Sex differences in time to task failure and blood flow for an intermittent isometric fatiguing contraction

The purpose of this study was to compare the time to task failure, postcontraction hyperemia, and vascular conductance of young men and women for a submaximal intermittent fatiguing contraction performed with the handgrip muscles. Twenty men and 20 women (mean SD: 22 4 years) performed an isometric contraction at 50% of maximal voluntary contraction (MVC) (6-s contraction, 4-s rest) until task failure. Forearm venous occlusion plethysmography was used to estimate the peak blood flow (after 10-min occlusion) and blood flow at rest after 6-s submaximal contractions of varying intensities, and during an intermittent fatiguing contraction at 1-min intervals and task failure. The time to task failure was longer for the women compared with the men (408 205 s vs. 297 57 s, P 0.05). Postcontraction hyperemia and vascular conductance were greater for men than for women after nonfatiguing 6-s submaximal contractions performed at 20%, 40%, 50%, 60%, and 80% of MVC force (P 0.05). In contrast, hyperemia and vascular conductance were similar for both genders when measured at 50 s into the fatiguing contraction, at each minute thereafter, and at task failure. Regression analysis indicated that the rate of electromyographic activity and perceived exertion were the significant predictors of the time to task failure. The longer time to task failure for women compared with men for an intermittent fatiguing contraction with handgrip muscles was not explained by postcontraction hyperemia or vascular conductance with fatigue

Charge Transfer Of Hydrogen Ions And Atoms In Metal Vapors

Cross sections and equilibrium fractions for energetic H+, H−, and H0 in collisions with metal vapor targets have been compiled and evaluated. Both experimental and theoretical results are reported. Sources of errors are discussed, and recommended values for the data are presented. © 1985, American Institute of Physics for the National Institute of Standards and Technology. All rights reserved

Synthesis and biological evaluation of immunoconjugates of adriamycin and a human IgM linked by poly[N5-(2-hydroxyethyl)-l-glutamine

The synthesis and purification of radiolabelled immunoconjugates, composed of a human IgM monoclonal antibody (IgM 16.88) directed against an intracellular tumour-associated antigen, the drug carrier poly[N5-(2-hydroxyethyl)--glutamine] (PHEG) and the cytostatic drug adriamycin (ADR) are described. The immunoconjugates were constructed to allow selective release of ADR in the putatively acidic environment of the tumour through a novel acid-labile maleamic acid linker. The conjugate of PHEG and the acid-labile ADR derivative effectively released ADR in cytotoxic amounts at a pH of 6.0 as judged from incubation in buffer and from inhibition of the growth of HT-29 colon tumour cells in vitro. Immunoconjugates were prepared by coupling of PHEG-ADR having a hydrolytically stable amide bond with 131I-labelled antibody through thioether bond formation involving a single thiol group at the C-terminus of the polymer chain and maleimido groups introduced onto th

D- Production By Charge Transfer Of (0.3 - 3)-keV D+ In Thick Alkaline-earth Vapor Targets: Interaction Energies For CaH+, CaH, And CaH-

Equilibrium charge-state fractions of energetic deuterium ions and atoms emerging from alkaline-earth (magnesium, calcium, strontium, and barium) vapor targets are reported in the range of 0.3- to 3-keV incident D+ energy. Deuterium negative-ion production in thick barium and calcium vapor targets equals similar production in cesium vapor (34%). Moreover, the maximum D- production in strontium vapor exceeds that for all other known gas or vapor targets and reaches 50% at 500 eV. Theory does not quantitatively describe these results, although ab initio molecular-interaction-energy calculations on the neutral and negative-ion CaH systems lead to the prediction of large D- yields at low energies. The theoretical prediction is based on the lack of a strong coupling between the negative ion and neutral molecular states. This implies that there are small D- electron-detachment cross sections at energies less than 1 keV. The present measurements agree with previous measurements done at higher energies. © 1982 The American Physical Society

How) do work placements work: scrutinising the quantitative evidence for a theory-driven future research agenda

While supervised work placements are increasingly popular in higher education, evidence regarding their effects on career outcomes remain somewhat sparse and atheoretical. The aim of this systematic literature review is to evaluate the effectiveness of placements for career outcomes and to identify any underpinning core psychological processes and to offer a theoretically grounded framework for future research. Drawing on transition theory (Schlossberg, 1981) and career construction theory (Savickas, 1997), we argue that supervised work experiences are central transition experiences that enable social learning processes and trigger changes in a person’s identity development as a professional, thereby increasing career resources and employability which in turn affect future career outcomes positively. We screened 2,394 systematically selected abstracts across several databases and disciplines. Only quantitative studies that either offered a control-group or a longitudinal design were included, resulting in an in-depth review of 40 studies, applying a rigorous evaluation protocol. Placement participation elicits an overall positive (but small) effect on career outcomes: Graduates who completed a work placement found employment more quickly. Work placements also changed students’ perceptions of self-efficacy, their knowledge, skills, and attitudes. We suggest that these changes could be seen as indicative of the proposed social learning processes and identity changes that positively affect career resources. Our review points to several gaps in the literature, and building on existing career theories, we develop a theoretical model and offer new avenues for future research to integrate the heterogenic field of placement research and inform career research in other areas

