1,819 research outputs found
Impact of tumour histological subtype on chemotherapy outcome in advanced oesophageal cancer.
AIM: To investigate the impact of histology on outcome in advanced oesophageal cancer treated with first-line fluoropyrimidine-based chemotherapy. METHODS: Individual patient data were pooled from three randomised phase III trials of fluoropyrimidine-based chemotherapy ± platinum/anthracycline in patients with advanced, untreated gastroesophageal adenocarcinoma or squamous cell carcinoma (SCC) randomised between 1994 and 2005. The primary endpoint was overall survival of oesophageal cancer patients according to histology. Secondary endpoints were response rates and a toxicity composite endpoint. RESULTS: Of the total 1836 randomised patients, 973 patients (53%) were eligible (707 patients with gastric cancer were excluded), 841 (86%) had adenocarcinoma and 132 (14%) had SCC. There was no significant difference in survival between patients with adenocarcinoma and SCC, with median overall survivals of 9.5 mo vs 7.6 mo (HR = 0.85, 95%CI: 0.70-1.03, P = 0.09) and one-year survivals of 38.8% vs 28.2% respectively. The overall response rate to chemotherapy was 44% for adenocarcinoma vs 33% for SCC (P = 0.01). There was no difference in the frequency of the toxicity composite endpoint between the two groups. CONCLUSION: There was no significant difference in survival between adenocarcinoma and SCC in patients with advanced oesophageal cancer treated with fluoropyrimidine-based chemotherapy despite a trend for worse survival and less chemo-sensitivity in SCC. Tolerance to treatment was similar in both groups. This analysis highlights the unmet need for SCC-specific studies in advanced oesophageal cancer and will aid in the design of future trials of targeted agents
Expansions for the Bollobas-Riordan polynomial of separable ribbon graphs
We define 2-decompositions of ribbon graphs, which generalise 2-sums and
tensor products of graphs. We give formulae for the Bollobas-Riordan polynomial
of such a 2-decomposition, and derive the classical Brylawski formula for the
Tutte polynomial of a tensor product as a (very) special case. This study was
initially motivated from knot theory, and we include an application of our
formulae to mutation in knot diagrams.Comment: Version 2 has minor changes. To appear in Annals of Combinatoric
Generic User Process Interface for Event Generators
Generic Fortran common blocks are presented for use by High Energy Physics
event generators for the transfer of event configurations from parton level
generators to showering and hadronization event generators.Comment: Physics at TeV Colliders II Workshop, Les Houches, France, May 2001
14 pages, 6 figure
Regular Tart Cherry Intake Alters Abdominal Adiposity, Adipose Gene Transcription, and Inflammation in Obesity-Prone Rats Fed a High Fat Diet
Abstract Obesity, systemic inflammation, and hyperlipidemia are among the components of metabolic syndrome, a spectrum of phenotypes that can precede the development of type 2 diabetes and cardiovascular disease. Animal studies show that intake of anthocyanin-rich extracts can affect these phenotypes. Anthocyanins can alter the activity of tissue peroxisome proliferator-activated receptors (PPARs), which affect energy substrate metabolism and inflammation. However, it is unknown if physiologically relevant, anthocyanin-containing whole foods confer similar effects to concentrated, anthocyanin extracts. The effect of anthocyanin-rich tart cherries was tested in the Zucker fatty rat model of obesity and metabolic syndrome. For 90 days, rats were pair-fed a higher fat diet supplemented with either 1% (wt/wt) freeze-dried, whole tart cherry powder or with a calorie- and macronutrient-matched control diet. Tart cherry intake was associated with reduced hyperlipidemia, percentage fat mass, abdominal fat (retroperitoneal) weight, retroperitoneal interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) expression, and plasma IL-6 and TNF-α. Tart cherry diet also increased retroperitoneal fat PPAR-α and PPAR-γ mRNA (P=.12), decreased IL-6 and TNF-α mRNA, and decreased nuclear factor κB activity. In conclusion, in at-risk obese rats fed a high fat diet, physiologically relevant tart cherry consumption reduced several phenotypes of metabolic syndrome and reduced both systemic and local inflammation. Tart cherries may reduce the degree or trajectory of metabolic syndrome, thereby reducing risk for the development of type 2 diabetes and heart disease.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78120/1/jmf.2008.0270.pd
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Studies of Basic Electronic Properties of CdTe-Based Solar Cells and Their Evolution During Processing and Stress; Annual Technical Report, 1 November 2005 - 31 October 2006
