Empirical Investigations of Reference Point Based Methods When Facing a Massively Large Number of Objectives: First Results

EMO 2017: 9th International Conference on Evolutionary Multi-Criterion Optimization, 19-22 March 2017, Münster, GermanyThis is the author accepted manuscript. The final version is available from Springer Verlag via the DOI in this record.Multi-objective optimization with more than three objectives has become one of the most active topics in evolutionary multi-objective optimization (EMO). However, most existing studies limit their experiments up to 15 or 20 objectives, although they claimed to be capable of handling as many objectives as possible. To broaden the insights in the behavior of EMO methods when facing a massively large number of objectives, this paper presents some preliminary empirical investigations on several established scalable benchmark problems with 25, 50, 75 and 100 objectives. In particular, this paper focuses on the behavior of the currently pervasive reference point based EMO methods, although other methods can also be used. The experimental results demonstrate that the reference point based EMO method can be viable for problems with a massively large number of objectives, given an appropriate choice of the distance measure. In addition, sufficient population diversity should be given on each weight vector or a local niche, in order to provide enough selection pressure. To the best of our knowledge, this is the first time an EMO methodology has been considered to solve a massively large number of conflicting objectives.This work was partially supported by EPSRC (Grant No. EP/J017515/1

Diet modulates brain network stability, a biomarker for brain aging, in young adults

Epidemiological studies suggest that insulin resistance accelerates progression of age-based cognitive impairment, which neuroimaging has linked to brain glucose hypometabolism. As cellular inputs, ketones increase Gibbs free energy change for ATP by 27% compared to glucose. Here we test whether dietary changes are capable of modulating sustained functional communication between brain regions (network stability) by changing their predominant dietary fuel from glucose to ketones. We first established network stability as a biomarker for brain aging using two large-scale (n = 292, ages 20 to 85 y; n = 636, ages 18 to 88 y) 3 T functional MRI (fMRI) datasets. To determine whether diet can influence brain network stability, we additionally scanned 42 adults, age < 50 y, using ultrahigh-field (7 T) ultrafast (802 ms) fMRI optimized for single-participant-level detection sensitivity. One cohort was scanned under standard diet, overnight fasting, and ketogenic diet conditions. To isolate the impact of fuel type, an independent overnight fasted cohort was scanned before and after administration of a calorie-matched glucose and exogenous ketone ester (D-β-hydroxybutyrate) bolus. Across the life span, brain network destabilization correlated with decreased brain activity and cognitive acuity. Effects emerged at 47 y, with the most rapid degeneration occurring at 60 y. Networks were destabilized by glucose and stabilized by ketones, irrespective of whether ketosis was achieved with a ketogenic diet or exogenous ketone ester. Together, our results suggest that brain network destabilization may reflect early signs of hypometabolism, associated with dementia. Dietary interventions resulting in ketone utilization increase available energy and thus may show potential in protecting the aging brain