Leadership effectiveness and its relationship with emotional stability among nurse managers in educational hospitals related to Isfahan University of Medical Science in 2007

زمینه و هدف: تغییرات گسترده ای که امروزه در مؤسسات مراقبت بهداشتی به وقوع پیوسته است ضرورت ترکیب مهارت های رهبری و مدیریت را به وجود آورده است. به علاوه، موفقیت در مراقبت از بیمار و جلب اعتبار بیمارستان تا حد زیادی به شایستگی و علاقه کارکنان پرستاری بستگی دارد. هدف این پژوهش تعیین اثربخشی رهبری و ارتباط آن با ثبات عاطفی در مدیران پرستاری می باشد. روش بررسی: این پژوهش از نوع توصیفی همبستگی بود که در سال 1386 بر روی 128 نفر از مدیران پرستاری بیمارستان های آموزشی وابسته به دانشگاه علوم پزشکی شهر اصفهان با روش نمونه گیری سرشماری انجام شد. ابزار جمع آوری اطلاعات پرسشنامه اصول رهبری اثربخش و پرسشنامه شخصیت کنتل (Kentel) بود. در این پژوهش اثربخشی رهبری و ثبات عاطفی مورد سنجش قرار گرفت. یافته ها: یافته های پژوهش نشان داد که 8/77 مدیران خدمات پرستاری، 7/66 سوپروایزران و 1/72 سرپرستاران مورد پژوهش اثربخشی رهبری قوی داشته اند. همچنین بین اثربخشی رهبری و ثبات عاطفی در رده سوپروایزران همبستگی مستقیم و معنی دار وجود داشت (02/0 = Pو 39/0r=-) اما در سایر رده ها بین اثربخشی رهبری و ثبات عاطفی همبستگی معنی داری مشاهده نشد. نتیجه گیری: نتایج نشان داد بین اثربخشی رهبری و ثبات عاطفی در رده سوپروایزران، ارتباط مستقیمی وجود دارد لذا توجه به ویژگی های شخصیتی در انتخاب این مدیران باید مورد توجه قرار گیرد

Stock assessment of freshwater crayfish (Astacus leptodactylus) in Aras reservoir

360 funnel traps were prepared as 30 in one row. They were bitted and located in different depths in sampling sites. Two rows each composed of 30 traps were located by stone, linking rope and boat with 50 m distance in sampling stations. The results showed that the average of total length of caught crayfish was 106.26±12.89 mm and their mean weight was 38.79 ± 15.54 gr. The largest crayfish had 171 mm length and 216 g weight. Also mean of total CPUE was 9.72±4.49 individuals in the study period. The evaluation by Schnabel approach indicated that fluctuation range of freshwater crayfish biomass with more than 120mm length was 131-313 with an average of 212.59 ±30.23 kilograms per ha. In this study freshwater crayfish biomass with more than 120mm length was 247 × 10^3 kilograms. The Maximum Sustainable Yield (MSY) was estimated 83 × 10^3 kilograms. In this study ّFecundity and biometry of crayfish (Astacus leptodactylus) was investigated during 2012-2013. The results showed that the average of total length of caught crayfish was 106.26±12.89 mm and their mean weight was 38.79 ± 15.54 gr. The largest crayfish had 171 mm length and 216 g weight. Mean number of ovarian and pleopodal eggs were estimated at 286 ± 82 and 246.31 ± 80.41 eggs (with 95% confidence limits), respectively. In this research, male to female ratio was obtained 1.21:1. The time of male moulting at 16°C was started from April and was ended in the late May, when the water temperature reached to 18° C. The second moulting of males and the first moulting of females was performed simultaneously in 18°C water temperature at September. Reproduction of freshwater crayfish was started from November and continued to May of the next year. Harvesting period was from May to late November

Nutraceutical agents with anti-inflammatory properties prevent dietary saturated-fat induced disturbances in blood-brain barrier function in wild-type mice

