1,134 research outputs found
Some contributions of philosophy to education
Of what use is philosophy to education? What do philosophical
purposes, skills and attitudes bring to educational
practice? What might they accomplish? My concern in what
follows is not with any particular set of philosophical doctrines,
nor am I inquiring after the educational implications
of this or that philosophical viewpoint. Rather, my
questions pertain to philosophical activity itself. The questions
are thus quite general and they are certainly not
new. But they take on special urgency when viewed in the
perspective of current trends that are likely increasingly
to affect our future circumstances of life and our operative
conceptions of education
DUAL THERAPY TREATMENT OF PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA WITH BLINOTUMOMAB AND A STANDARD CHEMOTHERAPY REGIMEN
Leukemia is the number one cancer affecting children in the nation, with acute lymphoblastic leukemia being the most prevalent classification.1 While new and innovative treatment protocols have greatly increased the success rate of primary cancer patients, those who face relapse receive a much more dismal prognosis. Recent studies have shown that patients who relapse quite frequently have developed drug-resistant clones of the original cancer cells, leading to a need for various secondary treatment options. The drug-resistance is due to clonal mutations that take place within the cancer cell, most often because of an outside pressure or stress within the environment of the cell. In fact, studies show that in many cases the chemotherapy and radiation treatment administered to the leukemia patients provides the added pressures necessary to promote these clonal mutations, leading to treatment-resistant cells and the onset of relapsed leukemia. Various immunotherapies are becoming the front-line secondary treatment option due to their high success rates and innovative techniques. Monoclonal antibodies such as Blinatumomab or Inatuzumab are currently the primary targets of research for acute lymphoblastic leukemia secondary therapy. However, dual therapy treatments of cancers have shown increased rates of event-free survival, overall survival, and progression-free survival, as well as decreased rates of drug resistant cancer cells. Therefore, the goal of this review is to promote the application of dual treatment therapy on relapsed ALL cells for improved outcome, as well as on primary ALL cells for decreased drug resistance
Is philosophy of education a historical mistake? Connecting philosophy and education differently
In this article, I suggest that the question whether the proper place for philosophy of education is in the domain of philosophy or the domain of education cannot be resolved as long as we think of the connection between philosophy and education in terms of the idea of 'philosophy of education'. To substantiate this point, I look into the history of the idea of 'philosophy of education', both as a general idea and with regard to the way in which it became institutionalised in universities in the English-speaking world. I contrast this with the way in which the academic study of education developed in German-speaking countries in order to highlight that 'philosophy of education' is not the only way in which philosophy and education can be connected. Being aware that the connection between philosophy and education can be made differently not only provides a way out of the discussion about the proper identity and location of philosophy of education, but also hints at forms of philosophically informed scholarship that are more firmly based with the academic field of education rather than that they remain a halfway house in between philosophy and education
Bottom-up isotropization in classical-statistical lattice gauge theory
We compute nonequilibrium dynamics for classical-statistical SU(2) pure gauge
theory on a lattice. We consider anisotropic initial conditions with high
occupation numbers in the transverse plane on a characteristic scale ~ Q_s.
This is used to investigate the very early stages of the thermalization process
in the context of heavy-ion collisions. We find Weibel or "primary"
instabilities with growth rates similar to those obtained from previous
treatments employing anisotropic distributions of hard modes (particles) in the
weak coupling limit. We observe "secondary" growth rates for higher-momentum
modes reaching substantially larger values and we analyse them in terms of
resummed loop diagrams beyond the hard-loop approximation. We find that a
coarse grained pressure isotropizes "bottom-up" with a characteristic inverse
rate of gamma^{-1} ~ 1 - 2 fm/c for coarse graining momentum scales of p < 1
GeV choosing an initial energy density for RHIC of epsilon = 30 GeV/fm^3. The
nonequilibrium spatial Wilson loop is found to exhibit an area law and to
become isotropic on a similar time scale.Comment: 22 pages, 12 figures. Phys. Rev. D version, appendix on insensitivity
to volume and cutoff effects adde
Low-energy electronic properties of clean CaRuO: elusive Landau quasiparticles
We have prepared high-quality epitaxial thin films of CaRuO with residual
resistivity ratios up to 55. Shubnikov-de Haas oscillations in the
magnetoresistance and a temperature dependence in the electrical
resistivity only below 1.5 K, whose coefficient is substantially suppressed in
large magnetic fields, establish CaRuO as a Fermi liquid (FL) with
anomalously low coherence scale. Non-Fermi liquid (NFL) dependence is
found between 2 and 25 K. The high sample quality allows access to the
intrinsic electronic properties via THz spectroscopy. For frequencies below 0.6
THz, the conductivity is Drude-like and can be modeled by FL concepts, while
for higher frequencies non-Drude behavior, inconsistent with FL predictions, is
found. This establishes CaRuO as a prime example of optical NFL behavior in
the THz range.Comment: 12 pages, 21 figures including supplemental materia
Role of semicore states in the electronic structure of group-III nitrides: An exact exchange study
The bandstructure of the zinc-blende phase of AlN, GaN, InN is calculated
employing the exact-exchange (EXX) Kohn-Sham density-functional theory and a
pseudopotential plane-wave approach. The cation semicore d electrons are
treated both as valence and as core states. The EXX bandgaps of AlN and GaN
(obtained with the Ga 3d electrons included as core states) are in excellent
agreement with previous EXX results, GW calculations and experiment. Inclusion
of the semicore d electrons as valence states leads to a large reduction in the
EXX bandgaps of GaN and InN. Contrary to common belief, the removal of the
self-interaction, by the EXX approach, does not account for the large
disagreement for the position of the semicore d electrons between the LDA
results and experiment.Comment: 10 pages including 3 figures; related publications can be found at
http://www.fhi-berlin.mpg.de/th/th.htm
Why is a noble metal catalytically active? The role of the O-Ag interaction in the function of silver as an oxidation catalyst
Extensive density-functional theory calculations, and taking into account
temperature and pressure, affords a comprehensive picture of the behavior and
interaction of oxygen and Ag(111), and provides valuable insight into the
function of silver as an oxidation catalyst. The obtained phase-diagram reveals
the most stable species present in a given environment and thus identifies (and
excludes) possibly active oxygen species. In particular, for the conditions of
ethylene epoxidation, a thin oxide-like structure is most stable, suggesting
that such atomic O species are actuating the catalysis, in contrast to hitherto
proposed molecular-like species.Comment: 4 pages including 3 figures, Related publications can be found at
http://www.fhi-berlin.mpg.de/th/paper.htm
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