Maintenance of Railway Infrastructure Using Cyber-Physical Systems

Cyber-physical systems (CPS) facilitate the recent advancements in manufacturing to make it a comprehensive system that incorporates computational intelligence, communication technologies, context-awareness and data analytics. The potential of CPS is not only confined to manufacturing but are also applicable to other complex infrastructure systems that necessitate improved life cycle and asset management system. The maintenance of such a system of systems necessitates a holistic view of the infrastructure for effective decision support methodologies. This paper discusses infrastructure maintenance from the viewpoint of life cycle management within the structure of cyber-physical systems. This paper also discusses several assisting technologies to support the development of CP. In addition, some use cases are provided from the literature and based on their experience, a CPS framework is developed for Swedish Railway Infrastructure. This CPS system also enables the development of Digital Twin for Railways.ISBN för värdpublikation: 978-981-15-3642-7, 978-981-15-3643-4</p

小児重症デング熱発症前早期バイオマーカー候補分子のプロテオーム解析による同定

Background: Severe dengue with severe plasma leakage (SD-SPL) is the most frequent of dengue severe form. Plasma biomarkers for early predictive diagnosis of SD-SPL are required in the primary clinics for the prevention of dengue death. Methodology: Among 63 confirmed dengue pediatric patients recruited, hospital based longitudinal study detected six SD-SPL and ten dengue with warning sign (DWS). To identify the specific proteins increased or decreased in the SD-SPL plasma obtained 6?48 hours before the shock compared with the DWS, the isobaric tags for relative and absolute quantification (iTRAQ) technology was performed using four patients each group. Validation was undertaken in 6 SD-SPL and 10 DWS patients. Principal findings: Nineteen plasma proteins exhibited significantly different relative concentrations (p<0.05), with five over-expressed and fourteen under-expressed in SD-SPL compared with DWS. The individual protein was classified to either blood coagulation, vascular regulation, cellular transport-related processes or immune response. The immunoblot quantification showed angiotensinogen and antithrombin III significantly increased in SD-SPL whole plasma of early stage compared with DWS subjects. Even using this small number of samples, antithrombin III predicted SD-SPL before shock occurrence with accuracy. Conclusion: Proteins identified here may serve as candidate predictive markers to diagnose SD-SPL for timely clinical management. Since the number of subjects are small, so further studies are needed to confirm all these biomarkers.長崎大学学位論文 学位記番号:博(医歯薬)甲第862号 学位授与年月日:平成28年3月18日Author: Dang My Nhi, Nguyen Tien Huy, Kaname Ohyama, Daisuke Kimura, Nguyen Thi Phuong Lan, Leo Uchida, Nguyen Van Thuong, Cao Thi My Nhon, Le Hong Phuc, Nguyen Thi Mai, Shusaku Mizukami, Lam Quoc Bao, Nguyen Ngoc Doan, Nguyen Van Thanh Binh, Luong Chan Quang, Juntra Karbwang, Katsuyuki Yui, Kouichi Morita, Vu Thi Que Huong, Kenji HirayamaCitation: PLoS Neglected Tropical Diseases, 10(2), e0004435; 2016Nagasaki University (長崎大学)課程博