The Virginia Sickle Cell Anemia Awareness Program: Education, Screening, and Counseling

In 1968, a program of screening for sickle trait carriers was begun as part of the work of the Hematology Division, Department of Medicine, at the Medical College of Virginia. It was felt that sickle cell anemia was more of a public health problem than was generally recognized, and in addition to instituting screening and education programs, data were collected to document the relative neglect of the problem

Size effects and dislocation patterning in two-dimensional bending

We perform atomistic Monte Carlo simulations of bending a Lennard-Jones single crystal in two dimensions. Dislocations nucleate only at the free surface as there are no sources in the interior of the sample. When dislocations reach sufficient density, they spontaneously coalesce to nucleate grain boundaries, and the resulting microstructure depends strongly on the initial crystal orientation of the sample. In initial yield, we find a reverse size effect, in which larger samples show a higher scaled bending moment than smaller samples for a given strain and strain rate. This effect is associated with source-limited plasticity and high strain rate relative to dislocation mobility, and the size effect in initial yield disappears when we scale the data to account for strain rate effects. Once dislocations coalesce to form grain boundaries, the size effect reverses and we find that smaller crystals support a higher scaled bending moment than larger crystals. This finding is in qualitative agreement with experimental results. Finally, we observe an instability at the compressed crystal surface that suggests a novel mechanism for the formation of a hillock structure. The hillock is formed when a high angle grain boundary, after absorbing additional dislocations, becomes unstable and folds to form a new crystal grain that protrudes from the free surface.Comment: 15 pages, 8 figure

Configurations of Extremal Even Unimodular Lattices

We extend the results of Ozeki on the configurations of extremal even unimodular lattices. Specifically, we show that if L is such a lattice of rank 56, 72, or 96, then L is generated by its minimal-norm vectors.Comment: 8 pages. To appear, International Journal of Number Theor

The Lanczos algorithm with selective orthogonalization

A new stable and efficient implementation of the Lanczos algorithm is presented. The algorithm is a powerful method for finding a few eigenvalues and eigenvectors at one or both ends of the spectrum of a symmetric matrix A. The algorithm is particularly effective if A is large and sparse in that the only way in which A enters the calculation is through a subroutine which computes Av for any vector v. Thus the user is free to take advantage of any sparsity structure in A and A need not even be represented as a matrix et al

Ultraviolet/X-ray variability and the extended X-ray emission of the radio-loud broad absorption line quasar PG 1004+130

We present the results of recent Chandra, XMM-Newton, and Hubble Space Telescope observations of the radio-loud (RL), broad absorption line (BAL) quasar PG 1004+130. We compare our new observations to archival X-ray and UV data, creating the most comprehensive, high signal-to-noise, multi-epoch, spectral monitoring campaign of a RL BAL quasar to date. We probe for variability of the X-ray absorption, the UV BAL, and the X-ray jet, on month-year timescales. The X-ray absorber has a low column density of $N_{H}=8\times10^{20}-4\times10^{21}$ cm$^{-2}$ when it is assumed to be fully covering the X-ray emitting region, and its properties do not vary significantly between the 4 observations. This suggests the observed absorption is not related to the typical "shielding gas" commonly invoked in BAL quasar models, but is likely due to material further from the central black hole. In contrast, the CIV BAL shows strong variability. The equivalent width (EW) in 2014 is EW=11.24$\pm$0.56 \AA, showing a fractional increase of $\Delta EW / \langle EW \rangle$=1.16$\pm$0.11 from the 2003 observation, 3183 days earlier in the rest-frame. This places PG 1004+130 among the most highly variable BAL quasars. By combining Chandra observations we create an exposure 2.5 times deeper than studied previously, with which to investigate the nature of the X-ray jet and extended diffuse X-ray emission. An X-ray knot, likely with a synchrotron origin, is detected in the radio jet ~8 arcsec (30 kpc) from the central X-ray source with a spatial extent of ~4 arcsec (15 kpc). No similar X-ray counterpart to the counterjet is detected. Asymmetric, non-thermal diffuse X-ray emission, likely due to inverse Compton scattering of Cosmic Microwave Background photons, is also detected.Comment: 15 pages, 7 figures, 3 tables. Accepted for publication in Ap

Dynamical Origin of Extrasolar Planet Eccentricity Distribution

We explore the possibility that the observed eccentricity distribution of extrasolar planets arose through planet-planet interactions, after the initial stage of planet formation was complete. Our results are based on ~3250 numerical integrations of ensembles of randomly constructed planetary systems, each lasting 100 Myr. We find that for a remarkably wide range of initial conditions the eccentricity distributions of dynamically active planetary systems relax towards a common final equilibrium distribution, well described by the fitting formula dn ~ e exp[-1/2 (e/0.3)^2] de. This distribution agrees well with the observed eccentricity distribution for e > 0.2, but predicts too few planets at lower eccentricities, even when we exclude planets subject to tidal circularization. These findings suggest that a period of large-scale dynamical instability has occurred in a significant fraction of newly formed planetary systems, lasting 1--2 orders of magnitude longer than the ~1 Myr interval in which gas-giant planets are assembled. This mechanism predicts no (or weak) correlations between semimajor axis, eccentricity, inclination, and mass in dynamically relaxed planetary systems. An additional observational consequence of dynamical relaxation is a significant population of planets (>10%) that are highly inclined (>25deg) with respect to the initial symmetry plane of the protoplanetary disk; this population may be detectable in transiting planets through the Rossiter-McLaughlin effect.Comment: Accepted to ApJ, conclusions updated to reflect the current observational constraint

Correlation length scalings in fusion edge plasma turbulence computations

The effect of changes in plasma parameters, that are characteristic near or at an L-H transition in fusion edge plasmas, on fluctuation correlation lengths are analysed by means of drift-Alfven turbulence computations. Scalings by density gradient length, collisionality, plasma beta, and by an imposed shear flow are considered. It is found that strongly sheared flows lead to the appearence of long-range correlations in electrostatic potential fluctuations parallel and perpendicular to the magnetic field.Comment: Submitted to "Plasma Physics and Controlled Fusion

The influence of defects of the fatigue resistance of butt and girth welds in A106B steel

This three-phase study was directed at developing a fitness for service defect acceptance criteria for welds with defect indications. The study focussed on A106 Gr. B steel pipe. The first phase involved a literature search and critical review to develop the preliminary acceptance criteria to the extent permitted by the data. The second phase developed data for flat plate, wall segment, and vessel specimens containing artificial or natural planar or volumetric defects. The final phase developed acceptance criteria from the test data

A microrod-resonator Brillouin laser with 240 Hz absolute linewidth

We demonstrate an ultralow-noise microrod-resonator based laser that oscillates on the gain supplied by the stimulated Brillouin scattering optical nonlinearity. Microresonator Brillouin lasers are known to offer an outstanding frequency noise floor, which is limited by fundamental thermal fluctuations. Here, we show experimental evidence that thermal effects also dominate the close-to-carrier frequency fluctuations. The 6-mm diameter microrod resonator used in our experiments has a large optical mode area of ~100 {\mu}m$^2$, and hence its 10 ms thermal time constant filters the close-to-carrier optical frequency noise. The result is an absolute laser linewidth of 240 Hz with a corresponding white-frequency noise floor of 0.1 Hz$^2$/Hz. We explain the steady-state performance of this laser by measurements of its operation state and of its mode detuning and lineshape. Our results highlight a mechanism for noise that is common to many microresonator devices due to the inherent coupling between intracavity power and mode frequency. We demonstrate the ability to reduce this noise through a feedback loop that stabilizes the intracavity power.Comment: 11 pages, 5 figure