10 research outputs found
On Nichols algebras over SL(2,Fq) and GL(2,Fq)
We compute necessary conditions on Yetter-Drinfeld modules over the groups
SL(2,Fq) and GL(2,Fq) to generate finite dimensional Nichols algebras. This is
a first step towards a classification of pointed Hopf algebras with a group of
group-likes isomorphic to one of these groups.Comment: Major exposition revision, including referees remarks. To appear in
J. Math. Phys. 13 page
On Nichols algebras over PGL(2,q) and PSL(2,q)
We compute necessary conditions on Yetter-Drinfeld modules over the groups
\mathbf{PGL}(2,q)=\mathbf{PGL}(2,\FF_q) and
\mathbf{PSL}(2,q)=\mathbf{PSL}(2,\FF_q) to generate finite dimensional
Nichols algebras. This is a first step towards a classification of pointed Hopf
algebras with group of group-likes isomorphic to one of these groups.
As a by-product of the techniques developed in this work, we prove that there
is no non-trivial finite-dimensional pointed Hopf algebra over the Mathieu
groups and .Comment: Minor change
Cancer and mitochondrial function
Se ha descrito que algunas alteraciones del metabolismo están asociadas con la pérdida de función mitocondrial en células tumorales. Aún se discute si tal pérdida se evidencia en la función o si la célula brinda máxima estabilidad a sus funciones, se requieren más estudios para conocer el comportamiento del cáncer en la mitocondria. Cuando tiene limitación de oxígeno y mutaciones en oncogenes, genes supresores de tumor y enzimas de la vía glucolítica o del metabolismo oxidativo mitocondrial, la célula tumoral permite la formación de un cáncer agresivo. Este artículo es producto de la revisión bibliográfica de la evidencia científica que se ha presentado en las últimas investigaciones respecto al cáncer y la función mitocondrial.Metabolism alterations are associated with the loss of mitochondrial function in tumor cells. Current research discuss whether such loss is evident in function itself, or if cells can provide maximum stability to its functions. More studies are needed to determine the behavior of cancer in mitochondria. Tumor cells experience a limitation of oxygen and mutations in oncogenes, tumor suppressor genes and enzymes of the glycolytic pathway and/or mitochondrial oxidative metabolism, thus allowing the formation of aggressive cancer. This article is the result of a literature review of the scientific evidence that has been presented in the latest research on cancer and mitochondrial function
El rol de VEGF en la Angiogénesis fisiológica y tumoral
El proceso de angiogénesis, en el cual se desarrollan nuevos vasos sanguíneos a partir de una red vascular existente, requiere de la activación de los receptores en la superficie de las células endoteliales. En sus procesos fisiológicos, como la reparación de heridas, se observa un aumento en la permeabilidad vascular que induce el depósito de proteínas plasmáticas en la matriz extracelular y favorece la reparación y la cicatrización. No obstante, en algunas patologías como el cáncer, desempeña un papel importante para el crecimiento y la diseminación de las células tumorales. Su activación en el tumor permite, pero no garantiza, la expansión tumoral y, por ende, la ausencia de angiogénesis puede limitar el crecimiento. Por eso, se han desarrollado varios inhibidores con el propósito de interferir específicamente en diferentes etapas de este proceso, por ejemplo, el bevacizumab (Avastin) que se distingue como un anticuerpo monoclonal que reconoce y se une al Factor de Crecimiento Endotelial Vascular (por sus siglas en inglés VEGF).
The role of VEGF in Physiological and tumoral angiogénesis
Abstract
Angiogenesis, the cellular process leading to the development of new blood vessels from an existing vascular network, requires activation of surface receptors of normal endothelial cells by signaling molecules such as the Vascular Endothelial Growth Factor (VEGF). During physiological processes of angiogenesis leading to injury repair, an increase of vascular permeability favors deposits of plasma proteins in the extracellular matrix. However, in pathological processes such as cancer, angiogenesis plays an important role in the growth and proliferation of the tumor cells. The activation of angiogenesis in a tumor induces, but does not guarantee, tumor expansion; hence, the absence of angiogenesis may limit the tumor growth. Angiogenesis inhibitors been developed to interfere with different stages of the process. For example, bevacizumab (Avastin) is recognized as a monoclonal antibody binds specifically to VEGF and inhibits its angiogenic function
Cancer and mitochondrial function
Metabolism alterations are associated with the loss of mitochondrial function in tumor cells. Current research discuss whether such loss is evident in function itself, or if cells can provide maximum stability to its functions. More studies are needed to determine the behavior of cancer in mitochondria. Tumor cells experience a limitation of oxygen and mutations in oncogenes, tumor suppressor genes and enzymes of the glycolytic pathway and/or mitochondrial oxidative metabolism, thus allowing the formation of aggressive cancer. This article is the result of a literature review of the scientific evidence that has been presented in the latest research on cancer and mitochondrial function.Se ha descrito que algunas alteraciones del metabolismo están asociadas con la pérdida de función mitocondrial en células tumorales. Aún se discute si tal pérdida se evidencia en la función o si la célula brinda máxima estabilidad a sus funciones, se requieren más estudios para conocer el comportamiento del cáncer en la mitocondria. Cuando tiene limitación de oxígeno y mutaciones en oncogenes, genes supresores de tumor y enzimas de la vía glucolítica o del metabolismo oxidativo mitocondrial, la célula tumoral permite la formación de un cáncer agresivo. Este artículo es producto de la revisión bibliográfica de la evidencia científica que se ha presentado en las últimas investigaciones respecto al cáncer y la función mitocondrial
El cáncer en la función mitocondrial
Metabolism alterations are associated with the loss of mitochondrial function in tumor cells. Current research discuss whether such loss is evident in function itself, or if cells can provide maximum stability to its functions. More studies are needed to determine the behavior of cancer in mitochondria. Tumor cells experience a limitation of oxygen and mutations in oncogenes, tumor suppressor genes and enzymes of the glycolytic pathway and/or mitochondrial oxidative metabolism, thus allowing the formation of aggressive cancer. This article is the result of a literature review of the scientific evidence that has been presented in the latest research on cancer and mitochondrial function
Santos e devotos no império ultramarino português
O artigo faz uma história da coleção de vilancicos de São Gonçalo de Amarante, que integram a Coleção Barbosa Machado na Biblioteca Nacional do Rio de Janeiro e, simultaneamente, apresenta reflexões sobre a relação santo-devoto no Império Ultramarino Português no século XVIII. Os vilancicos são identificados como um gênero retórico poético que evoca o santo e uma prática religiosa que contrastava com outras. Parte-se de uma perspectiva comparativa entre os vilancicos e outras evidências sobre a relação santo-devoto e, em particular, sobre o santo e sua festa na sociedade colonial escravista. O artigo dialoga com a historiografia centrada na noção de Império e com uma bibliografia da História e das Ciências Sociais voltada para a relação santodevoto, a santidade e as festas.<br>The paper produces a story of vilancicos for Saint Gonçalo do Amarante, that are part of the Rio de Janeiro National Library Barbosa Machado Collection and presents reflections on the relation saint-devotees in the Portuguese Overseas Empire during the 18th century. The vilancicos are identified as a rhetoric poetic genre that reminds the saint and a religious practice that contrasted with others. It starts from a comparative perspective between the vilancicos and other evidences about the relation saint-devotee, and in particular, about the saint and his feast in a colonial and proslavery society. The article deals with the historiography centered in the notion of Empire, and with a bibliography of History and Social Sciences pointed to the relation saint-devotee, the holiness and the feasts