Background: Emerging evidence suggests that disturbances in the blood–brain barrier (BBB) may be pivotal to the pathogenesis and pathology of vascular-based neurodegenerative disorders. Studies suggest that heightened systemic and central inflammations are associated with BBB dysfunction. This study investigated the effect of the anti-inflammatory nutraceuticals garlic extract-aged (GEA), alpha lipoic acid (ALA), niacin, and nicotinamide (NA) in a murine dietary-induced model of BBB dysfunction. Methods: C57BL/6 mice were fed a diet enriched in saturated fatty acids (SFA, 40% fat of total energy) for nine months to induce systemic inflammation and BBB disturbances. Nutraceutical treatment groups included the provision of either GEA, ALA, niacin or NA in the positive control SFA-group and in low-fat fed controls. Brain parenchymal extravasation of plasma derived immunoglobulin G (IgG) and large macromolecules (apolipoprotein (apo) B lipoproteins) measured by quantitative immunofluorescent microscopy, were used as markers of disturbed BBB integrity. Parenchymal glial fibrillar acidic protein (GFAP) and cyclooxygenase-2 (COX-2) were considered in the context of surrogate markers of neurovascular inflammation and oxidative stress. Total anti-oxidant status and glutathione reductase activity were determined in plasma.Results: Brain parenchymal abundance of IgG and apoB lipoproteins was markedly exaggerated in mice maintained on the SFA diet concomitant with significantly increased GFAP and COX-2, and reduced systemic antioxidative status. The nutraceutical GEA, ALA, niacin, and NA completely prevented the SFA-induced disturbances of BBB and normalized the measures of neurovascular inflammation and oxidative stress. Conclusions: The anti-inflammatory nutraceutical agents GEA, ALA, niacin, or NA are potent inhibitors of dietary fat-induced disturbances of BBB induced by systemic inflammations

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Background: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to 2017. Previous GBD studies have shown how the decline of mortality rates from 1990 to 2016 has led to an increase in life expectancy, an ageing global population, and an expansion of the non-fatal burden of disease and injury. These studies have also shown how a substantial portion of the world's population experiences non-fatal health loss with considerable heterogeneity among different causes, locations, ages, and sexes. Ongoing objectives of the GBD study include increasing the level of estimation detail, improving analytical strategies, and increasing the amount of high-quality data. Methods: We estimated incidence and prevalence for 354 diseases and injuries and 3484 sequelae. We used an updated and extensive body of literature studies, survey data, surveillance data, inpatient admission records, outpatient visit records, and health insurance claims, and additionally used results from cause of death models to inform estimates using a total of 68 781 data sources. Newly available clinical data from India, Iran, Japan, Jordan, Nepal, China, Brazil, Norway, and Italy were incorporated, as well as updated claims data from the USA and new claims data from Taiwan (province of China) and Singapore. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between rates of incidence, prevalence, remission, and cause of death for each condition. YLDs were estimated as the product of a prevalence estimate and a disability weight for health states of each mutually exclusive sequela, adjusted for comorbidity. We updated the Socio-demographic Index (SDI), a summary development indicator of income per capita, years of schooling, and total fertility rate. Additionally, we calculated differences between male and female YLDs to identify divergent trends across sexes. GBD 2017 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting. Findings: Globally, for females, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and haemoglobinopathies and haemolytic anaemias in both 1990 and 2017. For males, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and tuberculosis including latent tuberculosis infection in both 1990 and 2017. In terms of YLDs, low back pain, headache disorders, and dietary iron deficiency were the leading Level 3 causes of YLD counts in 1990, whereas low back pain, headache disorders, and depressive disorders were the leading causes in 2017 for both sexes combined. All-cause age-standardised YLD rates decreased by 3·9% (95% uncertainty interval [UI] 3·1–4·6) from 1990 to 2017; however, the all-age YLD rate increased by 7·2% (6·0–8·4) while the total sum of global YLDs increased from 562 million (421–723) to 853 million (642–1100). The increases for males and females were similar, with increases in all-age YLD rates of 7·9% (6·6–9·2) for males and 6·5% (5·4–7·7) for females. We found significant differences between males and females in terms of age-standardised prevalence estimates for multiple causes. The causes with the greatest relative differences between sexes in 2017 included substance use disorders (3018 cases [95% UI 2782–3252] per 100 000 in males vs s1400 [1279–1524] per 100 000 in females), transport injuries (3322 [3082–3583] vs 2336 [2154–2535]), and self-harm and interpersonal violence (3265 [2943–3630] vs 5643 [5057–6302]). Interpretation: Global all-cause age-standardised YLD rates have improved only slightly over a period spanning nearly three decades. However, the magnitude of the non-fatal disease burden has expanded globally, with increasing numbers of people who have a wide spectrum of conditions. A subset of conditions has remained globally pervasive since 1990, whereas other conditions have displayed more dynamic trends, with different ages, sexes, and geographies across the globe experiencing varying burdens and trends of health loss. This study emphasises how global improvements in premature mortality for select conditions have led to older populations with complex and potentially expensive diseases, yet also highlights global achievements in certain domains of disease and injury

