the temporary blood banks during and post-disaster conditions that could serve the hospitals with minimum response time. We have used temporary blood centers, which must be located in such a way that it is able to serve the demand of hospitals in nearby region within a shorter duration. We are locating the temporary blood centres for which we are minimizing the maximum distance with hospitals. We have used Tabu search heuristic method to calculate the optimal number of temporary blood centres considering cost components. In addition, we employ Bayesian belief network to prioritize the factors for locating the temporary blood facilities. Workability of our model and methodology is illustrated using a case study including blood centres and hospitals surrounding Jamshedpur city. Our results shows that at-least 6 temporary blood facilities are required to satisfy the demand of blood during and post-disaster periods in Jamshedpur. The results also show that that past disaster conditions, response time and convenience for access are the most important factors for locating the temporary blood facilities during and post-disaster periods

Adaptive mechanisms of plants against salt stress and salt shock

Salinization process occurs when soil is contaminated with salt, which consequently influences plant growth and development leading to reduction in yield of many food crops. Responding to a higher salt concentration than the normal range can result in plant developing complex physiological traits and activation of stress-related genes and metabolic pathways. Many studies have been carried out by different research groups to understand adaptive mechanism in many plant species towards salinity stress. However, different methods of sodium chloride (NaCl) applications definitely give different responses and adaptive mechanisms towards the increase in salinity. Gradual increase in NaCl application causes the plant to have salt stress or osmotic stress, while single step and high concentration of NaCl may result in salt shock or osmotic shock. Osmotic shock can cause cell plasmolysis and leakage of osmolytes in plant. Also, the gene expression pattern is influenced by the type of methods used in increasing the salinity. Therefore, this chapter discusses the adaptive mechanism in plant responding to both types of salinity increment, which include the morphological changes of plant roots and aerial parts, involvement of signalling molecules in stress perception and regulatory networks and production of osmolyte and osmoprotective proteins

The association of 1661AG polymorphism for CTLA-4 gene in patients with systemic lupus erythematosus

Background: Cytotoxic lymphocyte antigen-4 (CTLA-4) plays an important role in regulating T cell activation. CTLA-4 gene polymorphism is related to genetic susceptibility to various autoimmune diseases, including systemic lupus erythematosus (SLE). This study aimed to evaluate the role of CTLA-4 polymorphism at positions-1661AG in patients with SLE. Materials and Methods: This study was performed on 180 SLE patients referred to 5th Azar educational hospital (Gorgan, Iran, during 2010-2011) and 304 ethnically-and age-matched healthy controls. Polymerase chain reaction restriction fragments length polymorphism (PCR-RFLP) was used to analyze the genotype and allele frequencies of this polymorphism. Results: No statistically significant difference was observed between the studied genotypic and allelic frequencies between the SLE patients and healthy controls. Moreover, no significant correlation was found between the different risk factors (e.g., age, ethnicity, history of the disease and the parents' relationship) and the different genotypes. Conclusion: Results suggest that the -1661AG polymorphism in the promoter region of the CTLA-4 gene has no role in the genetic susceptibility to SLE

A digital correlator upgrade for the Arcminute MicroKelvin Imager

The Arcminute Microkelvin Imager (AMI) telescopes located at the Mullard Radio Astronomy Observatory near Cambridge have been significantly enhanced by the implementation of a new digital correlator with 1.2 MHz spectral resolution. This system has replaced a 750-MHz resolution analogue lag-based correlator, and was designed to mitigate the effects of radio frequency interference, particularly from geostationary satellites that contaminate observations at low declinations. The upgraded instrument consists of 18 ROACH2 Field Programmable Gate Array platforms used to implement a pair of real-time FX correlators -- one for each of AMI's two arrays. The new system separates the down-converted RF baseband signal from each AMI receiver into two 2.3 GHz-wide sub-bands which are each digitized at 5-Gsps with 8 bits of precision. These digital data streams are filtered into 2048 frequency channels and cross-correlated using FPGA hardware, with a commercial 10 Gb Ethernet switch providing high-speed data interconnect. Images formed using data from the new digital correlator show over an order of magnitude improvement in dynamic range over the previous system. The ability to observe at low declinations has also been significantly improved