3,301 research outputs found
Interior regularity criteria for suitable weak solutions of the Navier-Stokes equations
We present new interior regularity criteria for suitable weak solutions of
the 3-D Navier-Stokes equations: a suitable weak solution is regular near an
interior point if either the scaled -norm of the velocity
with , , or the -norm of the
vorticity with , , or the
-norm of the gradient of the vorticity with , , , is sufficiently small near
On admissibility criteria for weak solutions of the Euler equations
We consider solutions to the Cauchy problem for the incompressible Euler
equations satisfying several additional requirements, like the global and local
energy inequalities. Using some techniques introduced in an earlier paper we
show that, for some bounded compactly supported initial data, none of these
admissibility criteria singles out a unique weak solution.
As a byproduct we show bounded initial data for which admissible solutions to
the p-system of isentropic gas dynamics in Eulerian coordinates are not unique
in more than one space dimension.Comment: 33 pages, 1 figure; v2: 35 pages, corrected typos, clarified proof
Instability of the expression of morphological and phenological descriptors to environmental variation in white oat.
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De novo SCN1A mutations in Dravet syndrome and related epileptic encephalopathies are largely of paternal origin
Background: Dravet syndrome is a severe infantile epileptic encephalopathy caused in approximately 80% of cases by mutations in the voltage gated sodium channel subunit gene SCN1A. The majority of these mutations are de novo. The parental origin of de novo mutations varies widely among genetic disorders and the aim of this study was to determine this for Dravet syndrome. Methods: 91 patients with de novo SCN1A mutations and their parents were genotyped for single nucleotide polymorphisms (SNPs) in the region surrounding their mutation. Allele specific polymerase chain reaction (PCR) based on informative SNPs was used to separately amplify and sequence the paternal and maternal alleles to determine in which parental chromosome the mutation arose. Results: The parental origin of SCN1A mutations was established in 44 patients for whom both parents were available and SNPs were informative. The mutations were of paternal origin in 33 cases and of maternal origin in the remaining 11 cases. De novo mutation of SCN1A most commonly, but not exclusively, originates from the paternal chromosome. The average age of parents originating mutations did not differ from that of the general population. Conclusions: The greater frequency of paternally derived mutations in SCN1A is likely to be due to the greater chance of mutational events during the increased number of mitoses which occur during spermatogenesis compared to oogenesis, and the greater susceptibility to mutagenesis of the methylated DNA characteristic of sperm cells.Sarah E. Heron, Ingrid E. Scheffer, Xenia Iona, Sameer M. Zuberi, Rachael Birch, Jacinta M. McMahon, Carla M. Bruce, Samuel F. Berkovic, John C. Mulle
The aetiologies of epilepsy
The identification of the aetiology of a patient's epilepsy is instrumental in the diagnosis, prognostic counselling and management of the epilepsies. Indeed, the aetiology can be important for determining the recurrence risk of single seizures and so for making a diagnosis of epilepsy. Here, we divide the aetiologies into six categories: structural, genetic, infectious, metabolic, immune (all of which are part of the International League Against Epilepsy [ILAE] classification system) and neurodegenerative (which we have considered separately because of its growing importance in epilepsy). These are not mutually exclusive categories and many aetiologies fall into more than one category. Indeed, genetic factors probably play a role, to varying degrees, in the risk of seizures in all people with epilepsy. In each of the categories, we discuss what we regard as the most important aetiologies; importance being determined not only by prevalence but also by clinical significance. The introduction contains information suitable for level 1 competency (entry level), whilst the subsequent sections contain information aimed at level 2 competency (proficiency level) as part of the new ILAE competency-based curriculum. As we move towards precision medicine and targeted therapies, so aetiologies will play an even greater role in the management of epilepsy
A Cognitive Model of an Epistemic Community: Mapping the Dynamics of Shallow Lake Ecosystems
We used fuzzy cognitive mapping (FCM) to develop a generic shallow lake
ecosystem model by augmenting the individual cognitive maps drawn by 8
scientists working in the area of shallow lake ecology. We calculated graph
theoretical indices of the individual cognitive maps and the collective
cognitive map produced by augmentation. The graph theoretical indices revealed
internal cycles showing non-linear dynamics in the shallow lake ecosystem. The
ecological processes were organized democratically without a top-down
hierarchical structure. The steady state condition of the generic model was a
characteristic turbid shallow lake ecosystem since there were no dynamic
environmental changes that could cause shifts between a turbid and a clearwater
state, and the generic model indicated that only a dynamic disturbance regime
could maintain the clearwater state. The model developed herein captured the
empirical behavior of shallow lakes, and contained the basic model of the
Alternative Stable States Theory. In addition, our model expanded the basic
model by quantifying the relative effects of connections and by extending it.
In our expanded model we ran 4 simulations: harvesting submerged plants,
nutrient reduction, fish removal without nutrient reduction, and
biomanipulation. Only biomanipulation, which included fish removal and nutrient
reduction, had the potential to shift the turbid state into clearwater state.
The structure and relationships in the generic model as well as the outcomes of
the management simulations were supported by actual field studies in shallow
lake ecosystems. Thus, fuzzy cognitive mapping methodology enabled us to
understand the complex structure of shallow lake ecosystems as a whole and
obtain a valid generic model based on tacit knowledge of experts in the field.Comment: 24 pages, 5 Figure
Lack of uniqueness for weak solutions of the incompressible porous media equation
In this work we consider weak solutions of the incompressible 2-D porous
media equation. By using the approach of De Lellis-Sz\'ekelyhidi we prove
non-uniqueness for solutions in in space and time.Comment: 23 pages, 2 fugure
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