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Not AvailableFoot-and-mouth disease (FMD) is an economically important, global disease of cloven-hoofed animals. The conventional vaccine could bring down the incidence of disease in many parts of the world but has many limitations and in India, the disease is enzootic. More promisingly, the alternate vaccine candidates, virus-like particles (VLPs) are as immunogenic as a native virus but are more labile to heat than the live virus capsids. To produce stable VLPs, a single amino acid residue was mutated at 93 and 98 positions at VP2 inter-pentamer region of the P1-2A gene of FMD virus serotype O (IND/R2/75). The mutated capsid protein was expressed in insect cells and characterized for temperature and varying pH stability. Out of S93Y, S93F, S93C, S93H, and Y98F mutant, VLPs, S93Y, S93F, and Y98F showed improved stability at 37 °C for 75 days compared to wild capsid, which was evaluated by sandwich ELISA. Further, the stability analysis of purified VLPs either by differential scanning fluorescence (DSF) stability assay at different temperatures and pH conditions or by dissociation kinetics showed that the Y98F mutant VLPs were more stable than S93Y, S93F, S93C, and S93H mutant and wild-type VLPs. Immunization of guinea pigs with Y98F VLPs induced neutralizing antibodies and 60% of the animals were protected from the FMDV "O" 100 GPID50 challenge virus.Not Availabl

Not Available

Not AvailableFoot-and-mouth disease (FMD) is an economically important, global disease of cloven-hoofed animals. The conventional vaccine could bring down the incidence of disease in many parts of the world but has many limitations and in India, the disease is enzootic. More promisingly, the alternate vaccine candidates, virus-like particles (VLPs) are as immunogenic as a native virus but are more labile to heat than the live virus capsids. To produce stable VLPs, a single amino acid residue was mutated at 93 and 98 positions at VP2 inter-pentamer region of the P1-2A gene of FMD virus serotype O (IND/R2/75). The mutated capsid protein was expressed in insect cells and characterized for temperature and varying pH stability. Out of S93Y, S93F, S93C, S93H, and Y98F mutant, VLPs, S93Y, S93F, and Y98F showed improved stability at 37 °C for 75 days compared to wild capsid, which was evaluated by sandwich ELISA. Further, the stability analysis of purified VLPs either by differential scanning fluorescence (DSF) stability assay at different temperatures and pH conditions or by dissociation kinetics showed that the Y98F mutant VLPs were more stable than S93Y, S93F, S93C, and S93H mutant and wild-type VLPs. Immunization of guinea pigs with Y98F VLPs induced neutralizing antibodies and 60% of the animals were protected from the FMDV "O" 100 GPID50 challenge viruICAR-IVR

Development and Translation of PEDOT:PSS Microelectrodes for Intraoperative Monitoring

Recording neural activity during neurosurgical interventions is an invaluable tool for both improving patient outcomes and advancing our understanding of neural mechanisms and organization. However, increasing clinical electrodes' signal-to-noise and spatial specificity requires overcoming substantial physical barriers due to the compromised metal electrochemical interface properties. The electrochemical properties of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) based interfaces surpass those of current clinical electrocorticography electrodes. Here, robust fabrication process of PEDOT:PSS microelectrode arrays is demonstrated for safe and high fidelity intraoperative monitoring of human brain. PEDOT:PSS microelectrodes measure significant differential neural modulation under various clinically relevant conditions. This study reports the first evoked (stimulus-locked) cognitive activity with changes in amplitude across pial surface distances as small as 400 µm, potentially enabling basic neurophysiology studies at the scale of neural micro-circuitry