We describe the results of our continuing study of deep electronic states controlling open-circuit voltage in CdTe/CdS thin-film solar cells (Task 1). The study includes: (1) analysis of factors affecting trap signatures derived from admittance spectroscopy and capacitance transients measurements, such as activation-energy capture cross-sections and trap-density estimates, and (2) comparative studies of cells received from four different sources and prepared with significant variations in cell structure and processing procedures
Blueberry Intake Alters Skeletal Muscle and Adipose Tissue Peroxisome Proliferator-Activated Receptor Activity and Reduces Insulin Resistance in Obese Rats
Metabolic syndrome can precede the development of type 2 diabetes and cardiovascular disease and includes phenotypes such as obesity, systemic inflammation, insulin resistance, and hyperlipidemia. A recent epidemiological study indicated that blueberry intake reduced cardiovascular mortality in humans, but the possible genetic mechanisms of this effect are unknown. Blueberries are a rich source of anthocyanins, and anthocyanins can alter the activity of peroxisome proliferator-activated receptors (PPARs), which affect energy substrate metabolism. The effect of blueberry intake was assessed in obesity-prone rats. Zucker Fatty and Zucker Lean rats were fed a higher-fat diet (45% of kcal) or a lower-fat diet (10% of kcal) containing 2% (wt/wt) freeze-dried whole highbush blueberry powder or added sugars to match macronutrient and calorie content. In Zucker Fatty rats fed a high-fat diet, the addition of blueberry reduced triglycerides, fasting insulin, homeostasis model index of insulin resistance, and glucose area under the curve. Blueberry intake also reduced abdominal fat mass, increased adipose and skeletal muscle PPAR activity, and affected PPAR transcripts involved in fat oxidation and glucose uptake/oxidation. In Zucker Fatty rats fed a low-fat diet, the addition of blueberry also significantly reduced liver weight, body weight, and total fat mass. Finally, Zucker Lean rats fed blueberry had higher body weight and reduced triglycerides, but all other measures were unaffected. In conclusion, whole blueberry intake reduced phenotypes of metabolic syndrome in obesity-prone rats and affected PPAR gene transcripts in adipose and muscle tissue involved in fat and glucose metabolism.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90448/1/jmf-2E2010-2E0292.pd
The repeating Fast Radio Burst FRB 121102: Multi-wavelength observations and additional bursts
We report on radio and X-ray observations of the only known repeating Fast
Radio Burst (FRB) source, FRB 121102. We have detected six additional radio
bursts from this source: five with the Green Bank Telescope at 2 GHz, and one
at 1.4 GHz at the Arecibo Observatory for a total of 17 bursts from this
source. All have dispersion measures consistent with a single value (
pc cm) that is three times the predicted maximum Galactic value. The
2-GHz bursts have highly variable spectra like those at 1.4 GHz, indicating
that the frequency structure seen across the individual 1.4 and 2-GHz
bandpasses is part of a wideband process. X-ray observations of the FRB 121102
field with the Swift and Chandra observatories show at least one possible
counterpart; however, the probability of chance superposition is high. A radio
imaging observation of the field with the Jansky Very Large Array at 1.6 GHz
yields a 5 upper limit of 0.3 mJy on any point-source continuum
emission. This upper limit, combined with archival WISE 22-m and IPHAS
H surveys, rules out the presence of an intervening Galactic HII
region. We update our estimate of the FRB detection rate in the PALFA survey to
be 1.1 FRBs sky day (95% confidence)
for peak flux density at 1.4 GHz above 300 mJy. We find that the intrinsic
widths of the 12 FRB 121102 bursts from Arecibo are, on average, significantly
longer than the intrinsic widths of the 13 single-component FRBs detected with
the Parkes telescope.Comment: 18 pages, 5 figures. Accepted for publication in Ap
The Astrophysics of Star Formation Across Cosmic Time at >10 GHz with the Square Kilometre Array
Testing Consumer Rationality using Perfect Graphs and Oriented Discs
Given a consumer data-set, the axioms of revealed preference proffer a binary
test for rational behaviour. A natural (non-binary) measure of the degree of
rationality exhibited by the consumer is the minimum number of data points
whose removal induces a rationalisable data-set.We study the computational
complexity of the resultant consumer rationality problem in this paper. This
problem is, in the worst case, equivalent (in terms of approximation) to the
directed feedback vertex set problem. Our main result is to obtain an exact
threshold on the number of commodities that separates easy cases and hard
cases. Specifically, for two-commodity markets the consumer rationality problem
is polynomial time solvable; we prove this via a reduction to the vertex cover
problem on perfect graphs. For three-commodity markets, however, the problem is
NP-complete; we prove thisusing a reduction from planar 3-SAT that is based
upon oriented-disc drawings
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