Simultaneous Petri Net Synthesis

Petri net synthesis deals with the problem whether, given a labelled transition system TS, one can find a Petri net N with an initial marking M0 such that the reachability graph of (N. M0) is isomorphic to TS. This may be preceded by a pre-synthesis phase that will quickly reject ill-formed transition systems (and give structural reasons for the failure) and otherwise build data structures needed by the proper synthesis. The last phase proceeds by solving systems of linear inequalities, and may still fail but for less transparent reasons. In this paper, we consider an extended problem. A finite set of transition systems {TS1, ...,TSm} shall be called simultaneously Petri net solvable if there is a single Petri net N with several initial markings {M01,...,M0m}, such that for every i = 1,...,m, the reachability graph of (N, M0i) is isomorphic to TSi. The focus will be on choice-free nets, that is, nets without structural choices, and we explore how previously published efficient algorithms for the pre-synthesis and proper synthesis of bounded and choice-free Petri nets can be generalised for the simultaneous pre-synthesis and synthesis of such multi-marked nets. At the same time, the choice-free pre-synthesis of a single transition system shall be strengthened by introducing new structural checks

K-shell photoionization of ground-state Li-like boron ions [B2+^{2+}]: Experiment and Theory

Absolute cross sections for the K-shell photoionization of ground-state Li-like boron [B$^{2+}$(1s$^2$2s $^2$S)] ions were measured by employing the ion-photon merged-beams technique at the Advanced Light Source synchrotron radiation facility. The energy ranges 197.5--200.5 eV, 201.9--202.1 eV of the [1s(2s\,2p)$^3$P]$^2$P${\rm ^o}$ and [1s(2s\,2p)$^1$P] $^2$P${\rm ^o}$ resonances, respectively, were investigated using resolving powers of up to 17\,600. The energy range of the experiments was extended to about 238.2 eV yielding energies of the most prominent [1s(2$\ell$\,n$\ell^{\prime}$)]$^2$P$^o$ resonances with an absolute accuracy of the order of 130 ppm. The natural linewidths of the [1s(2s\,2p)$^3$P] $^2$P${\rm ^o}$ and [1s(2s\,2p)$^1$P] $^2$P${\rm ^o}$ resonances were measured to be $4.8 \pm 0.6$ meV and $29.7 \pm 2.5$ meV, respectively, which compare favourably with theoretical results of 4.40 meV and 30.53 meV determined using an intermediate coupling R-matrix method.Comment: 6 figures and 2 table

K-shell photoionization of ground-state Li-like carbon ions [C3+^{3+}]: experiment, theory and comparison with time-reversed photorecombination

Absolute cross sections for the K-shell photoionization of ground-state Li-like carbon [C$^{3+}$(1s$^2$2s $^2$S)] ions were measured by employing the ion-photon merged-beams technique at the Advanced Light Source. The energy ranges 299.8--300.15 eV, 303.29--303.58 eV and 335.61--337.57 eV of the [1s(2s2p)$^3$P]$^2$P, [1s(2s2p)$^1$P]$^2$P and [(1s2s)$^3$S 3p]$^2$P resonances, respectively, were investigated using resolving powers of up to 6000. The autoionization linewidth of the [1s(2s2p)$^1$P]$^2$P resonance was measured to be $27 \pm 5$ meV and compares favourably with a theoretical result of 26 meV obtained from the intermediate coupling R-Matrix method. The present photoionization cross section results are compared with the outcome from photorecombination measurements by employing the principle of detailed balance.Comment: 3 figures and 2 table

Interference effects in the photorecombination of argonlike Sc3+ ions: Storage-ring experiment and theory

Absolute total electron-ion recombination rate coefficients of argonlike Sc3+(3s2 3p6) ions have been measured for relative energies between electrons and ions ranging from 0 to 45 eV. This energy range comprises all dielectronic recombination resonances attached to 3p -> 3d and 3p -> 4s excitations. A broad resonance with an experimental width of 0.89 +- 0.07 eV due to the 3p5 3d2 2F intermediate state is found at 12.31 +- 0.03 eV with a small experimental evidence for an asymmetric line shape. From R-Matrix and perturbative calculations we infer that the asymmetric line shape may not only be due to quantum mechanical interference between direct and resonant recombination channels as predicted by Gorczyca et al. [Phys. Rev. A 56, 4742 (1997)], but may partly also be due to the interaction with an adjacent overlapping DR resonance of the same symmetry. The overall agreement between theory and experiment is poor. Differences between our experimental and our theoretical resonance positions are as large as 1.4 eV. This illustrates the difficulty to accurately describe the structure of an atomic system with an open 3d-shell with state-of-the-art theoretical methods. Furthermore, we find that a relativistic theoretical treatment of the system under study is mandatory since the existence of experimentally observed strong 3p5 3d2 2D and 3p5 3d 4s 2D resonances can only be explained when calculations beyond LS-coupling are carried out.Comment: 11 pages, 7 figures, 3 tables, Phys. Rev. A (in print), see also: http://www.strz.uni-giessen.de/~k